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Celf2 CUGBP, Elav-like family member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29428, updated on 6-Jun-2024

Summary

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Official Symbol
Celf2provided by RGD
Official Full Name
CUGBP, Elav-like family member 2provided by RGD
Primary source
RGD:68347
See related
Ensembl:ENSRNOG00000023661 AllianceGenome:RGD:68347
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Etr3; Napor; Cugbp2; Brunol3
Summary
Enables mRNA 3'-UTR binding activity. Involved in posttranscriptional gene silencing. Predicted to be located in Flemming body and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human CELF2 (CUGBP Elav-like family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 283.6), Spleen (RPKM 168.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Celf2 in Genome Data Viewer
Location:
17q12.3
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (75813928..76639300)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (70904462..71729072)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (75259269..75660154)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene nucleophosmin 1, pseudogene 16 Neighboring gene small nuclear ribonucleoprotein polypeptide E, pseudogene 2 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102547255 Neighboring gene uncharacterized LOC134482740 Neighboring gene uncharacterized LOC108348587 Neighboring gene uncharacterized LOC134482604 Neighboring gene uncharacterized LOC134482603

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Microarray analysis of neonatal rat anteroventral periventricular transcriptomes identifies the proapoptotic Cugbp2 gene as sex-specific and regulated by estradiol. Del Pino Sans J, et al. Neuroscience, 2015 Sep 10. PMID 26166732
  2. A novel function for CUGBP2 in controlling the pro-inflammatory stimulus in H9c2 cells: subcellular trafficking of messenger molecules. Moraes KC, et al. Cell Biol Int, 2013 Oct. PMID 23661609
  3. NAPOR-3 RNA binding protein is required for apoptosis in hippocampus. Pacini A, et al. Brain Res Mol Brain Res, 2005 Oct 31. PMID 16095752
  4. Etr-r3/mNapor, encoding an ELAV-type RNA binding protein, is expressed in differentiating cells in the developing rodent forebrain. Levers TE, et al. Mech Dev, 2002 Mar. PMID 11850193
  5. Platelet-derived growth factor-induced stabilization of cyclooxygenase 2 mRNA in rat smooth muscle cells requires the c-Src family of protein-tyrosine kinases. Xu K, et al. J Biol Chem, 2007 Nov 9. PMID 17855367

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonstrated that Cugbp2 regulates splicing and translation of mRNAs linked to sexual differentiation in rats.
    Title: Microarray analysis of neonatal rat anteroventral periventricular transcriptomes identifies the proapoptotic Cugbp2 gene as sex-specific and regulated by estradiol.
  2. a regulatory connection between COX-2 and CUGBP2 in the cardiac cells, was demonstrated.
    Title: A novel function for CUGBP2 in controlling the pro-inflammatory stimulus in H9c2 cells: subcellular trafficking of messenger molecules.
  3. NAPOR-3 gene overexpression is necessary for the execution of oxygen glucose deprivation-induced programmed cell death.
    Title: NAPOR-3 RNA binding protein is required for apoptosis in hippocampus.
  4. These findings identify a novel paradigm for RNA binding proteins such as CUGBP2 in facilitating opposing functions of mRNA stability and translation inhibition and reveal a mechanism for inhibiting cyclooxygenase-2 expression in cancer cells.
    Title: Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2.
  5. Etr-r3/mNapor, encoding an ELAV-type RNA binding protein, is expressed in differentiating cells in the developing rodent forebrain
    Title: Etr-r3/mNapor, encoding an ELAV-type RNA binding protein, is expressed in differentiating cells in the developing rodent forebrain.
  6. tissue-specific distribution of NAPOR, CUG-BP, and other highly related proteins within the nervous system
    Title: Region-specific alternative splicing in the nervous system: implications for regulation by the RNA-binding protein NAPOR.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables lncRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables lncRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pre-mRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splice site recognition IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA splice site recognition ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splice site recognition ISO
Inferred from Sequence Orthology
more info
  
involved_in post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Flemming body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CUGBP Elav-like family member 2
Names
CUG triplet repeat, RNA binding protein 2
CUG-BP- and ETR-3-like factor 2
Cugbp- and Etr3-like factor 2
RNA-binding protein BRUNOL-3
RNA-binding protein Brunol3
bruno-like protein 3
elav-type RNA-binding protein 3
neuroblastoma apoptosis-related RNA-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083586.3 → NP_001077055.2  CUGBP Elav-like family member 2 isoform 2

    See identical proteins and their annotated locations for NP_001077055.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    A1L1J5, O88756, Q78ZF0, Q792H5
    UniProtKB/TrEMBL
    A6JLW4
    Related
    ENSRNOP00000023436.5, ENSRNOT00000023436.5
    Conserved Domains (3) summary
    cd12638
    Location:434 → 525
    RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12631
    Location:57 → 140
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:149 → 229
    RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

