U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

N4bp2 NEDD4 binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305342, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
N4bp2provided by RGD
Official Full Name
NEDD4 binding protein 2provided by RGD
Primary source
RGD:1565738
See related
EnsemblRapid:ENSRNOG00000027152 AllianceGenome:RGD:1565738
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565738
Summary
Predicted to enable ATP binding activity; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; and DNA endonuclease activity. Predicted to be involved in DNA metabolic process. Predicted to be located in cytosol. Orthologous to human N4BP2 (NEDD4 binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 102.6), Liver (RPKM 83.6) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See N4bp2 in Genome Data Viewer
Location:
14p11
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (42696415..42819535, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (42342690..42479861, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (43963353..44092844, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene cholinergic receptor nicotinic alpha 9 subunit Neighboring gene HAUS augmin-like complex, subunit 8, pseudogene 3 Neighboring gene ras homolog family member H Neighboring gene U6 spliceosomal RNA Neighboring gene PDS5 cohesin associated factor A Neighboring gene ribosomal protein L14 like 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. Murillas R, et al. J Biol Chem, 2002 Jan 25. PMID 11717310
  2. Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination. Watanabe N, et al. J Biol Chem, 2003 Jul 11. PMID 12730195
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
NEDD4-binding protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    42696415..42819535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092735.2 → XP_038948663.1  NEDD4-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A4H4, A0A8I6GHF3
    Related
    ENSRNOP00000088789.2, ENSRNOT00000099507.2
    Conserved Domains (4) summary
    smart00463
    Location:1677 → 1759
    SMR; Small MutS-related domain
    cd14365
    Location:47 → 87
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:1610 → 1671
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:455 → 581
    AAA_33; AAA domain

  2. XM_017599466.3 → XP_017454955.1  NEDD4-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A4H4
    Conserved Domains (3) summary
    smart00463
    Location:1597 → 1679
    SMR; Small MutS-related domain
    pfam08590
    Location:1530 → 1591
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:375 → 501
    AAA_33; AAA domain

  3. XM_039092734.2 → XP_038948662.1  NEDD4-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A4H4, A0A8I6GHF3
    Conserved Domains (4) summary
    smart00463
    Location:1677 → 1759
    SMR; Small MutS-related domain
    cd14365
    Location:47 → 87
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:1610 → 1671
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:455 → 581
    AAA_33; AAA domain

  4. XM_017599459.3 → XP_017454948.1  NEDD4-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A4H4, A0A8I6GHF3
    Related
    ENSRNOP00000085430.2, ENSRNOT00000112523.2
    Conserved Domains (4) summary
    smart00463
    Location:1677 → 1759
    SMR; Small MutS-related domain
    cd14365
    Location:47 → 87
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:1610 → 1671
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:455 → 581
    AAA_33; AAA domain

  5. XM_039092736.2 → XP_038948664.1  NEDD4-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A4H4, A0A8I6GHF3
    Conserved Domains (4) summary
    smart00463
    Location:1677 → 1759
    SMR; Small MutS-related domain
    cd14365
    Location:47 → 87
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:1610 → 1671
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:455 → 581
    AAA_33; AAA domain

  6. XM_017599463.3 → XP_017454952.1  NEDD4-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A4H4
    Conserved Domains (3) summary
    smart00463
    Location:1597 → 1679
    SMR; Small MutS-related domain
    pfam08590
    Location:1530 → 1591
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:375 → 501
    AAA_33; AAA domain

  7. XM_017599465.3 → XP_017454954.1  NEDD4-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A4H4
    Conserved Domains (3) summary
    smart00463
    Location:1597 → 1679
    SMR; Small MutS-related domain
    pfam08590
    Location:1530 → 1591
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:375 → 501
    AAA_33; AAA domain

  8. XM_063273824.1 → XP_063129894.1  NEDD4-binding protein 2 isoform X2

  9. XM_063273823.1 → XP_063129893.1  NEDD4-binding protein 2 isoform X2

  10. XM_039092740.2 → XP_038948668.1  NEDD4-binding protein 2 isoform X3

    Conserved Domains (2) summary
    smart00463
    Location:1149 → 1231
    SMR; Small MutS-related domain
    pfam08590
    Location:1082 → 1143
    DUF1771; Domain of unknown function (DUF1771)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools