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Lcmt2 leucine carboxyl methyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296098, updated on 2-Nov-2024

Summary

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Official Symbol
Lcmt2provided by RGD
Official Full Name
leucine carboxyl methyltransferase 2provided by RGD
Primary source
RGD:1305829
See related
AllianceGenome:RGD:1305829
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable tRNA methyltransferase activity. Predicted to be involved in tRNA methylation and wybutosine biosynthetic process. Orthologous to human LCMT2 (leucine carboxyl methyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See Lcmt2 in Genome Data Viewer
Location:
3q35
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (128553707..128555831, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (108099960..108102084, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (113089646..113091770, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transglutaminase 5 Neighboring gene transglutaminase 7 Neighboring gene N6-Methyl-AMP deaminase Neighboring gene zinc finger and SCAN domain containing 29, pseudogene 1 Neighboring gene tubulin gamma complex component 4 Neighboring gene tumor protein p53 binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables tRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in wybutosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tRNA wybutosine-synthesizing protein 4
Names
tRNA wybutosine-synthesizing protein 4 homolog
tRNA yW-synthesizing protein 4 homolog
tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase
tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase
NP_001011956.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011956.1 → NP_001011956.1  tRNA wybutosine-synthesizing protein 4

    See identical proteins and their annotated locations for NP_001011956.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083783
    UniProtKB/Swiss-Prot
    Q5XIA3
    Conserved Domains (2) summary
    pfam04072
    Location:26 → 207
    LCM; Leucine carboxyl methyltransferase
    pfam13415
    Location:494 → 542
    Kelch_3; Galactose oxidase, central domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    128553707..128555831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIA3.1 GenPept UniProtKB/Swiss-Prot:Q5XIA3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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