  2. NM_017197.4 → NP_058893.2  CUGBP Elav-like family member 2 isoform 1

    See identical proteins and their annotated locations for NP_058893.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    A1L1J5, O88756, Q78ZF0, Q792H5
    Conserved Domains (3) summary
    cd12638
    Location:440 → 531
    RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12631
    Location:57 → 140
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:149 → 229
    RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    75813928..76639300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276301.1 → XP_063132371.1  CUGBP Elav-like family member 2 isoform X13

  2. XM_063276302.1 → XP_063132372.1  CUGBP Elav-like family member 2 isoform X15

    UniProtKB/TrEMBL
    Z4YNP1

  3. XM_063276304.1 → XP_063132374.1  CUGBP Elav-like family member 2 isoform X17

    UniProtKB/TrEMBL
    Z4YNP1

  4. XM_063276305.1 → XP_063132375.1  CUGBP Elav-like family member 2 isoform X17

    UniProtKB/TrEMBL
    Z4YNP1

  5. XM_063276307.1 → XP_063132377.1  CUGBP Elav-like family member 2 isoform X20

    UniProtKB/TrEMBL
    Z4YNP1

  6. XM_063276308.1 → XP_063132378.1  CUGBP Elav-like family member 2 isoform X20

    UniProtKB/TrEMBL
    Z4YNP1

  7. XM_063276290.1 → XP_063132360.1  CUGBP Elav-like family member 2 isoform X1

  8. XM_063276289.1 → XP_063132359.1  CUGBP Elav-like family member 2 isoform X1

  9. XM_063276292.1 → XP_063132362.1  CUGBP Elav-like family member 2 isoform X3

    UniProtKB/TrEMBL
    Z4YNP1

  10. XM_039095585.2 → XP_038951513.2  CUGBP Elav-like family member 2 isoform X6

  11. XM_063276293.1 → XP_063132363.1  CUGBP Elav-like family member 2 isoform X4

    UniProtKB/TrEMBL
    Z4YNP1

  12. XM_063276294.1 → XP_063132364.1  CUGBP Elav-like family member 2 isoform X4

    UniProtKB/TrEMBL
    Z4YNP1

  13. XM_063276291.1 → XP_063132361.1  CUGBP Elav-like family member 2 isoform X2

    UniProtKB/TrEMBL
    Z4YNP1

  14. XM_063276295.1 → XP_063132365.1  CUGBP Elav-like family member 2 isoform X5

    UniProtKB/TrEMBL
    Z4YNP1

  15. XM_063276296.1 → XP_063132366.1  CUGBP Elav-like family member 2 isoform X5

    UniProtKB/TrEMBL
    Z4YNP1

  16. XM_063276297.1 → XP_063132367.1  CUGBP Elav-like family member 2 isoform X5

    UniProtKB/TrEMBL
    Z4YNP1

  17. XM_063276298.1 → XP_063132368.1  CUGBP Elav-like family member 2 isoform X7

  18. XM_008771863.4 → XP_008770085.2  CUGBP Elav-like family member 2 isoform X10

    UniProtKB/TrEMBL
    Z4YNP1

  19. XM_063276299.1 → XP_063132369.1  CUGBP Elav-like family member 2 isoform X8

    UniProtKB/TrEMBL
    Z4YNP1

  20. XM_063276300.1 → XP_063132370.1  CUGBP Elav-like family member 2 isoform X12

    UniProtKB/TrEMBL
    A0A8I5ZWV8, Z4YNP1

  21. XM_039095591.2 → XP_038951519.1  CUGBP Elav-like family member 2 isoform X19

    Related
    ENSRNOP00000078975.1
    Conserved Domains (3) summary
    cd12638
    Location:438 → 529
    RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12631
    Location:51 → 134
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:143 → 223
    RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

