Pax2 paired box 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293992, updated on 2-Nov-2024

Summary

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Official Symbol: Pax2provided by RGD
Official Full Name: paired box 2provided by RGD
Primary source: RGD:1305568
See related: EnsemblRapid:ENSRNOG00000014253 AllianceGenome:RGD:1305568
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pax-2
Summary: Predicted to enable C2H2 zinc finger domain binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to epidermal growth factor stimulus; positive regulation of cell population proliferation; and response to nutrient levels. Predicted to be located in centriolar satellite and nucleoplasm. Predicted to be part of protein-DNA complex. Biomarker of nephroblastoma. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 7; renal Wilms' tumor; and renal coloboma syndrome. Orthologous to human PAX2 (paired box 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 31.6) See more
Orthologs: human mouse all
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Genomic context

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See Pax2 in Genome Data Viewer

Location:: 1q54

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (253555447..253646623)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (243616509..243697454)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (264493579..264585073)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pax2 overexpression by kidney tubule cells alters the expression of complement system proteins to induce epithelial-mesenchymal transition.
Title: Screening of genes involved in epithelial-mesenchymal transition and differential expression of complement-related genes induced by PAX2 in renal tubules.
PAX2 directly increased expression of ADAM10, the presence of which contributed to EMT in renal tubular epithelia and hence plays an important role in renal fibrosis.
Title: PAX2 may induce ADAM10 expression in renal tubular epithelial cells and contribute to epithelial-to-mesenchymal transition.
Persistent Pax2 expression may be required to maintain a GABAergic phenotype.
Title: Pax2 is persistently expressed by GABAergic neurons throughout the adult rat dorsal horn.
Activin A regulates tubular cell growth and differentiation by modulating the expression of Pax-2 during regeneration.
Title: Involvement of Pax-2 in the action of activin A on tubular cell regeneration.
Those findings suggest that mature TECs can trans-differentiate into progenitor-like cells by "atavistic transition", which may participate in the recovery of tissue structure and Pax2 may play a pivotal role in this process.
Title: Cell atavistic transition: Paired box 2 re-expression occurs in mature tubular epithelial cells during acute kidney injury and is regulated by Angiotensin II.
There might be a potential signaling pathway between PAX2 and CD2AP in RIF disease. Further research is needed to determine the association in RIF disease.
Title: The potential signal pathway between PAX2 and CD2AP in the renal interstitial fibrosis disease.
PAX2 induces renal tubular mesenchymal transition in vitro.
Title: Paired box 2 induces epithelial-mesenchymal transition in normal renal tubular epithelial cells of rats.
ATRA increases the number of glomerular epithelial transition cells in experimental proteinuric glomerular diseases. Thus, ATRA may provide a useful pharmacologic approach to decipher the
Title: Retinoids augment the expression of podocyte proteins by glomerular parietal epithelial cells in experimental glomerular disease.
The re-expression of WT1 and Pax2 in the tubular epithelial cells plays important roles in the promotion of epithelial-mesenchymal transition.
Title: WT1 and Pax2 re-expression is required for epithelial-mesenchymal transition in 5/6 nephrectomized rats and cultured kidney tubular epithelial cells.
In rats with obstructive nephropathy, embryonic development gene PAX2 is re-expressed in the renal tubules, which may participate in the pathogenesis of renal tubular damage and renal interstitial fibrosis.
Title: PAX2 re-expression in renal tubular epithelial cells and correlation with renal interstitial fibrosis of rats with obstructive nephropathy.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

