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Csf3r colony stimulating factor 3 receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 298518, updated on 2-Nov-2024

Summary

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Official Symbol
Csf3rprovided by RGD
Official Full Name
colony stimulating factor 3 receptorprovided by RGD
Primary source
RGD:1309114
See related
EnsemblRapid:ENSRNOG00000008759 AllianceGenome:RGD:1309114
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cytokine receptor activity and granulocyte colony-stimulating factor binding activity. Involved in amelogenesis. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in hematologic cancer (multiple); hereditary neutrophilia; and severe congenital neutropenia (multiple). Orthologous to human CSF3R (colony stimulating factor 3 receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 32.8), Lung (RPKM 24.6) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Csf3r in Genome Data Viewer
Location:
5q36
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (143583126..143604382)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (138298605..138318224)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (144031353..144051966)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene chaperonin containing Tcp1, subunit 7 (eta), pseudogene 2 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta, pseudogene 5 Neighboring gene mitochondrial ribosomal protein S15 Neighboring gene organic solute carrier partner 1 Neighboring gene ribosomal protein S14, pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of granulocyte colony-stimulating factor 3 receptor in the spinal dorsal horn following spinal nerve ligation-induced neuropathic pain. Zhang E, et al. Mol Med Rep, 2017 Aug. PMID 28656207, Free PMC Article
  2. Mutations in the granulocyte colony-stimulating factor receptor gene in patients with severe congenital neutropenia. Dong F, et al. Leukemia, 1997 Jan. PMID 9001427
  3. Abnormalities of primitive myeloid progenitor cells expressing granulocyte colony-stimulating factor receptor in patients with severe congenital neutropenia. Nakamura K, et al. Blood, 2000 Dec 15. PMID 11110716
  4. Expression and functional analysis of granulocyte colony-stimulating factor receptors on CD34++ cells in patients with myelodysplastic syndrome (MDS) and MDS-acute myeloid leukaemia. Sultana TA, et al. Br J Haematol, 2003 Apr. PMID 12670333
  5. Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs. Makam M, et al. Proc Natl Acad Sci U S A, 2009 Apr 7. PMID 19293384, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the expression of GCSFR in neurons following peripheral nerve injury may be involved in the induction and maintenance of neuropathic pain through the STAT3 and TRPV1 signaling pathway.
    Title: Expression of granulocyte colony-stimulating factor 3 receptor in the spinal dorsal horn following spinal nerve ligation-induced neuropathic pain.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables granulocyte colony-stimulating factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in amelogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immunoglobulin mediated immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
granulocyte colony-stimulating factor receptor
Names
colony stimulating factor 3 receptor (granulocyte)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106685.1 → NP_001100155.1  granulocyte colony-stimulating factor receptor precursor

    See identical proteins and their annotated locations for NP_001100155.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473968
    UniProtKB/TrEMBL
    A6IS82
    Conserved Domains (4) summary
    smart00060
    Location:532 → 609
    FN3; Fibronectin type 3 domain
    cd00063
    Location:433 → 521
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:24 → 111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:123 → 221
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    143583126..143604382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109618.2 → XP_038965546.1  granulocyte colony-stimulating factor receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I6B3M3
    Conserved Domains (4) summary
    smart00060
    Location:571 → 648
    FN3; Fibronectin type 3 domain
    cd00063
    Location:472 → 560
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:24 → 111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:123 → 221
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_039109621.2 → XP_038965549.1  granulocyte colony-stimulating factor receptor isoform X2

    Conserved Domains (4) summary
    smart00060
    Location:571 → 648
    FN3; Fibronectin type 3 domain
    cd00063
    Location:472 → 560
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:24 → 111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:123 → 221
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. XM_039109625.2 → XP_038965553.1  granulocyte colony-stimulating factor receptor isoform X7

    Conserved Domains (2) summary
    smart00060
    Location:438 → 515
    FN3; Fibronectin type 3 domain
    cd00063
    Location:339 → 427
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  4. XM_039109619.2 → XP_038965547.1  granulocyte colony-stimulating factor receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I6B3M3
    Conserved Domains (4) summary
    smart00060
    Location:571 → 648
    FN3; Fibronectin type 3 domain
    cd00063
    Location:472 → 560
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:24 → 111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:123 → 221
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  5. XM_039109617.2 → XP_038965545.1  granulocyte colony-stimulating factor receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I6B3M3
    Conserved Domains (4) summary
    smart00060
    Location:571 → 648
    FN3; Fibronectin type 3 domain
    cd00063
    Location:472 → 560
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:24 → 111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:123 → 221
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  6. XM_017593289.3 → XP_017448778.1  granulocyte colony-stimulating factor receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I6B3M3
    Related
    ENSRNOP00000096023.1, ENSRNOT00000102077.2
    Conserved Domains (4) summary
    smart00060
    Location:571 → 648
    FN3; Fibronectin type 3 domain
    cd00063
    Location:472 → 560
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:24 → 111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:123 → 221
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  7. XM_039109622.2 → XP_038965550.1  granulocyte colony-stimulating factor receptor isoform X3

    Conserved Domains (4) summary
    smart00060
    Location:560 → 637
    FN3; Fibronectin type 3 domain
    cd00063
    Location:461 → 549
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:24 → 111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:123 → 221
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  8. XM_039109623.2 → XP_038965551.1  granulocyte colony-stimulating factor receptor isoform X4

    UniProtKB/TrEMBL
    D4A3R0
    Related
    ENSRNOP00000011694.6, ENSRNOT00000011694.8
    Conserved Domains (4) summary
    smart00060
    Location:543 → 620
    FN3; Fibronectin type 3 domain
    cd00063
    Location:444 → 532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:24 → 111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:123 → 221
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  9. XM_063287439.1 → XP_063143509.1  granulocyte colony-stimulating factor receptor isoform X6

  10. XM_063287437.1 → XP_063143507.1  granulocyte colony-stimulating factor receptor isoform X5

    UniProtKB/TrEMBL
    A6IS82

  11. XM_008764007.4 → XP_008762229.1  granulocyte colony-stimulating factor receptor isoform X5

    See identical proteins and their annotated locations for XP_008762229.1

    UniProtKB/TrEMBL
    A6IS82
    Conserved Domains (4) summary
    smart00060
    Location:532 → 609
    FN3; Fibronectin type 3 domain
    cd00063
    Location:433 → 521
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:24 → 111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:123 → 221
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  12. XM_063287438.1 → XP_063143508.1  granulocyte colony-stimulating factor receptor isoform X5

    UniProtKB/TrEMBL
    A6IS82

  13. XM_039109620.2 → XP_038965548.1  granulocyte colony-stimulating factor receptor isoform X1

    UniProtKB/TrEMBL
    A0A8I6B3M3
    Conserved Domains (4) summary
    smart00060
    Location:571 → 648
    FN3; Fibronectin type 3 domain
    cd00063
    Location:472 → 560
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:24 → 111
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:123 → 221
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  14. XM_039109626.2 → XP_038965554.1  granulocyte colony-stimulating factor receptor isoform X8

    Conserved Domains (2) summary
    smart00060
    Location:393 → 470
    FN3; Fibronectin type 3 domain
    cd00063
    Location:294 → 382
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  15. XM_039109627.2 → XP_038965555.1  granulocyte colony-stimulating factor receptor isoform X9

    Conserved Domains (2) summary
    smart00060
    Location:252 → 329
    FN3; Fibronectin type 3 domain
    cd00063
    Location:153 → 241
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Nucleotide Protein Strain
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