Npsr1 neuropeptide S receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Npsr1provided by RGD
Official Full Name: neuropeptide S receptor 1provided by RGD
Primary source: RGD:1564154
See related: EnsemblRapid:ENSRNOG00000015863 AllianceGenome:RGD:1564154
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564154
Summary: Predicted to enable neuropeptide receptor activity. Involved in several processes, including negative regulation of defecation; positive regulation of ERK1 and ERK2 cascade; and righting reflex. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Biomarker of morphine dependence. Human ortholog(s) of this gene implicated in asthma; inflammatory bowel disease; newborn respiratory distress syndrome; and rheumatoid arthritis. Orthologous to human NPSR1 (neuropeptide S receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 2.4), Testes (RPKM 0.7) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (30882830..31107425)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (22606946..22831558)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (25246174..25483582)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Electroacupuncture suppresses the pain and pain-related anxiety of chronic inflammation in rats by increasing the expression of the NPS/NPSR system in the ACC.
Title: Electroacupuncture suppresses the pain and pain-related anxiety of chronic inflammation in rats by increasing the expression of the NPS/NPSR system in the ACC.
(1) NPS efficiently prevents development of and reverses the posttraumatic stress symptomatology caused by exposure to stress; (2) the mechanisms of action involve both the NPS receptor and NPY-Y1R; and (3) NPS may affect the NPY-Y1R, indicating a possible cross talk between the NPYergic system and NPS. Treatment with NPS may be a novel approach for the treatment of the deleterious consequences of stress exposure.
Title: Neuropeptide S in the basolateral amygdala mediates an adaptive behavioral stress response in a rat model of posttraumatic stress disorder by increasing the expression of BDNF and the neuropeptide YY1 receptor.
NPSR expression decreased after single-dose and chronic chlorpromazine administration in the hypothalamus, as well as after chronic olanzapine and chlorpromazine administration in the striatum and hippocampus.
Title: Neuroleptics Affect Neuropeptide S and NPSR mRNA Levels in the Rat Brain.
This study demonistrated that neuropeptide S receptor and Melanin-concentrating hormone colization in neuron in the lateral hypothalamus (LH) and zona incerta (ZI), but MCHR1 mRNA is widely expressed throughout the brain.
Title: Identification of neuropeptide receptors expressed by melanin-concentrating hormone neurons.
These results demonstrated that morphine dependence induction led to changes in NPSR mRNA expression.
Title: Morphine dependence is associated with changes in neuropeptide S receptor expression and function in rat brain.
The distribution of NPSR protein provides further insight into the organization of the NPS system and may guide future studies of the role of the NPSR in the brain.
Title: Immunohistochemical localization of the neuropeptide S receptor in the rat central nervous system.
Nicotine treatment up-regulated neuropeptide s (NPS) and its receptor (NPS-R) in hypothalamus and brainstem.
Title: Nicotine treatment regulates neuropeptide S system expression in the rat brain.
Neuropeptide S receptor messenger ribonucleic acid (mRNA) expression is increased in different brain regions of postdependent alcoholic rats.
Title: Neuropeptide S receptor gene expression in alcohol withdrawal and protracted abstinence in postdependent rats.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables vasopressin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of defecation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in righting reflex	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: neuropeptide S receptor

Names: G-protein coupled receptor 154

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.