Smc4 structural maintenance of chromosomes 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Smc4provided by RGD
Official Full Name: structural maintenance of chromosomes 4provided by RGD
Primary source: RGD:1306680
See related: EnsemblRapid:ENSRNOG00000010274 AllianceGenome:RGD:1306680
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Smc4l1
Summary: Predicted to enable chromatin binding activity and single-stranded DNA binding activity. Predicted to be involved in mitotic chromosome condensation; positive regulation of chromosome condensation; and regulation of chromosome segregation. Predicted to act upstream of or within kinetochore organization; meiotic chromosome condensation; and meiotic chromosome segregation. Predicted to be located in chromosome, centromeric region; cytosol; and nuclear lumen. Predicted to be part of condensin complex. Orthologous to human SMC4 (structural maintenance of chromosomes 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 524.1), Spleen (RPKM 354.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q32

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (155550262..155578695)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (153240243..153268722)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (165600934..165629415)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within kinetochore organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within meiotic chromosome condensation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within meiotic chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in mitotic chromosome condensation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chromosome condensation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chromosome separation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
part_of condensin complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: structural maintenance of chromosomes protein 4

Names: SMC4 structural maintenance of chromosomes 4-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037185.2 → NP_001032262.2 structural maintenance of chromosomes protein 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

F1MAD9

Related

ENSRNOP00000079265.2, ENSRNOT00000118419.2

Conserved Domains (4) summary

cd03274
Location:80 → 239

ABC_SMC4_euk; ATP-binding cassette domain of eukaryotic SMC4 proteins

smart00968
Location:611 → 725

SMC_hinge; SMC proteins Flexible Hinge Domain

pfam02463
Location:81 → 1272

SMC_N; RecF/RecN/SMC N terminal domain

cl12013
Location:335 → 414

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature