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Tenm3 teneurin transmembrane protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306451, updated on 2-Nov-2024

Summary

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Symbol
Tenm3provided by RGD
Full Name
teneurin transmembrane protein 3provided by RGD
Primary source
RGD:1306641
See related
EnsemblRapid:ENSRNOG00000012802 AllianceGenome:RGD:1306641
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Odz3
Summary
Predicted to enable cell adhesion molecule binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; regulation of homophilic cell adhesion; and synaptic membrane adhesion. Predicted to be located in plasma membrane. Predicted to be active in glutamatergic synapse; neuron projection; and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human TENM3 (teneurin transmembrane protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 118.7), Uterus (RPKM 100.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tenm3 in Genome Data Viewer
Location:
16q11
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (47984732..50711352)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (41251909..43978594)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (46422676..46929023)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene mitochondrial import receptor subunit TOM20 homolog pseudogene Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene Neighboring gene large ribosomal subunit protein uL16-like Neighboring gene uncharacterized LOC120097405 Neighboring gene U11 spliceosomal RNA Neighboring gene large ribosomal subunit protein mL48-like Neighboring gene uncharacterized LOC134482499 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134482498 Neighboring gene uncharacterized protein DDB_G0271670-like Neighboring gene uncharacterized LOC102552563 Neighboring gene uncharacterized LOC134482500 Neighboring gene macrophage migration inhibitory factor, pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ten-m3 is required for the development of topography in the ipsilateral retinocollicular pathway. Dharmaratne N, et al. PLoS One, 2012. PMID 23028443, Free PMC Article
  2. Homozygous null mutation in ODZ3 causes microphthalmia in humans. Aldahmesh MA, et al. Genet Med, 2012 Nov. PMID 22766609
  3. Ten_m3 regulates eye-specific patterning in the mammalian visual pathway and is required for binocular vision. Leamey CA, et al. PLoS Biol, 2007 Sep. PMID 17803360, Free PMC Article
  4. Teneurin-3 controls topographic circuit assembly in the hippocampus. Berns DS, et al. Nature, 2018 Feb 15. PMID 29414938, Free PMC Article
  5. Differential gene expression between sensory neocortical areas: potential roles for Ten_m3 and Bcl6 in patterning visual and somatosensory pathways. Leamey CA, et al. Cereb Cortex, 2008 Jan. PMID 17478416

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in camera-type eye morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in regulation of homophilic cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of homophilic cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic membrane adhesion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
teneurin-3
Names
odd Oz/ten-m homolog 3
odz, odd Oz/ten-m homolog 3
odz, odd Oz/ten-m homolog 3-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001169133.2 → NP_001162604.1  teneurin-3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6ABL2, A6JPJ6
    Related
    ENSRNOP00000091422.1, ENSRNOT00000105413.2
    Conserved Domains (9) summary
    COG3209
    Location:1918 → 2429
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1183 → 1222
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:1838 → 1878
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:2333 → 2407
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1154 → 1513
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1630 → 1661
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 307
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2630 → 2707
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:463 → 814
    exchanger_TraA; outer membrane exchange protein TraA

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    47984732..50711352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275416.1 → XP_063131486.1  teneurin-3 isoform X1

  2. XM_039094506.2 → XP_038950434.1  teneurin-3 isoform X1

    UniProtKB/TrEMBL
    A6JPJ6
    Conserved Domains (9) summary
    COG3209
    Location:1925 → 2436
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1190 → 1229
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:1845 → 1885
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:2340 → 2414
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1161 → 1520
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1637 → 1668
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 307
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2637 → 2714
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:463 → 821
    exchanger_TraA; outer membrane exchange protein TraA

  3. XM_039094513.2 → XP_038950441.1  teneurin-3 isoform X5

    UniProtKB/TrEMBL
    A6JPJ6
    Conserved Domains (9) summary
    COG3209
    Location:1918 → 2429
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1190 → 1225
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:1838 → 1878
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:2333 → 2407
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1161 → 1513
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1630 → 1661
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 307
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2630 → 2707
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:463 → 821
    exchanger_TraA; outer membrane exchange protein TraA

  4. XM_039094510.2 → XP_038950438.1  teneurin-3 isoform X2

    UniProtKB/TrEMBL
    A6JPJ6
    Related
    ENSRNOP00000111639.1, ENSRNOT00000140066.1
    Conserved Domains (9) summary
    COG3209
    Location:1924 → 2435
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1189 → 1228
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:1844 → 1884
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:2339 → 2413
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1160 → 1519
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1636 → 1667
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 307
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2636 → 2713
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:463 → 820
    exchanger_TraA; outer membrane exchange protein TraA

  5. XM_039094512.2 → XP_038950440.1  teneurin-3 isoform X4

    UniProtKB/TrEMBL
    A0A8I6ABL2, A6JPJ6
    Conserved Domains (9) summary
    COG3209
    Location:1918 → 2429
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1183 → 1222
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:1838 → 1878
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:2333 → 2407
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1154 → 1513
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1630 → 1661
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 307
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2630 → 2707
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:463 → 814
    exchanger_TraA; outer membrane exchange protein TraA

