Mex3c mex-3 RNA binding family member C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mex3cprovided by RGD
Official Full Name: mex-3 RNA binding family member Cprovided by RGD
Primary source: RGD:1309023
See related: AllianceGenome:RGD:1309023
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rkhd2
Summary: Predicted to enable RNA binding activity and ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within chondrocyte hypertrophy; energy homeostasis; and regulation of fat cell differentiation. Orthologous to human MEX3C (mex-3 RNA binding family member C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 175.1), Thymus (RPKM 163.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (69442850..69463843)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (67167600..67188595)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (69549937..69571736)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU026787 (e-PCR)
- UniSTS:113937

BE111942 (e-PCR)
- UniSTS:245818

NIB1810 (e-PCR)
- UniSTS:48557

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chondrocyte hypertrophy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within energy homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RNA-binding E3 ubiquitin-protein ligase MEX3C

Names: RNA-binding protein MEX3C; mex-3 homolog C; ring finger and KH domain containing 2

NP_001100847.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107377.1 → NP_001100847.1 RNA-binding E3 ubiquitin-protein ligase MEX3C

See identical proteins and their annotated locations for NP_001100847.1

Status: PROVISIONAL

Source sequence(s)

CH473971

UniProtKB/TrEMBL

A6IY13

Conserved Domains (3) summary

smart00322
Location:131 → 196

KH; K homology RNA-binding domain

cd00105
Location:38 → 99

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam13920
Location:413 → 458

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)