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opn1mw4 opsin 1 (cone pigments), medium-wave-sensitive, 4 [ Danio rerio (zebrafish) ]

Gene ID: 30504, updated on 19-Oct-2024

Summary

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Official Symbol
opn1mw4provided by ZNC
Official Full Name
opsin 1 (cone pigments), medium-wave-sensitive, 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-990604-43
See related
Ensembl:ENSDARG00000000638 AllianceGenome:ZFIN:ZDB-GENE-990604-43
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
RH2-4; rh2.4; zfgr2; grops2; wu:fk64b02
Summary
Predicted to enable G protein-coupled photoreceptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to light stimulus; and phototransduction. Predicted to act upstream of or within protein-chromophore linkage; signal transduction; and visual perception. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in photoreceptor outer segment. Predicted to be integral component of plasma membrane. Is expressed in several structures, including endocrine system; gut; heart; integument; and visual system. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See opn1mw4 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (41200505..41202554)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (41202969..41205018)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene opsin 1 (cone pigments), medium-wave-sensitive, 2 Neighboring gene opsin 1 (cone pigments), medium-wave-sensitive, 3 Neighboring gene synaptoporin b Neighboring gene uncharacterized LOC137495887

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Predicting peak spectral sensitivities of vertebrate cone visual pigments using atomistic molecular simulations. Patel JS, et al. PLoS Comput Biol, 2018 Jan. PMID 29364888, Free PMC Article
  2. Reconstitution of ancestral green visual pigments of zebrafish and molecular mechanism of their spectral differentiation. Chinen A, et al. Mol Biol Evol, 2005 Apr. PMID 15647516
  3. Spatially differentiated expression of quadruplicated green-sensitive RH2 opsin genes in zebrafish is determined by proximal regulatory regions and gene order to the locus control region. Tsujimura T, et al. BMC Genet, 2015 Nov 4. PMID 26537431, Free PMC Article
  4. Regeneration of cone photoreceptors when cell ablation is primarily restricted to a particular cone subtype. Fraser B, et al. PLoS One, 2013. PMID 23383182, Free PMC Article
  5. Thyroid hormone receptor beta mutations alter photoreceptor development and function in Danio rerio (zebrafish). Deveau C, et al. PLoS Genet, 2020 Jun. PMID 32569302, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled photoreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables photoreceptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to light stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phototransduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phototransduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in photoreceptor outer segment IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
green-sensitive opsin-4
Names
green cone photoreceptor pigment 4
green-sensitive opsin 2
opsin RH2-4
opsin-1, medium-wave-sensitive 4
rhodopsin-like-2.4 cone opsin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131254.1 → NP_571329.1  green-sensitive opsin-4

    See identical proteins and their annotated locations for NP_571329.1

    Status: PROVISIONAL

    Source sequence(s)
    AF109370
    UniProtKB/Swiss-Prot
    Q8AYM6, Q9W6A6
    Related
    ENSDARP00000000979.6, ENSDART00000000678.7
    Conserved Domains (3) summary
    pfam00001
    Location:55 → 306
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10413
    Location:2 → 37
    Rhodopsin_N; Amino terminal of the G-protein receptor rhodopsin
    cl21561
    Location:126 → 315
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    41200505..41202554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W6A6.2 GenPept UniProtKB/Swiss-Prot:Q9W6A6

Gene LinkOut

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