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Krt16 keratin 16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303530, updated on 17-Aug-2024

Summary

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Official Symbol
Krt16provided by RGD
Official Full Name
keratin 16provided by RGD
Primary source
RGD:1590901
See related
EnsemblRapid:ENSRNOG00000003899 AllianceGenome:RGD:1590901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ka16; Krt14; Krt14l
Summary
Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including hair cycle; keratinocyte migration; and skin development. Predicted to act upstream of or within intermediate filament cytoskeleton organization. Predicted to be located in intermediate filament. Biomarker of esophagus squamous cell carcinoma. Human ortholog(s) of this gene implicated in ectodermal dysplasia; focal nonepidermolytic palmoplantar keratoderma 1; and pachyonychia congenita. Orthologous to human KRT16 (keratin 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 21.7), Kidney (RPKM 6.7) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Krt16 in Genome Data Viewer
Location:
10q31
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (85669276..85672211, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85168357..85171816, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88149210..88152167, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene keratin 14 Neighboring gene type I keratin KA11 Neighboring gene keratin 17 Neighboring gene keratin 42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Forced expression of keratin 16 alters the adhesion, differentiation, and migration of mouse skin keratinocytes. Wawersik M, et al. Mol Biol Cell, 2000 Oct. PMID 11029038, Free PMC Article
  2. Aberrant heterodimerization of keratin 16 with keratin 6A in HaCaT keratinocytes results in diminished cellular migration. Trost A, et al. Mech Ageing Dev, 2010 May. PMID 20403371
  3. Identification of cytokeratin subspecies altered in rat experimental esophageal tumors by subtractive cloning. Wang DY, et al. Cancer Lett, 1996 Nov 12. PMID 8950218
  4. Keratin 16 regulates innate immunity in response to epidermal barrier breach. Lessard JC, et al. Proc Natl Acad Sci U S A, 2013 Nov 26. PMID 24218583, Free PMC Article
  5. Keratin 16 expression defines a subset of epithelial cells during skin morphogenesis and the hair cycle. Bernot KM, et al. J Invest Dermatol, 2002 Nov. PMID 12445204

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables structural constituent of cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of skin barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in hair cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intermediate filament cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratinization ISO
Inferred from Sequence Orthology
more info
  
involved_in keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in keratinocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in morphogenesis of an epithelium ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cornified envelope ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament ISO
Inferred from Sequence Orthology
more info
  
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
keratin, type I cytoskeletal 16
Names
keratin 14
keratin 14-like
keratin 16, type I
type I keratin KA16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008752.2 → NP_001008752.1  keratin, type I cytoskeletal 16

    See identical proteins and their annotated locations for NP_001008752.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    Q6IFU9
    Related
    ENSRNOP00000019477.3, ENSRNOT00000019477.5
    Conserved Domains (2) summary
    pfam00038
    Location:105 → 413
    Filament; Intermediate filament protein
    cl14876
    Location:237 → 318
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    85669276..85672211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247309.5 → XP_006247371.1  keratin, type I cytoskeletal 16 isoform X1

    Conserved Domains (2) summary
    pfam00038
    Location:105 → 413
    Filament; Intermediate filament protein
    cl14876
    Location:237 → 318
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
Nucleotide Protein Strain
Heading Accession and Version

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