rxrga retinoid x receptor, gamma a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rxrgaprovided by ZNC
Official Full Name: retinoid x receptor, gamma aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-36
See related: Ensembl:ENSDARG00000005593 AllianceGenome:ZFIN:ZDB-GENE-980526-36
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: RXR; rxra; rxrg; NR2B1
Summary: Enables nuclear receptor activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within intracellular receptor signaling pathway and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including mesoderm; neural rod; pharyngeal arch; retina; and tail bud. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human RXRG (retinoid X receptor gamma). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: suggests misassembly
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (20725684..20776841)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (21067712..21118926)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity.
Title: Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity.
The RA receptors RXR gamma and RAR alpha-b are expressed in patterns consistent with mediating the effects of RA on photoreceptors.
Title: Plasticity of photoreceptor-generating retinal progenitors revealed by prolonged retinoic acid exposure.

Submit: New GeneRIF Correction

General gene information

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Markers

rxra (e-PCR), detects polymorphism
- UniSTS:238284

RXRA (e-PCR)
- UniSTS:205307

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotation more info
enables retinoic acid-responsive element binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular receptor signaling pathway	IDA Inferred from Direct Assay more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info
involved_in retinoic acid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: retinoic acid receptor RXR-gamma-A

Names: NR2B3; nr2b3a; nuclear receptor subfamily 2 group B member 3-A; retinoic acid receptor RXR-alpha; retinoid X receptor alpha; retinoid X receptor gamma-A; retinoid receptor-alpha; retinoid x receptor, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131217.4 → NP_571292.3 retinoic acid receptor RXR-gamma-A

Status: VALIDATED

Source sequence(s)

BC059576, CABZ01020455, CABZ01063427, CABZ01063428, CU855759, EH435141, FO681336

UniProtKB/Swiss-Prot

Q6PBU9, Q90416

UniProtKB/TrEMBL

A0A8N1TSS1

Related

ENSDART00000021168.9

Conserved Domains (3) summary

cd06943
Location:211 → 419

NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily

cd06956
Location:115 → 191

NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers

pfam11825
Location:40 → 111

Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1