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nr5a2 nuclear receptor subfamily 5, group A, member 2 [ Danio rerio (zebrafish) ]

Gene ID: 30749, updated on 2-Nov-2024

Summary

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Official Symbol
nr5a2provided by ZNC
Official Full Name
nuclear receptor subfamily 5, group A, member 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-79
See related
Ensembl:ENSDARG00000100940 AllianceGenome:ZFIN:ZDB-GENE-990415-79
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ftz; sf1; LRH1; ff1a; zFF1; ftzf1; zFF1A; zFF1B
Summary
Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within several processes, including cartilage development; digestive system development; and hepatoblast differentiation. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including digestive system; endocrine system; head; nervous system; and slow muscle cell. Orthologous to human NR5A2 (nuclear receptor subfamily 5 group A member 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See nr5a2 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (22632288..22721093, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (22608571..22696121, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137489015 Neighboring gene adhesion G-protein coupled receptor D2 Neighboring gene uncharacterized LOC137488930 Neighboring gene uncharacterized LOC137488931 Neighboring gene microRNA mir-181b-3 Neighboring gene microRNA 181a-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A zebrafish ftz-F1 (Fushi tarazu factor 1) homologue requires multiple subdomains in the D and E regions for its transcriptional activity. Liu D, et al. J Biol Chem, 2000 Jun 2. PMID 10747875
  2. FTZ-F1alpha is expressed in the developing gonad of frogs. Takase M, et al. Biochim Biophys Acta, 2000 Nov 15. PMID 11072086
  3. Determination of the expression pattern of the dual promoter of zebrafish fushi tarazu factor-1a following microinjections into zebrafish one cell stage embryos. von Hofsten J, et al. Gen Comp Endocrinol, 2005 May 15. PMID 15862566
  4. Transcriptional regulation of the rainbow trout CYP19a gene by FTZ-F1 homologue. Kanda H, et al. J Steroid Biochem Mol Biol, 2006 May. PMID 16621513
  5. Zebrafish ftz-f1a (nuclear receptor 5a2) functions in skeletal muscle organization. Sheela SG, et al. Dev Biol, 2005 Oct 15. PMID 16162335

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nuclear receptor Nr5a2 promotes diverse connective tissue fates in the jaw.
    Title: Nuclear receptor Nr5a2 promotes diverse connective tissue fates in the jaw.
  2. chemical inhibition of Nr5a2 function during hepatopancreas progenitor specification was sufficient to disrupt exocrine pancreas formation and enhance the size of the embryonic liver, suggesting that Nr5a2 regulates hepatic vs. pancreatic progenitor fate choice.
    Title: Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development.
  3. The role of Sox9a in ff1a gene regulation and function was studied using sox9a morpholinos.
    Title: Sox9a regulation of ff1a in zebrafish (Danio rerio) suggests an involvement of ff1a in cartilage development.
  4. ff1a functions in both slow and fast muscle morphogenesis in response to Hedgehog signaling, and this function parallels the activity of another slow muscle gene, prox1
    Title: Zebrafish ftz-f1a (nuclear receptor 5a2) functions in skeletal muscle organization.
  5. The cloning and expression of 4 homologous genes in D. rerio are reported.
    Title: Gene duplication, gene loss and evolution of expression domains in the vertebrate nuclear receptor NR5A (Ftz-F1) family.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within digestive tract development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within exocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hepatoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear receptor subfamily 5 group A member 2
Names
fushi tarazu
steroidogenic factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313729.1 → NP_001300658.1  nuclear receptor subfamily 5 group A member 2

    Status: VALIDATED

    Source sequence(s)
    CR513789
    UniProtKB/TrEMBL
    A0A0R4IW70, A0A8N7XJG3, B3DJL1, Q90YL6
    Related
    ENSDARP00000141532.2, ENSDART00000166794.2
    Conserved Domains (3) summary
    cd07069
    Location:277 → 517
    NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
    cd07167
    Location:46 → 138
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
    pfam14596
    Location:204 → 294
    STAT6_C; STAT6 C-terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    22632288..22721093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009296226.4 → XP_009294501.1  nuclear receptor subfamily 5 group A member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AXL9
    Conserved Domains (3) summary
    cd07069
    Location:267 → 507
    NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
    cd07167
    Location:36 → 128
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
    pfam14596
    Location:194 → 284
    STAT6_C; STAT6 C-terminal

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_131463.1: Suppressed sequence

    Description
    NM_131463.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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