Htr2b 5-hydroxytryptamine receptor 2B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Htr2bprovided by RGD
Official Full Name: 5-hydroxytryptamine receptor 2Bprovided by RGD
Primary source: RGD:61801
See related: EnsemblRapid:ENSRNOG00000017625 AllianceGenome:RGD:61801
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 5-HT2B; 5-HT-2B; 5-HT-2F
Summary: Enables serotonin binding activity. Involved in several processes, including cellular response to serotonin; hepatic stellate cell activation; and inositol phosphate metabolic process. Located in dendrite; neuronal cell body; and plasma membrane. Used to study heart valve disease. Biomarker of brain infarction and congestive heart failure. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatohepatitis and steatotic liver disease. Orthologous to human HTR2B (5-hydroxytryptamine receptor 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 22.8), Thymus (RPKM 22.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q35

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (94184442..94206851, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (86735793..86756638, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (93112781..93130135, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome.
Title: Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome.
Htr2b Promotes M1 Microglia Polarization and Neuroinflammation after Spinal Cord Injury via Inhibition of Neuregulin-1/ErbB Signaling.
Title: Htr2b Promotes M1 Microglia Polarization and Neuroinflammation after Spinal Cord Injury via Inhibition of Neuregulin-1/ErbB Signaling.
5-HT2A/B receptor expression in the phrenic motor nucleus in a rat model of ALS (SOD1(G93A)).
Title: 5-HT2A/B receptor expression in the phrenic motor nucleus in a rat model of ALS (SOD1(G93A)).
Cross-talk inhibition occurs between 5-HT2B and 5-HT7 receptors in phrenic motor facilitation via NADPH oxidase and PKA pathway.
Title: Cross-talk inhibition between 5-HT(2B) and 5-HT(7) receptors in phrenic motor facilitation via NADPH oxidase and PKA.
5-HT stimulates DNA synthesis and proliferation in primary cultures of adult rat hepatocytes by acting via autocrine secretion of TGF-alpha induced by the serotonin 5-HT2B receptor/Gq/PLC/Ca2+ pathway.
Title: Serotonin 5-HT2B Receptor-Stimulated DNA Synthesis and Proliferation Are Mediated by Autocrine Secretion of Transforming Growth Factor-α in Primary Cultures of Adult Rat Hepatocytes.
pBOO induced up-regulation of the 5-HT(2A) and 5-HT(2B) receptors in the detrusor muscle and subserosal layers of the bladder, and such up-regulation may be related to the enhanced bladder contractile response to 5-HT.
Title: Increased expression of 5-HT(2A) and 5-HT(2B) receptors in detrusor muscle after partial bladder outlet obstruction in rats.
Inhibition of apoptosis via modulation of MAPKs/HSPs is essential for 5-HT2BR blockade mediated cardioprotective effect.
Title: 5-HT2B receptor blockade attenuates β-adrenergic receptor-stimulated myocardial remodeling in rats via inhibiting apoptosis: role of MAPKs and HSPs.
5-HT(2B) receptors play a pronociceptive role in peripheral as well as spinal sites in the rat formalin test.
Title: Role of peripheral and spinal 5-HT2B receptors in formalin-induced nociception.
A relationship exists between serotonin, immunocytes, and neuropathic pain during which a critical role of 5-HT(2B) receptors develops in blood-derived macrophages.
Title: Antinociceptive effect of peripheral serotonin 5-HT2B receptor activation on neuropathic pain.
The opposing effects of serotonin, mediated by distinct 5-HT receptors, could explain why drugs targeting serotonin function can cause either diabetes or hypoglycemia in humans.
Title: A novel mechanism for regulating hepatic glycogen synthesis involving serotonin and cyclin-dependent kinase-5.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled serotonin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables G-protein alpha-subunit binding	IEA Inferred from Electronic Annotation more info
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables G-protein alpha-subunit binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables Gq/11-coupled serotonin receptor activity	IEA Inferred from Electronic Annotation more info
enables Gq/11-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serotonin binding	IDA Inferred from Direct Assay more info	PubMed
enables serotonin binding	IEA Inferred from Electronic Annotation more info
enables serotonin binding	ISO Inferred from Sequence Orthology more info
enables serotonin binding	ISS Inferred from Sequence or Structural Similarity more info
enables serotonin receptor activity	IEA Inferred from Electronic Annotation more info
enables serotonin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in G protein-coupled receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled serotonin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cGMP-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cGMP-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac muscle hypertrophy	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle hypertrophy	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to amine stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to serotonin	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to temperature stimulus	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in heart morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in heart morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in heart morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in hepatic stellate cell activation	IEP Inferred from Expression Pattern more info	PubMed
involved_in inositol phosphate metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in intestine smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in intestine smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in intestine smooth muscle contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural crest cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural crest cell migration	IEA Inferred from Electronic Annotation more info
involved_in neural crest cell migration	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating serotonin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of behavior	IEA Inferred from Electronic Annotation more info
involved_in regulation of behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in vasoconstriction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of G protein-coupled serotonin receptor complex	IEA Inferred from Electronic Annotation more info
part_of G protein-coupled serotonin receptor complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 2B

Names: 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; serotonin receptor 2B; stomach fundus serotonin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017250.2 → NP_058946.2 5-hydroxytryptamine receptor 2B

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

P30994, Q9QW44

UniProtKB/TrEMBL

A6JWG0, G3V8A0

Related

ENSRNOP00000023829.3, ENSRNOT00000023829.6

Conserved Domains (2) summary

cd14964
Location:55 → 81

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:54 → 397

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

94184442..94206851 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039083116.2 → XP_038939044.1 5-hydroxytryptamine receptor 2B isoform X2

Conserved Domains (2) summary

cd14964
Location:55 → 81

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:54 → 183

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_063266817.1 → XP_063122887.1 5-hydroxytryptamine receptor 2B isoform X1

UniProtKB/TrEMBL

A6JWG0, G3V8A0