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Ranbp2 RAN binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294429, updated on 18-Sep-2024

Summary

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Official Symbol
Ranbp2provided by RGD
Official Full Name
RAN binding protein 2provided by RGD
Primary source
RGD:1560047
See related
EnsemblRapid:ENSRNOG00000000796 AllianceGenome:RGD:1560047
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560047
Summary
Predicted to enable SUMO ligase activity and small GTPase binding activity. Predicted to contribute to GTPase activator activity. Involved in response to amphetamine. Located in cytoplasmic periphery of the nuclear pore complex. Part of nuclear pore cytoplasmic filaments. Human ortholog(s) of this gene implicated in brain disease and inflammatory myofibroblastic tumor. Orthologous to human RANBP2 (RAN binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 581.3), Thymus (RPKM 505.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ranbp2 in Genome Data Viewer
Location:
20q11
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (26984520..27036573)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (26442156..26493481)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (28027054..28076664) , (28365538..28375676)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene LIM zinc finger domain containing 1 Neighboring gene small nucleolar RNA SNORD113/SNORD114 family Neighboring gene uncharacterized LOC134483907 Neighboring gene coiled-coil domain containing 138 Neighboring gene ectodysplasin-A receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Fusion of ALK to the Ran-binding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor. Ma Z, et al. Genes Chromosomes Cancer, 2003 May. PMID 12661011
  2. Cellular distribution of AMPA receptor subunits and mGlu5 following acute and repeated administration of morphine or methamphetamine. Herrold AA, et al. J Neurochem, 2013 Aug. PMID 23711322
  3. Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Cho KI, et al. Cell Mol Life Sci, 2012 Oct. PMID 22821000, Free PMC Article
  4. Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2. Neilson DE, et al. Am J Hum Genet, 2009 Jan. PMID 19118815, Free PMC Article
  5. In situ SUMOylation analysis reveals a modulatory role of RanBP2 in the nuclear rim and PML bodies. Saitoh N, et al. Exp Cell Res, 2006 May 1. PMID 16688858

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. binding of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function
    Title: Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables SUMO transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NLS-bearing protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in centrosome localization ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear export ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of glucokinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein sumoylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in response to amphetamine IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of SUMO ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in annulate lamellae ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic periphery of the nuclear pore complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear inclusion body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore cytoplasmic filaments IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore cytoplasmic filaments ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore nuclear basket ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 SUMO-protein ligase RanBP2
NP_001178533.1
XP_038954525.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191604.1 → NP_001178533.1  E3 SUMO-protein ligase RanBP2

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    M0R3M4
    Related
    ENSRNOP00000063941.2, ENSRNOT00000071386.5
    Conserved Domains (12) summary
    TIGR02795
    Location:32 → 138
    tol_pal_ybgF; tol-pal system protein YbgF
    cd01926
    Location:2928 → 3086
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    cd13177
    Location:1902 → 2018
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:2789 → 2905
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14684
    Location:1180 → 1296
    RanBD1_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 1
    cd14685
    Location:2199 → 2315
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00025
    Location:1350 → 1369
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00006
    Location:59 → 89
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:60 → 92
    TPR_1; Tetratricopeptide repeat
    pfam00641
    Location:1473 → 1502
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam12185
    Location:2579 → 2638
    IR1-M; Nup358/RanBP2 E3 ligase domain
    cl23782
    Location:839 → 925
    RCR; Chitin synthesis regulation, resistance to Congo red

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    26984520..27036573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098597.2 → XP_038954525.1  E3 SUMO-protein ligase RanBP2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5YC36, M0R3M4
    Related
    ENSRNOP00000077936.1, ENSRNOT00000114220.2
    Conserved Domains (10) summary
    COG0457
    Location:18 → 126
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    cd01926
    Location:2954 → 3112
    cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
    cd13177
    Location:1902 → 2018
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd13178
    Location:2815 → 2931
    RanBD4_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 4
    cd14684
    Location:1180 → 1296
    RanBD1_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 1
    cd14685
    Location:2199 → 2315
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00025
    Location:1350 → 1369
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00006
    Location:59 → 89
    TPR; TPR repeat [structural motif]
    pfam00641
    Location:1473 → 1502
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam12185
    Location:2605 → 2663
    IR1-M; Nup358/RanBP2 E3 ligase domain
Nucleotide Protein Strain
Heading Accession and Version

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