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Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305963, updated on 17-Aug-2024

Summary

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Official Symbol
Pinx1provided by RGD
Official Full Name
PIN2/TERF1 interacting, telomerase inhibitor 1provided by RGD
Primary source
RGD:1566025
See related
EnsemblRapid:ENSRNOG00000012012 AllianceGenome:RGD:1566025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566025
Summary
Predicted to enable telomerase RNA binding activity and telomerase inhibitor activity. Predicted to be involved in several processes, including negative regulation of DNA biosynthetic process; positive regulation of protein localization to nucleolus; and protein localization to organelle. Predicted to act upstream of or within telomere maintenance via telomerase. Predicted to be located in several cellular components, including chromosomal region; nuclear lumen; and spindle. Orthologous to human PINX1 (PIN2 (TERF1) interacting telomerase inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 39.5), Spleen (RPKM 34.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pinx1 in Genome Data Viewer
Location:
15p12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (42273805..42333047)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (38097896..38157143)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (47211682..47270343)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene XK related 6 Neighboring gene microRNA 598 Neighboring gene uncharacterized LOC102553493 Neighboring gene uncharacterized LOC134482131 Neighboring gene uncharacterized LOC102549097 Neighboring gene similar to human chromosome 8 open reading frame 74 Neighboring gene SRY-box transcription factor 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of PINX1 expression ameliorates lipopolysaccharide-induced lung injury and alleviates cell senescence during the convalescent phase through affecting the telomerase activity. Li S, et al. Aging (Albany NY), 2021 Mar 26. PMID 33819185, Free PMC Article
  2. Rat homolog of PinX1 is a nucleolar protein involved in the regulation of telomere length. Oh BK, et al. Gene, 2007 Oct 1. PMID 17624691
  3. Association of PINX1 but not TEP1 Polymorphisms with Progression to Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B Virus Infection. Sriprapun M, et al. Asian Pac J Cancer Prev, 2016. PMID 27221889
  4. PinX1 is involved in telomerase recruitment and regulates telomerase function by mediating its localization. Cheung DH, et al. FEBS Lett, 2012 Sep 21. PMID 22749911
  5. PinX1 is recruited to the mitotic chromosome periphery by Nucleolin and facilitates chromosome congression. Li N, et al. Biochem Biophys Res Commun, 2009 Jun 19. PMID 19393617, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of PINX1 expression ameliorates lipopolysaccharide-induced lung injury and alleviates cell senescence during the convalescent phase through affecting the telomerase activity.
    Title: Regulation of PINX1 expression ameliorates lipopolysaccharide-induced lung injury and alleviates cell senescence during the convalescent phase through affecting the telomerase activity.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables telomerase RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables telomerase RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables telomerase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomerase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables telomerase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitotic metaphase chromosome alignment IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of telomere maintenance via telomerase IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to nucleolus IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein localization to nucleolus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to nucleolus IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to nucleolus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance via telomerase IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
PIN2/TERF1-interacting telomerase inhibitor 1
Names
PIN2-interacting protein 1
Pin2-interacting protein X1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083337.2 → NP_001076806.1  PIN2/TERF1-interacting telomerase inhibitor 1

    See identical proteins and their annotated locations for NP_001076806.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    A4L691
    UniProtKB/TrEMBL
    B0BMT3
    Related
    ENSRNOP00000016027.4, ENSRNOT00000016027.7
    Conserved Domains (1) summary
    smart00443
    Location:24 → 69
    G_patch; glycine rich nucleic binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    42273805..42333047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274286.1 → XP_063130356.1  PIN2/TERF1-interacting telomerase inhibitor 1 isoform X4

  2. XM_006252181.5 → XP_006252243.1  PIN2/TERF1-interacting telomerase inhibitor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A1H3
    Related
    ENSRNOP00000085367.1, ENSRNOT00000102140.2
    Conserved Domains (1) summary
    smart00443
    Location:59 → 104
    G_patch; glycine rich nucleic binding domain

  3. XM_039093331.2 → XP_038949259.1  PIN2/TERF1-interacting telomerase inhibitor 1 isoform X3

    Conserved Domains (1) summary
    smart00443
    Location:59 → 104
    G_patch; glycine rich nucleic binding domain

  4. XM_039093329.2 → XP_038949257.1  PIN2/TERF1-interacting telomerase inhibitor 1 isoform X2

    Conserved Domains (1) summary
    smart00443
    Location:59 → 104
    G_patch; glycine rich nucleic binding domain

RNA

  1. XR_010057822.1 RNA Sequence

  2. XR_010057820.1 RNA Sequence

  3. XR_010057821.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4L691.1 GenPept UniProtKB/Swiss-Prot:A4L691

Gene LinkOut

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