U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lats1 large tumor suppressor kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308265, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
Lats1provided by RGD
Official Full Name
large tumor suppressor kinase 1provided by RGD
Primary source
RGD:1564085
See related
EnsemblRapid:ENSRNOG00000014916 AllianceGenome:RGD:1564085
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564085
Summary
Predicted to enable several functions, including ATP binding activity; estrogen receptor binding activity; and magnesium ion binding activity. Predicted to be involved in several processes, including mitotic cell cycle phase transition; regulation of cellular protein metabolic process; and regulation of signal transduction. Predicted to act upstream of or within cellular protein localization; inner cell mass cell differentiation; and keratinocyte differentiation. Predicted to be active in spindle pole. Orthologous to human LATS1 (large tumor suppressor kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 139.6), Lung (RPKM 126.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Lats1 in Genome Data Viewer
Location:
1p13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (3980801..4014029)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (2160411..2193640)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (1784078..1817310)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098770 Neighboring gene LDL receptor related protein 11 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 Neighboring gene nucleoporin 43 Neighboring gene small ribosomal subunit protein uS12-like Neighboring gene katanin catalytic subunit A1 Neighboring gene HN1-like pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Decreased expression of LATS1 correlates with astrogliosis after spinal cord injury. Wang Y, et al. Biochem Biophys Res Commun, 2018 Oct 20. PMID 30241940
  2. Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. Iida S, et al. Oncogene, 2004 Jul 8. PMID 15122335
  3. A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis. Nishiyama Y, et al. FEBS Lett, 1999 Oct 8. PMID 10518011
  4. Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. St John MA, et al. Nat Genet, 1999 Feb. PMID 9988269
  5. LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. Yang X, et al. Nat Cell Biol, 2004 Jul. PMID 15220930

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LATS1/YAP1 Axis Controls Bone Regeneration on Distraction Osteogenesis by Activating Wnt/beta-Catenin.
    Title: LATS1/YAP1 Axis Controls Bone Regeneration on Distraction Osteogenesis by Activating Wnt/β-Catenin.
  2. Data indicate that large tumor suppressor kinase 1 (LATS1) might participate in reactive astrogliosis after spinal cord injury.
    Title: Decreased expression of LATS1 correlates with astrogliosis after spinal cord injury.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic sequestering of protein ISO
Inferred from Sequence Orthology
more info
  
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in hormone-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner cell mass cell fate commitment ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner cell mass cellular morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in mammary gland epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of organ growth IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynaptic density assembly EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of postsynaptic density assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic density assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
serine/threonine-protein kinase LATS1
Names
LATS, large tumor suppressor, homolog 1
NP_001128015.2
XP_038966819.1
XP_038966822.1
XP_063144688.1
XP_063144691.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134543.2 → NP_001128015.2  serine/threonine-protein kinase LATS1

    See identical proteins and their annotated locations for NP_001128015.2

    Status: VALIDATED

    Source sequence(s)
    FN804841, JAXUCZ010000001
    UniProtKB/TrEMBL
    F1M2K4
    Related
    ENSRNOP00000020098.6, ENSRNOT00000020098.9
    Conserved Domains (3) summary
    PHA03247
    Location:183 → 590
    PHA03247; large tegument protein UL36; Provisional
    cd05625
    Location:703 → 1084
    STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1
    cl21463
    Location:103 → 143
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    3980801..4014029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110894.1 → XP_038966822.1  serine/threonine-protein kinase LATS1 isoform X2

    Related
    ENSRNOP00000101033.1, ENSRNOT00000123353.1
    Conserved Domains (3) summary
    PHA03247
    Location:66 → 473
    PHA03247; large tegument protein UL36; Provisional
    cd05625
    Location:586 → 967
    STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1
    cl21463
    Location:1 → 26
    UBA_like_SF; UBA domain-like superfamily

  2. XM_063288618.1 → XP_063144688.1  serine/threonine-protein kinase LATS1 isoform X1

    UniProtKB/TrEMBL
    F1M2K4

  3. XM_063288621.1 → XP_063144691.1  serine/threonine-protein kinase LATS1 isoform X3

  4. XM_039110891.2 → XP_038966819.1  serine/threonine-protein kinase LATS1 isoform X1

    UniProtKB/TrEMBL
    F1M2K4
    Conserved Domains (3) summary
    PHA03247
    Location:183 → 590
    PHA03247; large tegument protein UL36; Provisional
    cd05625
    Location:703 → 1084
    STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1
    cl21463
    Location:103 → 143
    UBA_like_SF; UBA domain-like superfamily
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous