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Ehbp1 EH domain binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305556, updated on 2-Nov-2024

Summary

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Official Symbol
Ehbp1provided by RGD
Official Full Name
EH domain binding protein 1provided by RGD
Primary source
RGD:1310604
See related
EnsemblRapid:ENSRNOG00000008917 AllianceGenome:RGD:1310604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310604
Summary
Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Orthologous to human EHBP1 (EH domain binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 186.9), Brain (RPKM 142.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ehbp1 in Genome Data Viewer
Location:
14q22
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (100294585..100581764, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (96093327..96380502, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (106871426..107160224, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481800 Neighboring gene collagen alpha-1(III) chain-like Neighboring gene orthodenticle homeobox 1 Neighboring gene hornerin-like Neighboring gene ribosome biogenesis protein NSA2 homolog pseudogene Neighboring gene uncharacterized LOC134481801 Neighboring gene uncharacterized LOC134481802 Neighboring gene transmembrane protein 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. EHBP1 Is Critically Involved in the Dendritic Arbor Formation and Is Coupled to Factors Promoting Actin Filament Formation. Ji Y, et al. J Neurosci, 2024 Feb 7. PMID 38129132, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EHBP1 Is Critically Involved in the Dendritic Arbor Formation and Is Coupled to Factors Promoting Actin Filament Formation.
    Title: EHBP1 Is Critically Involved in the Dendritic Arbor Formation and Is Coupled to Factors Promoting Actin Filament Formation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
EH domain-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305130.1 → NP_001292059.1  EH domain-binding protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    F1LVX2
    Related
    ENSRNOP00000012131.8, ENSRNOT00000012131.9
    Conserved Domains (4) summary
    pfam00307
    Location:427 → 523
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1041 → 1181
    DUF3585; Protein of unknown function (DUF3585)
    cl01251
    Location:928 → 1012
    OHCU_decarbox; OHCU decarboxylase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    100294585..100581764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273264.1 → XP_063129334.1  EH domain-binding protein 1 isoform X11

  2. XM_063273263.1 → XP_063129333.1  EH domain-binding protein 1 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZZB4
    Related
    ENSRNOP00000083406.1, ENSRNOT00000096295.2

  3. XM_017599244.3 → XP_017454733.1  EH domain-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    F1LVX2
    Conserved Domains (4) summary
    pfam00307
    Location:427 → 523
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1044 → 1184
    DUF3585; Protein of unknown function (DUF3585)
    cl01251
    Location:928 → 1012
    OHCU_decarbox; OHCU decarboxylase

  4. XM_063273262.1 → XP_063129332.1  EH domain-binding protein 1 isoform X9

  5. XM_063273257.1 → XP_063129327.1  EH domain-binding protein 1 isoform X6

  6. XM_063273258.1 → XP_063129328.1  EH domain-binding protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZKB4

  7. XM_006251565.3 → XP_006251627.1  EH domain-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006251627.1

    UniProtKB/TrEMBL
    F1LVX2
    Conserved Domains (4) summary
    pfam00307
    Location:427 → 523
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1044 → 1184
    DUF3585; Protein of unknown function (DUF3585)
    cl01251
    Location:928 → 1012
    OHCU_decarbox; OHCU decarboxylase

  8. XM_008770445.4 → XP_008768667.1  EH domain-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_008768667.1

    UniProtKB/TrEMBL
    F1LVX2
    Related
    ENSRNOP00000107146.1, ENSRNOT00000157515.1
    Conserved Domains (4) summary
    pfam00307
    Location:427 → 523
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1044 → 1184
    DUF3585; Protein of unknown function (DUF3585)
    cl01251
    Location:928 → 1012
    OHCU_decarbox; OHCU decarboxylase

  9. XM_063273261.1 → XP_063129331.1  EH domain-binding protein 1 isoform X8

  10. XM_063273259.1 → XP_063129329.1  EH domain-binding protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZKB4

  11. XM_063273253.1 → XP_063129323.1  EH domain-binding protein 1 isoform X3

  12. XM_063273255.1 → XP_063129325.1  EH domain-binding protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AC10

  13. XM_063273252.1 → XP_063129322.1  EH domain-binding protein 1 isoform X2

  14. XM_063273251.1 → XP_063129321.1  EH domain-binding protein 1 isoform X1

  15. XM_006251568.3 → XP_006251630.1  EH domain-binding protein 1 isoform X9

    See identical proteins and their annotated locations for XP_006251630.1

    UniProtKB/TrEMBL
    F1LVX2
    Conserved Domains (4) summary
    pfam00307
    Location:351 → 447
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:968 → 1108
    DUF3585; Protein of unknown function (DUF3585)
    cl01251
    Location:852 → 936
    OHCU_decarbox; OHCU decarboxylase

  16. XM_063273260.1 → XP_063129330.1  EH domain-binding protein 1 isoform X8

  17. XM_039092088.2 → XP_038948016.1  EH domain-binding protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZKB4, F1LVX2
    Conserved Domains (4) summary
    COG1196
    Location:833 → 1109
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:980 → 1108
    DUF3585; Protein of unknown function (DUF3585)
    cd21254
    Location:389 → 495
    CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

  18. XM_063273256.1 → XP_063129326.1  EH domain-binding protein 1 isoform X5

  19. XM_006251566.3 → XP_006251628.1  EH domain-binding protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006251628.1

    UniProtKB/TrEMBL
    F1LVX2
    Related
    ENSRNOP00000077506.2, ENSRNOT00000095555.2
    Conserved Domains (4) summary
    pfam00307
    Location:392 → 488
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1009 → 1149
    DUF3585; Protein of unknown function (DUF3585)
    cl01251
    Location:893 → 977
    OHCU_decarbox; OHCU decarboxylase

  20. XM_006251567.3 → XP_006251629.1  EH domain-binding protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006251629.1

    UniProtKB/TrEMBL
    A0A8I6AC10, F1LVX2
    Related
    ENSRNOP00000090221.1, ENSRNOT00000114018.2
    Conserved Domains (4) summary
    pfam00307
    Location:427 → 523
    CH; Calponin homology (CH) domain
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1008 → 1148
    DUF3585; Protein of unknown function (DUF3585)
    cl01251
    Location:892 → 976
    OHCU_decarbox; OHCU decarboxylase

  21. XM_063273265.1 → XP_063129335.1  EH domain-binding protein 1 isoform X12

  22. XM_039092087.2 → XP_038948015.1  EH domain-binding protein 1 isoform X12

    Conserved Domains (3) summary
    COG1196
    Location:399 → 676
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12130
    Location:547 → 675
    DUF3585; Protein of unknown function (DUF3585)
    cl00030
    Location:1 → 26
    CH_SF; calponin homology (CH) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version

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