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Lmtk2 lemur tyrosine kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304286, updated on 10-Oct-2024

Summary

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Official Symbol
Lmtk2provided by RGD
Official Full Name
lemur tyrosine kinase 2provided by RGD
Primary source
RGD:1598332
See related
EnsemblRapid:ENSRNOG00000025155 AllianceGenome:RGD:1598332
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable myosin VI binding activity; protein phosphatase inhibitor activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including early endosome to late endosome transport; protein phosphorylation; and transferrin transport. Located in growth cone and neuronal cell body. Orthologous to human LMTK2 (lemur tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 215.9), Kidney (RPKM 206.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lmtk2 in Genome Data Viewer
Location:
12p11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (15540428..15622392, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (10426772..10508750, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (12409876..12546111, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554669 Neighboring gene brain protein I3 Neighboring gene tectonin beta-propeller repeat containing 1 Neighboring gene basic helix-loop-helix family, member a15 Neighboring gene elongation factor 1-gamma-like Neighboring gene oncomodulin Neighboring gene CCZ1 homolog, vacuolar protein trafficking and biogenesis associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Peptide microarray analysis of substrate specificity of the transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic fibrosis transmembrane conductance regulator and phosphorylase. Wang H, et al. Mol Cell Proteomics, 2006 Nov. PMID 16887929
  2. A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. Wang H, et al. J Biol Chem, 2002 Dec 20. PMID 12393858
  3. Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment. Chibalina MV, et al. J Cell Sci, 2007 Dec 15. PMID 18029400, Free PMC Article
  4. Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase. Kesavapany S, et al. J Neurosci, 2003 Jun 15. PMID 12832520, Free PMC Article
  5. BREK/LMTK2 is a myosin VI-binding protein involved in endosomal membrane trafficking. Inoue T, et al. Genes Cells, 2008 May. PMID 18429820

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin VI binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in transferrin transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase LMTK2
NP_001414165.1
XP_038945281.1
XP_038945282.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427236.1 → NP_001414165.1  serine/threonine-protein kinase LMTK2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    D3ZBH5
    Related
    ENSRNOP00000050872.4, ENSRNOT00000046381.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    15540428..15622392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089354.2 → XP_038945282.1  serine/threonine-protein kinase LMTK2 isoform X2

    UniProtKB/TrEMBL
    A6K1I1
    Related
    ENSRNOP00000083057.1, ENSRNOT00000092637.3
    Conserved Domains (2) summary
    PHA03247
    Location:1002 → 1381
    PHA03247; large tegument protein UL36; Provisional
    cd05086
    Location:137 → 407
    PTKc_Aatyk2; Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2

  2. XM_039089353.2 → XP_038945281.1  serine/threonine-protein kinase LMTK2 isoform X1

    UniProtKB/TrEMBL
    A6K1I1
    Conserved Domains (2) summary
    PHA03247
    Location:1003 → 1382
    PHA03247; large tegument protein UL36; Provisional
    cd05086
    Location:138 → 408
    PTKc_Aatyk2; Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001137641.1: Suppressed sequence

    Description
    NM_001137641.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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