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Scara5 scavenger receptor class A, member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305974, updated on 2-Nov-2024

Summary

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Official Symbol
Scara5provided by RGD
Official Full Name
scavenger receptor class A, member 5provided by RGD
Primary source
RGD:1306539
See related
EnsemblRapid:ENSRNOG00000014398 AllianceGenome:RGD:1306539
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306539
Summary
Predicted to enable ferritin receptor activity. Predicted to be involved in several processes, including intracellular iron ion homeostasis; iron ion transmembrane transport; and protein homotrimerization. Predicted to act upstream of or within cellular response to heat. Predicted to be located in cell surface and plasma membrane. Orthologous to human SCARA5 (scavenger receptor class A member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 74.3), Heart (RPKM 65.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Scara5 in Genome Data Viewer
Location:
15p12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (44055576..44160593)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (39880017..39985007)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (49069142..49177159)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene nuclear GTPase, germinal center associated Neighboring gene uncharacterized LOC120097185 Neighboring gene uncharacterized LOC108352941 Neighboring gene uncharacterized LOC134482136 Neighboring gene PDZ binding kinase Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of murine SCARA5, a novel class A scavenger receptor that is expressed by populations of epithelial cells. Jiang Y, et al. J Biol Chem, 2006 Apr 28. PMID 16407294
  2. Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Li JY, et al. Dev Cell, 2009 Jan. PMID 19154717, Free PMC Article
  3. Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels. Antoni G, et al. BMC Med Genet, 2011 Aug 2. PMID 21810271, Free PMC Article
  4. Analysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouse lenses. Fujimoto M, et al. J Biol Chem, 2008 Oct 31. PMID 18755693, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ferritin receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to heat ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in iron ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homotrimerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
scavenger receptor class A member 5
Names
scavenger receptor class A, member 5 (putative)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135855.2 → NP_001129327.1  scavenger receptor class A member 5 isoform 2

    See identical proteins and their annotated locations for NP_001129327.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6K6K2
    Conserved Domains (3) summary
    pfam01391
    Location:307 → 374
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:390 → 490
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:395 → 490
    SRCR; Scavenger receptor cysteine-rich domain

  2. NM_001431432.1 → NP_001418361.1  scavenger receptor class A member 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    D3Z926, D4A213

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    44055576..44160593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252204.4 → XP_006252266.1  scavenger receptor class A member 5 isoform X1

    Related
    ENSRNOP00000019487.5, ENSRNOT00000019487.7
    Conserved Domains (3) summary
    pfam01391
    Location:307 → 374
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:391 → 491
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:396 → 491
    SRCR; Scavenger receptor cysteine-rich domain
Nucleotide Protein Strain
Heading Accession and Version

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