Kat7 lysine acetyltransferase 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kat7provided by RGD
Official Full Name: lysine acetyltransferase 7provided by RGD
Primary source: RGD:727966
See related: EnsemblRapid:ENSRNOG00000022664 AllianceGenome:RGD:727966
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Myst2
Summary: Predicted to enable several functions, including DNA replication origin binding activity; histone acetyltransferase activity; and transcription coregulator activity. Predicted to be involved in several processes, including histone acetylation; positive regulation of erythrocyte differentiation; and regulation of cellular macromolecule biosynthetic process. Predicted to be located in cytosol; nucleoplasm; and site of DNA damage. Predicted to be part of histone H3-K14 acetyltransferase complex. Orthologous to human KAT7 (lysine acetyltransferase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 234.0), Thymus (RPKM 172.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (80718335..80752387, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (80221519..80255590, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (83095067..83128342, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alteration of histone acetyltransferase CREB-binding protein acetylation of high mobility group box protein(HMGB)-1 and -2 and truncated forms lacking C-terminal tails is regarded as a mechanism by which the acidic tail modulates some properties of HMGBs.
Title: In vitro acetylation of HMGB-1 and -2 proteins by CBP: the role of the acidic tail.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA replication origin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K14 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K14 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K23 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K4 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H4 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K12 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K12 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
NOT enables histone H4K16 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
NOT enables histone H4K16 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H4K5 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K5 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H4K8 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K8 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication-dependent chromatin disassembly	ISO Inferred from Sequence Orthology more info
involved_in DNA replication-dependent chromatin disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in internal peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info
involved_in internal peptidyl-lysine acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in natural killer cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription, elongation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription, elongation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of hematopoietic stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hematopoietic stem cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated DNA replication initiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated DNA replication initiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of nucleotide-excision repair	ISO Inferred from Sequence Orthology more info
involved_in regulation of nucleotide-excision repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to actinomycin D	ISO Inferred from Sequence Orthology more info
involved_in response to anisomycin	ISO Inferred from Sequence Orthology more info
involved_in response to dithiothreitol	ISO Inferred from Sequence Orthology more info
involved_in response to hydroxyurea	ISO Inferred from Sequence Orthology more info
involved_in response to sorbitol	ISO Inferred from Sequence Orthology more info
involved_in stress-activated protein kinase signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone H3-K14 acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone H3-K14 acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of histone H3-K14 acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of histone acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in nucleolus	ISO Inferred from Sequence Orthology more info
NOT located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in site of DNA damage	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: histone acetyltransferase KAT7

Names: K (lysine) acetyltransferase 7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST histone acetyltransferase 2; MYST protein 2; MYST-2; histone acetyltransferase MYST2; histone acetyltransferase binding to ORC1

NP_001402032.1

EC 2.3.1.48

NP_851595.1

EC 2.3.1.48

XP_038941995.1

EC 2.3.1.48

XP_038941996.1

EC 2.3.1.48

XP_038941997.1

EC 2.3.1.48

XP_038941998.1

EC 2.3.1.48

XP_063125180.1

EC 2.3.1.48

XP_063125181.1

EC 2.3.1.48

XP_063125182.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415103.1 → NP_001402032.1 histone acetyltransferase KAT7 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6AGI2, A6HI92, A7BJV7

Related

ENSRNOP00000092089.2, ENSRNOT00000104687.2
NM_181081.4 → NP_851595.1 histone acetyltransferase KAT7 isoform 1

See identical proteins and their annotated locations for NP_851595.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q80YN5, Q810T5

UniProtKB/TrEMBL

A7BJV7

Related

ENSRNOP00000090504.1, ENSRNOT00000109616.2

Conserved Domains (3) summary

pfam01530
Location:185 → 211

zf-C2HC; Zinc finger, C2HC type

pfam01853
Location:394 → 572

MOZ_SAS; MOZ/SAS family

cl17182
Location:330 → 608

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

80718335..80752387 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269112.1 → XP_063125182.1 histone acetyltransferase KAT7 isoform X6

UniProtKB/TrEMBL

A7BJV7
XM_039086068.2 → XP_038941996.1 histone acetyltransferase KAT7 isoform X2

UniProtKB/TrEMBL

A0A8I6GLG6, A6HI91, A7BJV7

Related

ENSRNOP00000096120.1, ENSRNOT00000116805.2

Conserved Domains (4) summary

PLN00104
Location:294 → 579

PLN00104; MYST -like histone acetyltransferase; Provisional

pfam05109
Location:27 → 197

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd16378
Location:209 → 262

CcmH_N; N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins

pfam01530
Location:184 → 212

zf-C2HC; Zinc finger, C2HC type
XM_063269110.1 → XP_063125180.1 histone acetyltransferase KAT7 isoform X4

UniProtKB/TrEMBL

A7BJV7
XM_063269111.1 → XP_063125181.1 histone acetyltransferase KAT7 isoform X5

UniProtKB/TrEMBL

A7BJV7
XM_039086067.2 → XP_038941995.1 histone acetyltransferase KAT7 isoform X1

UniProtKB/TrEMBL

A7BJV7

Conserved Domains (4) summary

PLN00104
Location:295 → 580

PLN00104; MYST -like histone acetyltransferase; Provisional

pfam05109
Location:28 → 198

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd16378
Location:210 → 263

CcmH_N; N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins

pfam01530
Location:185 → 213

zf-C2HC; Zinc finger, C2HC type
XM_039086069.2 → XP_038941997.1 histone acetyltransferase KAT7 isoform X3

UniProtKB/TrEMBL

A7BJV7

Conserved Domains (3) summary

PLN00104
Location:325 → 543

PLN00104; MYST -like histone acetyltransferase; Provisional

pfam05109
Location:28 → 198

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01530
Location:185 → 213

zf-C2HC; Zinc finger, C2HC type
XM_039086070.2 → XP_038941998.1 histone acetyltransferase KAT7 isoform X7

UniProtKB/TrEMBL

A6HI94

Conserved Domains (2) summary

PLN00104
Location:168 → 453

PLN00104; MYST -like histone acetyltransferase; Provisional

pfam01530
Location:28 → 56

zf-C2HC; Zinc finger, C2HC type