  22. XM_063276310.1 → XP_063132380.1  CUGBP Elav-like family member 2 isoform X22

    UniProtKB/TrEMBL
    A0A8I6G2N0, Z4YNP1

  23. XM_063276311.1 → XP_063132381.1  CUGBP Elav-like family member 2 isoform X22

    UniProtKB/TrEMBL
    A0A8I6G2N0, Z4YNP1

  24. XM_063276309.1 → XP_063132379.1  CUGBP Elav-like family member 2 isoform X21

    UniProtKB/TrEMBL
    Z4YNP1

  25. XM_063276314.1 → XP_063132384.1  CUGBP Elav-like family member 2 isoform X24

    UniProtKB/TrEMBL
    Z4YNP1

  26. XM_063276315.1 → XP_063132385.1  CUGBP Elav-like family member 2 isoform X24

    UniProtKB/TrEMBL
    Z4YNP1

  27. XM_063276324.1 → XP_063132394.1  CUGBP Elav-like family member 2 isoform X33

    UniProtKB/TrEMBL
    A0A8I6GLG1, Z4YNP1

  28. XM_063276318.1 → XP_063132388.1  CUGBP Elav-like family member 2 isoform X26

    UniProtKB/TrEMBL
    Z4YNP1

  29. XM_063276306.1 → XP_063132376.1  CUGBP Elav-like family member 2 isoform X18

    UniProtKB/Swiss-Prot
    A1L1J5, O88756, Q78ZF0, Q792H5

  30. XM_063276322.1 → XP_063132392.1  CUGBP Elav-like family member 2 isoform X30

    UniProtKB/Swiss-Prot
    A1L1J5, O88756, Q78ZF0, Q792H5

  31. XM_063276303.1 → XP_063132373.1  CUGBP Elav-like family member 2 isoform X16

    UniProtKB/Swiss-Prot
    A1L1J5, O88756, Q78ZF0, Q792H5

  32. XM_063276321.1 → XP_063132391.1  CUGBP Elav-like family member 2 isoform X29

    UniProtKB/Swiss-Prot
    A1L1J5, O88756, Q78ZF0, Q792H5

  33. XM_063276327.1 → XP_063132397.1  CUGBP Elav-like family member 2 isoform X29

    UniProtKB/Swiss-Prot
    A1L1J5, O88756, Q78ZF0, Q792H5

  34. XM_063276320.1 → XP_063132390.1  CUGBP Elav-like family member 2 isoform X28

    UniProtKB/Swiss-Prot
    A1L1J5, O88756, Q78ZF0, Q792H5
    UniProtKB/TrEMBL
    A6JLW4

  35. XM_039095604.2 → XP_038951532.1  CUGBP Elav-like family member 2 isoform X31

    UniProtKB/Swiss-Prot
    A1L1J5, O88756, Q78ZF0, Q792H5
    UniProtKB/TrEMBL
    A0A8I5ZJI1
    Related
    ENSRNOP00000077512.1
    Conserved Domains (4) summary
    TIGR01661
    Location:60 → 473
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12631
    Location:57 → 140
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:149 → 229
    RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cl17169
    Location:437 → 477
    RRM_SF; RNA recognition motif (RRM) superfamily

  36. XM_039095586.2 → XP_038951514.1  CUGBP Elav-like family member 2 isoform X9

    Conserved Domains (3) summary
    cd12638
    Location:454 → 545
    RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12631
    Location:67 → 150
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:159 → 239
    RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

  37. XM_008771862.4 → XP_008770084.2  CUGBP Elav-like family member 2 isoform X11

    UniProtKB/TrEMBL
    Z4YNP1

  38. XM_039095584.2 → XP_038951512.2  CUGBP Elav-like family member 2 isoform X14

    UniProtKB/TrEMBL
    Z4YNP1

  39. XM_008771864.4 → XP_008770086.2  CUGBP Elav-like family member 2 isoform X14

    UniProtKB/TrEMBL
    Z4YNP1

  40. XM_063276316.1 → XP_063132386.1  CUGBP Elav-like family member 2 isoform X25

    UniProtKB/TrEMBL
    Z4YNP1

  41. XM_063276317.1 → XP_063132387.1  CUGBP Elav-like family member 2 isoform X25

    UniProtKB/TrEMBL
    Z4YNP1

  42. XM_063276325.1 → XP_063132395.1  CUGBP Elav-like family member 2 isoform X34

    UniProtKB/TrEMBL
    Z4YNP1

  43. XM_039095594.2 → XP_038951522.1  CUGBP Elav-like family member 2 isoform X23

    UniProtKB/TrEMBL
    A0A8I5ZWW9, Z4YNP1
    Related
    ENSRNOP00000084295.1
    Conserved Domains (3) summary
    cd12638
    Location:429 → 520
    RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12631
    Location:46 → 129
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:138 → 218
    RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

  44. XM_063276313.1 → XP_063132383.1  CUGBP Elav-like family member 2 isoform X23

    UniProtKB/TrEMBL
    A0A8I5ZWW9, Z4YNP1

  45. XM_063276323.1 → XP_063132393.1  CUGBP Elav-like family member 2 isoform X32

    UniProtKB/TrEMBL
    Z4YNP1

  46. XM_039095595.2 → XP_038951523.1  CUGBP Elav-like family member 2 isoform X27

    UniProtKB/TrEMBL
    Z4YNP1
    Conserved Domains (3) summary
    cd12638
    Location:423 → 514
    RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
    cd12631
    Location:46 → 129
    RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
    cd12634
    Location:138 → 218
    RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

  47. XM_063276319.1 → XP_063132389.1  CUGBP Elav-like family member 2 isoform X27

    UniProtKB/TrEMBL
    Z4YNP1

  48. XM_063276326.1 → XP_063132396.1  CUGBP Elav-like family member 2 isoform X35

    UniProtKB/TrEMBL
    Z4YNP1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q792H5.1 GenPept UniProtKB/Swiss-Prot:Q792H5

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