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Thtpa thiamine triphosphatase [ Rattus norvegicus (Norway rat) ]

Gene ID: 305889, updated on 2-Nov-2024

Summary

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Official Symbol
Thtpaprovided by RGD
Official Full Name
thiamine triphosphataseprovided by RGD
Primary source
RGD:727917
See related
EnsemblRapid:ENSRNOG00000018105 AllianceGenome:RGD:727917
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable magnesium ion binding activity and thiamine triphosphate phosphatase activity. Predicted to be involved in dephosphorylation and thiamine diphosphate biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human THTPA (thiamine triphosphatase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 166.2), Kidney (RPKM 72.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Thtpa in Genome Data Viewer
Location:
15p13
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32536297..32541537)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28567619..28571580)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33755157..33759117)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene neuroguidin Neighboring gene uncharacterized LOC134482119 Neighboring gene zinc finger homeobox 2 Neighboring gene adaptor related protein complex 1 subunit gamma 2 Neighboring gene junctophilin 4 Neighboring gene dehydrogenase/reductase member 2 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural basis for the catalytic mechanism of mammalian 25-kDa thiamine triphosphatase. Song J, et al. J Biol Chem, 2008 Apr 18. PMID 18276586, Free PMC Article
  2. Molecular characterization of a specific thiamine triphosphatase widely expressed in mammalian tissues. Lakaye B, et al. J Biol Chem, 2002 Apr 19. PMID 11827967
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC94155

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables thiamine triphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiamine triphosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables thiamine triphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables thiamine triphosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in thiamine diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in thiamine diphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in thiamine diphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thiamine diphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in thiamine diphosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in thiamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
thiamine-triphosphatase
Names
thTPase
NP_001007683.1
XP_006252032.1
XP_063130321.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007682.1 → NP_001007683.1  thiamine-triphosphatase

    See identical proteins and their annotated locations for NP_001007683.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081978
    UniProtKB/Swiss-Prot
    Q8CGV7
    UniProtKB/TrEMBL
    A0A0G2JTF6, A6KGY7
    Related
    ENSRNOP00000096778.2, ENSRNOT00000105427.2
    Conserved Domains (1) summary
    cd07758
    Location:6 → 198
    ThTPase; Thiamine Triphosphatase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    32536297..32541537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251970.5 → XP_006252032.1  thiamine-triphosphatase isoform X2

    UniProtKB/TrEMBL
    A0A0G2JTF6, A0A8I6ASR1
    Conserved Domains (1) summary
    cd07758
    Location:6 → 184
    ThTPase; Thiamine Triphosphatase

  2. XM_063274251.1 → XP_063130321.1  thiamine-triphosphatase isoform X1

    UniProtKB/TrEMBL
    A0A8I6AT66
    Related
    ENSRNOP00000106859.1, ENSRNOT00000136381.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CGV7.3 GenPept UniProtKB/Swiss-Prot:Q8CGV7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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