Mmd monocyte to macrophage differentiation-associated [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mmdprovided by RGD
Full Name: monocyte to macrophage differentiation-associatedprovided by RGD
Primary source: RGD:1592079
See related: EnsemblRapid:ENSRNOG00000002436 AllianceGenome:RGD:1592079
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Maf
Summary: Predicted to enable protein kinase activity. Predicted to be involved in positive regulation of neuron differentiation; positive regulation of protein kinase activity; and regulation of protein localization. Predicted to be located in Golgi apparatus. Orthologous to human MMD (monocyte to macrophage differentiation associated). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 251.8), Kidney (RPKM 127.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (75570366..75598610)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (75073278..75101528)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (77687964..77783737)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D10Chm108 (e-PCR)
- UniSTS:518019

D10Chm113 (e-PCR)
- UniSTS:518291

D10Chm112 (e-PCR)
- UniSTS:518039

D10Chm102 (e-PCR)
- UniSTS:518079

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables pore-forming activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: monocyte to macrophage differentiation factor

Names: macrophage/microglia activation-associated factor; monocyte to macrophage differentiation protein; progestin and adipoQ receptor family member 11; progestin and adipoQ receptor family member XI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007673.1 → NP_001007674.1 monocyte to macrophage differentiation factor

See identical proteins and their annotated locations for NP_001007674.1

Status: PROVISIONAL

Source sequence(s)

BC081965

UniProtKB/Swiss-Prot

Q719N3

UniProtKB/TrEMBL

A0A0H2UHA9

Related

ENSRNOP00000075635.1, ENSRNOT00000087765.3

Conserved Domains (1) summary

TIGR01065
Location:27 → 227

hlyIII; channel protein, hemolysin III family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

75570366..75598610

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086052.2 → XP_038941980.1 monocyte to macrophage differentiation factor isoform X1

UniProtKB/TrEMBL

A0A0H2UHA9

Conserved Domains (1) summary

cl03831
Location:27 → 202

HlyIII; Haemolysin-III related