Hspb7 heat shock protein family, member 7 (cardiovascular) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hspb7provided by MGI
Official Full Name: heat shock protein family, member 7 (cardiovascular)provided by MGI
Primary source: MGI:MGI:1352494
See related: Ensembl:ENSMUSG00000006221 AllianceGenome:MGI:1352494
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 27kDa; cvHsp; Hsp25-2
Summary: Enables filamin binding activity. Predicted to be involved in heart development. Located in actin cytoskeleton. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human HSPB7 (heat shock protein family B (small) member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in heart adult (RPKM 366.5) and stomach adult (RPKM 18.0) See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 74.08 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (141148090..141152621)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (141420779..141425310)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors found that deleting HSPB7 resulted in uncontrolled elongation of actin filaments and the formation of atypical actin filament bundles in cardiomyocytes.
Title: HSPB7 is indispensable for heart development by modulating actin filament assembly.
our findings characterize HSPB7 as an intercalated disc protein and suggest it has an essential role in maintaining intercalated disc integrity and conduction function in the adult heart.
Title: HSPB7 prevents cardiac conduction system defect through maintaining intercalated disc integrity.
these data indicate that MEF2 and AP-1 confer antagonistic regulation of Hspb7 gene expression in skeletal muscle, with implications for autophagy and muscle atrophy.
Title: Regulation of Hspb7 by MEF2 and AP-1: implications for Hspb7 in muscle atrophy.
this paper shows that skeletal-muscle-specific ablation of the HspB7 causes postnatal death owing to a respiration defect, with progressive myopathy phenotypes in the diaphragm
Title: HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles.
HSPB7 is a potential early biomarker after MI and serves as an independent risk factor of ACS in patients with acute chest pain.
Title: Association of plasma concentration of small heat shock protein B7 with acute coronary syndrome.
These results imply that HspB2 and HspB7 might be up-regulated by ethanol during the short-term differentiation of neural stem cells.
Title: Ethanol-induced small heat shock protein genes in the differentiation of mouse embryonic neural stem cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables filamin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in heart development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Cajal body	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	IPI Inferred from Physical Interaction more info	PubMed
located_in aggresome	IEA Inferred from Electronic Annotation more info
located_in aggresome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: heat shock protein beta-7

Names: cardiovascular heat shock protein; heat shock 27kDa protein family, member 7 (cardiovascular); heat shock protein 25 kDa 2 (cardiovascular); protein p19/6.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013868.4 → NP_038896.2 heat shock protein beta-7

See identical proteins and their annotated locations for NP_038896.2

Status: PROVISIONAL

Source sequence(s)

AL670285

Consensus CDS

CCDS18873.1

UniProtKB/Swiss-Prot

P35385, Q5FW72, Q8CDI0, Q9QUS2

Related

ENSMUSP00000099544.5, ENSMUST00000102486.5

Conserved Domains (1) summary

cd06479
Location:72 → 152

ACD_HspB7_like; Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB7, also known as cardiovascular small heat shock protein (cvHsp), and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect ...