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Camk1d calcium/calmodulin-dependent protein kinase ID [ Rattus norvegicus (Norway rat) ]

Gene ID: 307124, updated on 10-Jul-2024

Summary

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Official Symbol
Camk1dprovided by RGD
Official Full Name
calcium/calmodulin-dependent protein kinase IDprovided by RGD
Primary source
RGD:1560691
See related
EnsemblRapid:ENSRNOG00000017882 AllianceGenome:RGD:1560691
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560691
Summary
Predicted to enable calmodulin binding activity and calmodulin-dependent protein kinase activity. Predicted to be involved in several processes, including positive regulation of CREB transcription factor activity; positive regulation of neutrophil chemotaxis; and regulation of neuron projection development. Predicted to act upstream of or within negative regulation of apoptotic process and positive regulation of apoptotic process. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human CAMK1D (calcium/calmodulin dependent protein kinase ID). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 69.1), Thymus (RPKM 54.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Camk1d in Genome Data Viewer
Location:
17q12.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (77491191..77892018)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (72581899..72982704)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (76532611..76938956)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551026 Neighboring gene uncharacterized LOC102551092 Neighboring gene uncharacterized LOC108348589 Neighboring gene coiled-coil domain containing 3 Neighboring gene uncharacterized LOC108348590

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function. Verploegen S, et al. Blood, 2005 Aug 1. PMID 15840691
  2. Effects of PU.1-induced mouse calcium-calmodulin-dependent kinase I-like kinase (CKLiK) on apoptosis of murine erythroleukemia cells. Yamada T, et al. Exp Cell Res, 2004 Mar 10. PMID 14980499
  3. Identification and characterization of CKLiK, a novel granulocyte Ca(++)/calmodulin-dependent kinase. Verploegen S, et al. Blood, 2000 Nov 1. PMID 11050006
  4. A cascade of Ca(2+)/calmodulin-dependent protein kinases regulates the differentiation and functional activation of murine neutrophils. Gaines P, et al. Exp Hematol, 2008 Jul. PMID 18400360, Free PMC Article
  5. Prominent expression and activity-dependent nuclear translocation of Ca2+/calmodulin-dependent protein kinase Idelta in hippocampal neurons. Sakagami H, et al. Eur J Neurosci, 2005 Dec. PMID 16324104

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of respiratory burst ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of granulocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calcium/calmodulin-dependent protein kinase type 1D
NP_001100835.1
XP_038951705.1
XP_038951706.1
XP_038951707.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107365.1 → NP_001100835.1  calcium/calmodulin-dependent protein kinase type 1D

    See identical proteins and their annotated locations for NP_001100835.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473990
    UniProtKB/TrEMBL
    A0A8I6AUH0, A6JLY7, F1LVR4
    Related
    ENSRNOP00000095984.1, ENSRNOT00000105055.2
    Conserved Domains (1) summary
    cd14168
    Location:12 → 312
    STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    77491191..77892018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095777.2 → XP_038951705.1  calcium/calmodulin-dependent protein kinase type 1D isoform X1

    UniProtKB/TrEMBL
    F1LVR4
    Related
    ENSRNOP00000024099.7, ENSRNOT00000024099.8
    Conserved Domains (1) summary
    cd14168
    Location:12 → 312
    STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta

  2. XM_039095778.2 → XP_038951706.1  calcium/calmodulin-dependent protein kinase type 1D isoform X2

    UniProtKB/TrEMBL
    F1LVR4
    Conserved Domains (1) summary
    cd14168
    Location:12 → 312
    STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta

  3. XM_039095779.2 → XP_038951707.1  calcium/calmodulin-dependent protein kinase type 1D isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1 → 215
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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