Cybrd1 cytochrome b reductase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cybrd1provided by RGD
Official Full Name: cytochrome b reductase 1provided by RGD
Primary source: RGD:1305740
See related: EnsemblRapid:ENSRNOG00000009620 AllianceGenome:RGD:1305740
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dcytb
Summary: Predicted to enable identical protein binding activity; transmembrane ascorbate ferrireductase activity; and transmembrane monodehydroascorbate reductase activity. Predicted to be involved in ascorbate homeostasis and cellular iron ion homeostasis. Predicted to act upstream of or within response to iron ion. Predicted to be located in apical plasma membrane and brush border membrane. Predicted to be integral component of membrane. Predicted to be active in lysosomal membrane. Orthologous to human CYBRD1 (cytochrome b reductase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 141.4), Spleen (RPKM 79.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (76342231..76369846)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (55934874..55962132)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (57718496..57745749)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that expression of Cybrd1 in intestinal mucosa can be regulated by dietary factors; here, expression of Cybrd1 in mucosa of duodenum is up-regulated by prebiotic supplement, inulin, in iron-deficiency anemia.
Title: Effects of prebiotic supplementation on the expression of proteins regulating iron absorption in anaemic growing rats.
There is an increase in hippocampal expression of duodenal Cybrd1 following kainic acid-induced excitotoxicity.
Title: Expression and localization of duodenal cytochrome b in the rat hippocampus after kainate-induced excitotoxicity.
Whole-genome profiling reveals that increasing dietary protein from 5 to 40% increases duodenal transcript expression of divalent metal transporter 1 (DMT1) 3.2-fold, duodenal cytochrome b (Dcytb) 1.8-fold, and transferrin receptor (TfR) 1.8-fold.
Title: Increasing dietary protein acutely augments intestinal iron transporter expression and significantly increases iron absorption in rats.
Results suggest that the presence of duodenal cytochrome b (Dcytb) in airway epithelial cells and its regulation by iron may contribute to pulmonary cytoprotection [Dcytb].
Title: Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on metal ions	ISO Inferred from Sequence Orthology more info
enables transmembrane ascorbate ferrireductase activity	ISO Inferred from Sequence Orthology more info
enables transmembrane ascorbate ferrireductase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane monodehydroascorbate reductase activity	ISO Inferred from Sequence Orthology more info
enables transmembrane monodehydroascorbate reductase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ascorbate homeostasis	ISO Inferred from Sequence Orthology more info
involved_in ascorbate homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level iron ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to iron ion	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: plasma membrane ascorbate-dependent reductase CYBRD1

Names: duodenal cytochrome b

NP_001011954.1

EC 7.2.1.3

XP_063139345.1

EC 7.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011954.1 → NP_001011954.1 plasma membrane ascorbate-dependent reductase CYBRD1

See identical proteins and their annotated locations for NP_001011954.1

Status: PROVISIONAL

Source sequence(s)

BC085768

UniProtKB/Swiss-Prot

Q5RKJ2

UniProtKB/TrEMBL

A6HM42

Related

ENSRNOP00000012942.4, ENSRNOT00000012942.8

Conserved Domains (1) summary

cl23723
Location:36 → 188

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...