  6. XM_039094511.2 → XP_038950439.1  teneurin-3 isoform X3

    UniProtKB/TrEMBL
    A6JPJ6
    Conserved Domains (9) summary
    COG3209
    Location:1924 → 2435
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1189 → 1228
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:1844 → 1884
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:2339 → 2413
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1160 → 1519
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1636 → 1667
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 307
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2636 → 2713
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:463 → 806
    exchanger_TraA; outer membrane exchange protein TraA

  7. XM_039094507.2 → XP_038950435.1  teneurin-3 isoform X1

    UniProtKB/TrEMBL
    A6JPJ6
    Conserved Domains (9) summary
    COG3209
    Location:1925 → 2436
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1190 → 1229
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:1845 → 1885
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:2340 → 2414
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1161 → 1520
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1637 → 1668
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 307
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2637 → 2714
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:463 → 821
    exchanger_TraA; outer membrane exchange protein TraA

  8. XM_039094514.2 → XP_038950442.1  teneurin-3 isoform X6

    UniProtKB/TrEMBL
    A6JPJ6
    Related
    ENSRNOP00000109669.1, ENSRNOT00000137496.1
    Conserved Domains (9) summary
    COG3209
    Location:1909 → 2420
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1174 → 1213
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:1829 → 1869
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:2324 → 2398
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1145 → 1504
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1621 → 1652
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 307
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2621 → 2698
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:463 → 791
    exchanger_TraA; outer membrane exchange protein TraA

  9. XM_039094515.2 → XP_038950443.1  teneurin-3 isoform X7

    UniProtKB/TrEMBL
    A0A8I5Y4Y3, A6JPJ6
    Related
    ENSRNOP00000076753.1, ENSRNOT00000094358.2
    Conserved Domains (9) summary
    COG3209
    Location:1902 → 2413
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1174 → 1209
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:1822 → 1862
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:2317 → 2391
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1145 → 1497
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1614 → 1645
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 307
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2614 → 2691
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:463 → 791
    exchanger_TraA; outer membrane exchange protein TraA

  10. XM_039094516.2 → XP_038950444.1  teneurin-3 isoform X8

    UniProtKB/TrEMBL
    A6JPJ6
    Conserved Domains (9) summary
    COG3209
    Location:1832 → 2343
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1097 → 1136
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:1752 → 1792
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:2247 → 2321
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1068 → 1427
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1544 → 1575
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 214
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2544 → 2621
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:370 → 728
    exchanger_TraA; outer membrane exchange protein TraA

  11. XM_063275418.1 → XP_063131488.1  teneurin-3 isoform X9

  12. XM_063275419.1 → XP_063131489.1  teneurin-3 isoform X10

    UniProtKB/TrEMBL
    F1LV44
    Related
    ENSRNOP00000017625.7, ENSRNOT00000017624.8

  13. XM_039094508.2 → XP_038950436.1  teneurin-3 isoform X1

    UniProtKB/TrEMBL
    A6JPJ6
    Conserved Domains (9) summary
    COG3209
    Location:1925 → 2436
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1190 → 1229
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:1845 → 1885
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:2340 → 2414
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1161 → 1520
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1637 → 1668
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 307
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2637 → 2714
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:463 → 821
    exchanger_TraA; outer membrane exchange protein TraA

  14. XM_063275417.1 → XP_063131487.1  teneurin-3 isoform X1

  15. XM_039094509.2 → XP_038950437.1  teneurin-3 isoform X1

    UniProtKB/TrEMBL
    A6JPJ6
    Conserved Domains (9) summary
    COG3209
    Location:1925 → 2436
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1190 → 1229
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:1845 → 1885
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:2340 → 2414
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1161 → 1520
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1637 → 1668
    RHS_repeat; RHS Repeat
    pfam06484
    Location:11 → 307
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2637 → 2714
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:463 → 821
    exchanger_TraA; outer membrane exchange protein TraA

  16. XM_039094517.2 → XP_038950445.1  teneurin-3 isoform X11

    UniProtKB/TrEMBL
    A6JPJ6
    Conserved Domains (9) summary
    COG3209
    Location:1654 → 2165
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:919 → 958
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:1574 → 1614
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:2069 → 2143
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:890 → 1249
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1366 → 1397
    RHS_repeat; RHS Repeat
    pfam06484
    Location:1 → 36
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2366 → 2443
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:192 → 550
    exchanger_TraA; outer membrane exchange protein TraA

  17. XM_063275424.1 → XP_063131494.1  teneurin-3 isoform X11

  18. XM_063275420.1 → XP_063131490.1  teneurin-3 isoform X11

  19. XM_063275421.1 → XP_063131491.1  teneurin-3 isoform X12

  20. XM_063275422.1 → XP_063131492.1  teneurin-3 isoform X13

    Related
    ENSRNOP00000112352.1, ENSRNOT00000168106.1

  21. XM_063275423.1 → XP_063131493.1  teneurin-3 isoform X11

Nucleotide Protein Strain
Heading Accession and Version

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