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Gpr22 G protein-coupled receptor 22 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298944, updated on 2-Nov-2024

Summary

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Official Symbol
Gpr22provided by RGD
Official Full Name
G protein-coupled receptor 22provided by RGD
Primary source
RGD:1310848
See related
EnsemblRapid:ENSRNOG00000008423 AllianceGenome:RGD:1310848
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cellular response to hormone stimulus. Located in plasma membrane. Orthologous to human GPR22 (G protein-coupled receptor 22). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 263.0), Brain (RPKM 155.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpr22 in Genome Data Viewer
Location:
6q16
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (54037998..54044994, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (48309619..48317864, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (51012421..51021253, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479362 Neighboring gene dihydrouridine synthase 4-like Neighboring gene component of oligomeric golgi complex 5 Neighboring gene large ribosomal subunit protein eL20-like Neighboring gene HMG-box transcription factor 1 Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of orphan receptors GPR22 and GPR162 in streptozotocin-induced diabetic rats. Ruiz-Hernández A, et al. J Recept Signal Transduct Res, 2015 Feb. PMID 24937127
  2. Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction. Chang CC, et al. BMC Cardiovasc Disord, 2024 May 30. PMID 38816768, Free PMC Article
  3. Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. Adams JW, et al. Am J Physiol Heart Circ Physiol, 2008 Aug. PMID 18539757
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction.
    Title: Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction.
  2. orphan receptors GPR22 and GPR162 are expressed in a different way in heart, kidney, brain and aorta of diabetic and non-diabetic rats. We conclude that orphan receptors could be involved in the development of diabetes complications.
    Title: Expression of orphan receptors GPR22 and GPR162 in streptozotocin-induced diabetic rats.
  3. Demonstrate GRR22 expression in rat heart.
    Title: Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 22
Names
probable G-protein coupled receptor 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106722.1 → NP_001100192.1  G-protein coupled receptor 22

    See identical proteins and their annotated locations for NP_001100192.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473947
    UniProtKB/Swiss-Prot
    D4A3U0
    UniProtKB/TrEMBL
    A0A5H1ZRU0
    Related
    ENSRNOP00000011659.5, ENSRNOT00000011659.8
    Conserved Domains (1) summary
    cd00637
    Location:81 → 406
    7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    54037998..54044994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111962.2 → XP_038967890.1  G-protein coupled receptor 22 isoform X1

    UniProtKB/Swiss-Prot
    D4A3U0
    UniProtKB/TrEMBL
    A0A5H1ZRU0
    Conserved Domains (1) summary
    cd00637
    Location:81 → 406
    7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4A3U0.2 GenPept UniProtKB/Swiss-Prot:D4A3U0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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