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Hif1a hypoxia inducible factor 1 subunit alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 29560, updated on 2-Nov-2024

Summary

Official Symbol
Hif1aprovided by RGD
Official Full Name
hypoxia inducible factor 1 subunit alphaprovided by RGD
Primary source
RGD:61928
See related
EnsemblRapid:ENSRNOG00000008292 AllianceGenome:RGD:61928
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MOP1; HIF1-alpha
Summary
Enables sequence-specific DNA binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to decreased oxygen levels; positive regulation of angiogenesis; and regulation of gene expression. Located in nucleus. Used to study acute kidney failure; cerebrovascular disease (multiple); diabetic retinopathy; and hepatocellular carcinoma. Biomarker of several diseases, including artery disease (multiple); bladder neck obstruction; bronchopulmonary dysplasia; ischemia (multiple); and kidney failure (multiple). Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 288.5), Kidney (RPKM 268.7) and 9 other tissues See more
Orthologs
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Genomic context

See Hif1a in Genome Data Viewer
Location:
6q24
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (98357788..98405068)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (92624059..92669262)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (96810868..96856303)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 30B Neighboring gene protein kinase C, eta Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene uncharacterized LOC120103553 Neighboring gene transmembrane protein 183A, pseudogene 2 Neighboring gene uncharacterized LOC134479220 Neighboring gene small nuclear RNA activating complex, polypeptide 1 Neighboring gene synaptotagmin 16

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription repressor activity ISO
Inferred from Sequence Orthology
more info
 
enables E-box binding IEA
Inferred from Electronic Annotation
more info
 
enables E-box binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp90 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables p53 binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-containing complex binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transcription regulator activator activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription regulator activator activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in B-1 B cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within B-1 B cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in TOR signaling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in acute-phase response IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in axonal transport of mitochondrion IEA
Inferred from Electronic Annotation
more info
 
involved_in axonal transport of mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in axonal transport of mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within blood vessel development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in bone mineralization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within camera-type eye morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac ventricle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cardiac ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cartilage development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to anoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to carbon monoxide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to cobalt ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to cyanide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to electrical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to estrogen stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to light stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to lipid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to nitrite IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to wortmannin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cerebral cortex development ISO
Inferred from Sequence Orthology
more info
 
involved_in chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in collagen metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in collagen metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in connective tissue replacement involved in inflammatory response wound healing IEA
Inferred from Electronic Annotation
more info
 
involved_in connective tissue replacement involved in inflammatory response wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in digestive tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within digestive tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in dopaminergic neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within dopaminergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in elastin metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in elastin metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic placenta development ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell differentiation involved in mammary gland alveolus development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within epithelial cell differentiation involved in mammary gland alveolus development ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glandular epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in glandular epithelial cell maturation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within glandular epithelial cell maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in heart looping IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within heart looping ISO
Inferred from Sequence Orthology
more info
 
involved_in hemoglobin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hemoglobin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hypoxia-inducible factor-1alpha signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hypoxia-inducible factor-1alpha signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in intestinal epithelial cell maturation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intestinal epithelial cell maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intracellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular oxygen homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intracellular oxygen homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular oxygen homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in iris morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within iris morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in iron import into the mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lactate metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lactate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lactation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lactation ISO
Inferred from Sequence Orthology
more info
 
involved_in maternal process involved in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in mesenchymal cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of mesenchymal cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in muscle cell cellular homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within muscle cell cellular homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of growth IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mesenchymal cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of mesenchymal cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of miRNA transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of thymocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of thymocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neural crest cell migration IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural crest cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in neural fold elevation formation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural fold elevation formation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell size IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of chemokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hormone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of hormone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of stress granule assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of aerobic respiration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of aerobic respiration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glycolytic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein neddylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein neddylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein neddylation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of thymocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transforming growth factor beta2 production IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transforming growth factor beta2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in response to X-ray IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to alkaloid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to anesthetic IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to auditory stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to cobalt ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to fungicide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to glucose IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to iron ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to iron ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to muscle activity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to muscle activity ISO
Inferred from Sequence Orthology
more info
 
involved_in response to purine-containing compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to reactive oxygen species IEA
Inferred from Electronic Annotation
more info
 
involved_in response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
involved_in response to reactive oxygen species ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to salt stress IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in retina vasculature development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within retina vasculature development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in tissue remodeling IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in vascular endothelial growth factor production IEA
Inferred from Electronic Annotation
more info
 
involved_in vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vasculature development ISO
Inferred from Sequence Orthology
more info
 
involved_in visual learning IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within visual learning ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in euchromatin IEA
Inferred from Electronic Annotation
more info
 
located_in euchromatin ISO
Inferred from Sequence Orthology
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hypoxia-inducible factor 1-alpha
Names
HIF1 alpha
hypoxia inducible factor 1 alpha subunit
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024359.2NP_077335.2  hypoxia-inducible factor 1-alpha

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    O35800, Q9WTU9
    UniProtKB/TrEMBL
    A6HC66, D4A8P8
    Related
    ENSRNOP00000112230.1, ENSRNOT00000139912.1
    Conserved Domains (6) summary
    smart00091
    Location:94149
    PAS; PAS domain
    PLN03113
    Location:640788
    PLN03113; DNA ligase 1; Provisional
    pfam08447
    Location:255340
    PAS_3; PAS fold
    cd19727
    Location:1484
    bHLH-PAS_HIF1a_PASD8; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in hypoxia-inducible factor 1-alpha (HIF1a) and similar proteins
    pfam08778
    Location:790825
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam11413
    Location:554580
    HIF-1; Hypoxia-inducible factor-1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    98357788..98405068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240196.5XP_006240258.1  hypoxia-inducible factor 1-alpha isoform X1

    UniProtKB/Swiss-Prot
    O35800, Q9WTU9
    Related
    ENSRNOP00000042230.5, ENSRNOT00000049725.5
    Conserved Domains (6) summary
    smart00091
    Location:94149
    PAS; PAS domain
    cd00083
    Location:1669
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:240339
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:255340
    PAS_3; PAS fold
    pfam08778
    Location:791827
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam11413
    Location:556580
    HIF-1; Hypoxia-inducible factor-1
  2. XM_006240197.5XP_006240259.1  hypoxia-inducible factor 1-alpha isoform X2

    UniProtKB/Swiss-Prot
    O35800, Q9WTU9
    Conserved Domains (6) summary
    smart00091
    Location:93148
    PAS; PAS domain
    cd00083
    Location:1568
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:239338
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:254339
    PAS_3; PAS fold
    pfam08778
    Location:790826
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam11413
    Location:555579
    HIF-1; Hypoxia-inducible factor-1
  3. XM_006240198.5XP_006240260.1  hypoxia-inducible factor 1-alpha isoform X3

    UniProtKB/Swiss-Prot
    O35800, Q9WTU9
    Conserved Domains (6) summary
    smart00091
    Location:93148
    PAS; PAS domain
    cd00083
    Location:1568
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:239338
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:254339
    PAS_3; PAS fold
    pfam08778
    Location:788824
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam11413
    Location:555579
    HIF-1; Hypoxia-inducible factor-1