Dync1h1 dynein cytoplasmic 1 heavy chain 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dync1h1provided by RGD
Official Full Name: dynein cytoplasmic 1 heavy chain 1provided by RGD
Primary source: RGD:2511
See related: EnsemblRapid:ENSRNOG00000006178 AllianceGenome:RGD:2511
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DHC1a; Dnch1; Dnchc1
Summary: Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in cellular response to 3,3',5-triiodo-L-thyronine; cellular response to nerve growth factor stimulus; and spermatid development. Located in several cellular components, including manchette; neuronal cell body; and nuclear envelope. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2O; autosomal dominant non-syndromic intellectual disability 13; and spinal muscular atrophy with lower extremity predominance 1. Orthologous to human DYNC1H1 (dynein cytoplasmic 1 heavy chain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 662.7), Kidney (RPKM 563.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 78

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (135436375..135502117)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (129615208..129680888)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (134958854..135085769)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High intensity interval training (HIIT) is associated with the down-regulation of gene and protein levels of KIF5B and Dynein in the rat hippocampal tissue, although the underlying mechanisms have remained unknown. These changes suggest that HIIT may have negative effects on both the anterograde and retrograde cytoplasmic transports because the cytoplasmic transport is mediated by KIF5B and Dynein.
Title: High intensity interval training decreases the expressions of KIF5B and Dynein in Hippocampus of Wistar male rats.
functional differences between yeast and mammalian dynein are real and attributable to a C-terminal motor element absent in yeast, which resembles a 'cap' over the central pore of the mammalian dynein motor domain.
Title: Control of cytoplasmic dynein force production and processivity by its C-terminal domain.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dync1h1 (e-PCR), detects polymorphism
- UniSTS:534555

D6Wox27 (e-PCR)
- UniSTS:518598

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables dynein light intermediate chain binding	ISO Inferred from Sequence Orthology more info
enables minus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables minus-end-directed microtubule motor activity	IEA Inferred from Electronic Annotation more info
contributes_to minus-end-directed microtubule motor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in P-body assembly	IEA Inferred from Electronic Annotation more info
involved_in P-body assembly	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to 3,3',5-triiodo-L-thyronine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nerve growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of spindle localization	IEA Inferred from Electronic Annotation more info
involved_in establishment of spindle localization	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of intracellular transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intracellular transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of spindle assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of spindle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of metaphase plate congression	IEA Inferred from Electronic Annotation more info
involved_in regulation of metaphase plate congression	ISO Inferred from Sequence Orthology more info
involved_in regulation of metaphase plate congression	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitotic spindle organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic spindle organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in retrograde axonal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatid development	IEP Inferred from Expression Pattern more info	PubMed
involved_in stress granule assembly	IEA Inferred from Electronic Annotation more info
involved_in stress granule assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	IEA Inferred from Electronic Annotation more info
part_of cytoplasmic dynein complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
part_of dynein complex	IEA Inferred from Electronic Annotation more info
part_of dynein complex	ISO Inferred from Sequence Orthology more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in manchette	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cytoplasmic dynein 1 heavy chain 1

Names: MAP 1C; cytoplasmic dynein heavy chain 1; dynein heavy chain, cytosolic; dynein, cytoplasmic, heavy chain 1; microtubule-associated protein 1 C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019226.3 → NP_062099.3 cytoplasmic dynein 1 heavy chain 1

See identical proteins and their annotated locations for NP_062099.3

Status: PROVISIONAL

Source sequence(s)

L08505

UniProtKB/TrEMBL

A6KBM1, M0R9X8

Related

ENSRNOP00000066312.3, ENSRNOT00000073950.5

Conserved Domains (7) summary

COG5245
Location:1044 → 4327

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam03028
Location:3920 → 4630

Dynein_heavy; Dynein heavy chain and region D6 of dynein motor

pfam08385
Location:238 → 830

DHC_N1; Dynein heavy chain, N-terminal region 1

pfam08393
Location:1321 → 1719

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12777
Location:3199 → 3530

MT; Microtubule-binding stalk of dynein motor

pfam12781
Location:3559 → 3774

AAA_9; ATP-binding dynein motor region D5

cl21455
Location:1866 → 2103

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

135436375..135502117

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111848.2 → XP_038967776.1 cytoplasmic dynein 1 heavy chain 1 isoform X1

UniProtKB/TrEMBL

M0R9X8

Conserved Domains (3) summary

COG5245
Location:1044 → 4326

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam08385
Location:240 → 830

DHC_N1; Dynein heavy chain, N-terminal region 1

pfam18199
Location:4330 → 4641

Dynein_C; Dynein heavy chain C-terminal domain