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S100a5 S100 calcium binding protein A5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295211, updated on 2-Nov-2024

Summary

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Official Symbol
S100a5provided by RGD
Official Full Name
S100 calcium binding protein A5provided by RGD
Primary source
RGD:1308996
See related
EnsemblRapid:ENSRNOG00000011748 AllianceGenome:RGD:1308996
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium-dependent protein binding activity; metal ion binding activity; and protein homodimerization activity. Predicted to be located in neuronal cell body. Predicted to be active in nucleus. Orthologous to human S100A5 (S100 calcium binding protein A5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 24.5), Brain (RPKM 12.3) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See S100a5 in Genome Data Viewer
Location:
2q34
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (178392922..178397128)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (176095332..176099546)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189999669..190005877)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A3 Neighboring gene S100 calcium binding protein A2 Neighboring gene S100 calcium-binding protein A4 Neighboring gene S100 calcium binding protein A6 Neighboring gene S100 calcium binding protein A7A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Solution structure and dynamics of S100A5 in the apo and Ca2+-bound states. Bertini I, et al. J Biol Inorg Chem, 2009 Sep. PMID 19536568
  2. Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily. Schäfer BW, et al. J Biol Chem, 2000 Sep 29. PMID 10882717
  3. Loss of Bardet-Biedl syndrome protein-8 (BBS8) perturbs olfactory function, protein localization, and axon targeting. Tadenev AL, et al. Proc Natl Acad Sci U S A, 2011 Jun 21. PMID 21646512, Free PMC Article
  4. S100A13 and S100A6 exhibit distinct translocation pathways in endothelial cells. Hsieh HL, et al. J Cell Sci, 2002 Aug 1. PMID 12118070
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
  
enables copper ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein S100-A5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106438.1 → NP_001099908.1  protein S100-A5

    See identical proteins and their annotated locations for NP_001099908.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473976
    UniProtKB/Swiss-Prot
    P63083
    UniProtKB/TrEMBL
    A6J6P8
    Related
    ENSRNOP00000015712.4, ENSRNOT00000015712.8
    Conserved Domains (1) summary
    cd00213
    Location:3 → 88
    S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    178392922..178397128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232601.5 → XP_006232663.1  protein S100-A5 isoform X1

    See identical proteins and their annotated locations for XP_006232663.1

    UniProtKB/Swiss-Prot
    P63083
    UniProtKB/TrEMBL
    A6J6P8
    Conserved Domains (1) summary
    cd00213
    Location:3 → 88
    S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

  2. XM_063281598.1 → XP_063137668.1  protein S100-A5 isoform X1

    UniProtKB/Swiss-Prot
    P63083
    UniProtKB/TrEMBL
    A6J6P8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63083.1 GenPept UniProtKB/Swiss-Prot:P63083

Gene LinkOut

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