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Minpp1 multiple inositol-polyphosphate phosphatase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29688, updated on 14-Nov-2024

Summary

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Official Symbol
Minpp1provided by RGD
Official Full Name
multiple inositol-polyphosphate phosphatase 1provided by RGD
Primary source
RGD:3089
See related
EnsemblRapid:ENSRNOG00000011287 AllianceGenome:RGD:3089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity and inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity. Predicted to be active in endoplasmic reticulum lumen; extracellular space; and plasma membrane. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma and pontocerebellar hypoplasia type 16. Orthologous to human MINPP1 (multiple inositol-polyphosphate phosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 247.8), Kidney (RPKM 218.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Minpp1 in Genome Data Viewer
Location:
1q52
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (239766809..239793023)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (230354483..230379730)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (251045352..251071045)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene nuclear transport factor 2, pseudogene 1 Neighboring gene cytokine induced apoptosis inhibitor 1, pseudogene 1 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC134485221 Neighboring gene U2 spliceosomal RNA Neighboring gene 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Neighboring gene uncharacterized LOC134485222

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase. Craxton A, et al. Biochem J, 1997 Nov 15. PMID 9359836, Free PMC Article
  2. Hepatic Ins(1,3,4,5)P4 3-phosphatase is compartmentalized inside endoplasmic reticulum. Ali N, et al. J Biol Chem, 1993 Mar 25. PMID 8384201
  3. Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas. Gimm O, et al. J Clin Endocrinol Metab, 2001 Apr. PMID 11297621
  4. Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt. Cho J, et al. Proc Natl Acad Sci U S A, 2008 Apr 22. PMID 18413611, Free PMC Article
  5. The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification. Caffrey JJ, et al. FEBS Lett, 1999 Jan 8. PMID 9923613

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-phytase activity IEA
Inferred from Electronic Annotation
more info
  
enables 4-phytase activity IEA
Inferred from Electronic Annotation
more info
  
enables acid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bisphosphoglycerate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables bisphosphoglycerate 3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol bisphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol bisphosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables inositol pentakisphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol phosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol trisphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol trisphosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol-hexakisphosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol-hexakisphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol-hexakisphosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
NOT involved_in bone mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular monoatomic cation homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of intracellular monoatomic cation homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of intracellular monoatomic cation homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT involved_in ossification ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol-mediated signaling NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum lumen ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
multiple inositol polyphosphate phosphatase 1
Names
2,3-BPG phosphatase
2,3-bisphosphoglycerate 3-phosphatase
inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase
ins(1,3,4,5)P(4) 3-phosphatase
multiple inositol polyphosphate histidine phosphatase 1
NP_062136.1
XP_063143914.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019263.1 → NP_062136.1  multiple inositol polyphosphate phosphatase 1 precursor

    See identical proteins and their annotated locations for NP_062136.1

    Status: VALIDATED

    Source sequence(s)
    AF012714, CO388212, CV120065
    UniProtKB/Swiss-Prot
    O35217
    UniProtKB/TrEMBL
    A6I107, G3V7H2
    Related
    ENSRNOP00000015017.5, ENSRNOT00000015017.8
    Conserved Domains (1) summary
    cd07061
    Location:82 → 429
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    239766809..239793023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287844.1 → XP_063143914.1  multiple inositol polyphosphate phosphatase 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35217.3 GenPept UniProtKB/Swiss-Prot:O35217

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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