RH80285 (e-PCR)
- UniSTS:88437

D11Bir2 (e-PCR), detects polymorphism
- UniSTS:141710

Pax2 (e-PCR), detects polymorphism
- UniSTS:470672

PMC19453P1 (e-PCR)
- UniSTS:271774

NoName (e-PCR)
- UniSTS:482033

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables C2H2 zinc finger domain binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in brain morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in brain morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in camera-type eye development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell fate determination	ISO Inferred from Sequence Orthology more info
involved_in cell fate determination	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to epidermal growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	ISS Inferred from Sequence or Structural Similarity more info
involved_in central nervous system development	ISO Inferred from Sequence Orthology more info
involved_in cochlea development	ISO Inferred from Sequence Orthology more info
involved_in cochlea development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cochlea morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cochlea morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cochlea morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in glial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in inner ear morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesenchymal to epithelial transition	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal to epithelial transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in mesenchymal to epithelial transition involved in metanephros morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal to epithelial transition involved in metanephros morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mesodermal cell fate specification	ISO Inferred from Sequence Orthology more info
involved_in mesodermal cell fate specification	ISS Inferred from Sequence or Structural Similarity more info
involved_in mesonephric duct development	ISO Inferred from Sequence Orthology more info
involved_in mesonephric tubule development	ISO Inferred from Sequence Orthology more info
involved_in mesonephric tubule formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesonephros development	ISO Inferred from Sequence Orthology more info
involved_in mesonephros development	ISO Inferred from Sequence Orthology more info
involved_in mesonephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric collecting duct development	ISO Inferred from Sequence Orthology more info
involved_in metanephric collecting duct development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric distal convoluted tubule development	ISO Inferred from Sequence Orthology more info
involved_in metanephric distal convoluted tubule development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric epithelium development	ISO Inferred from Sequence Orthology more info
involved_in metanephric mesenchymal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in metanephric mesenchymal cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric mesenchyme development	ISO Inferred from Sequence Orthology more info
involved_in metanephric mesenchyme development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric nephron tubule formation	ISO Inferred from Sequence Orthology more info
involved_in metanephric nephron tubule formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within metanephros development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process involved in metanephric collecting duct development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process involved in metanephric collecting duct development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process involved in metanephric nephron tubule development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process involved in metanephric nephron tubule development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mesenchymal cell apoptotic process involved in metanephros development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mesenchymal cell apoptotic process involved in metanephros development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of programmed cell death	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in nephric duct formation	ISO Inferred from Sequence Orthology more info
involved_in nephric duct formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in neural tube closure	ISS Inferred from Sequence or Structural Similarity more info
involved_in optic chiasma development	ISO Inferred from Sequence Orthology more info
involved_in optic chiasma development	ISS Inferred from Sequence or Structural Similarity more info
involved_in optic cup morphogenesis involved in camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in optic cup morphogenesis involved in camera-type eye development	ISS Inferred from Sequence or Structural Similarity more info
involved_in optic nerve development	ISO Inferred from Sequence Orthology more info
involved_in optic nerve development	ISS Inferred from Sequence or Structural Similarity more info
involved_in optic nerve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in optic nerve morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in optic nerve structural organization	ISO Inferred from Sequence Orthology more info
involved_in optic nerve structural organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in pancreas development	ISO Inferred from Sequence Orthology more info
involved_in paramesonephric duct development	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of metanephric DCT cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of metanephric DCT cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of metanephric glomerulus development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of metanephric glomerulus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of optic nerve formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of optic nerve formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in pronephric field specification	ISO Inferred from Sequence Orthology more info
involved_in pronephric field specification	ISS Inferred from Sequence or Structural Similarity more info
involved_in pronephros development	ISO Inferred from Sequence Orthology more info
involved_in pronephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of metanephric nephron tubule epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of metanephric nephron tubule epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of metanephros size	ISO Inferred from Sequence Orthology more info
involved_in regulation of metanephros size	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinal pigment epithelium development	ISO Inferred from Sequence Orthology more info
involved_in retinal pigment epithelium development	ISS Inferred from Sequence or Structural Similarity more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in stem cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in ureter development	ISO Inferred from Sequence Orthology more info
involved_in ureter development	ISS Inferred from Sequence or Structural Similarity more info
involved_in ureter maturation	ISO Inferred from Sequence Orthology more info
involved_in ureter maturation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ureter morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ureter morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ureteric bud development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within urogenital system development	ISO Inferred from Sequence Orthology more info
involved_in urogenital system development	ISO Inferred from Sequence Orthology more info
involved_in urogenital system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in vestibulocochlear nerve formation	ISO Inferred from Sequence Orthology more info
involved_in vestibulocochlear nerve formation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: paired box protein Pax-2

Names: paired box gene 2; paired box homeotic gene 2; paired box protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106361.1 → NP_001099831.1 paired box protein Pax-2

See identical proteins and their annotated locations for NP_001099831.1

Status: PROVISIONAL

Source sequence(s)

CH473986

UniProtKB/TrEMBL

A6JHG7, D4ACZ2

Related

ENSRNOP00000040130.4, ENSRNOT00000050076.6

Conserved Domains (3) summary

smart00351
Location:15 → 139

PAX; Paired Box domain

pfam12403
Location:304 → 414

Pax2_C; Paired-box protein 2 C terminal

cl00084
Location:254 → 277

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

253555447..253646623

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287134.1 → XP_063143204.1 paired box protein Pax-2 isoform X1

Related

ENSRNOP00000070907.3, ENSRNOT00000085811.3
XM_039109033.2 → XP_038964961.1 paired box protein Pax-2 isoform X4

Conserved Domains (3) summary

smart00351
Location:15 → 139

PAX; Paired Box domain

pfam12403
Location:281 → 366

Pax2_C; Paired-box protein 2 C terminal

cl00084
Location:231 → 254

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_006231443.4 → XP_006231505.2 paired box protein Pax-2 isoform X5

Related

ENSRNOP00000105134.1, ENSRNOT00000138817.1
XM_039109046.1 → XP_038964974.1 paired box protein Pax-2 isoform X6

Conserved Domains (3) summary

smart00351
Location:15 → 139

PAX; Paired Box domain

pfam12403
Location:281 → 391

Pax2_C; Paired-box protein 2 C terminal

cl00084
Location:231 → 254

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
XM_063287138.1 → XP_063143208.1 paired box protein Pax-2 isoform X2
XM_039109034.1 → XP_038964962.1 paired box protein Pax-2 isoform X3

Related

ENSRNOP00000104618.1, ENSRNOT00000129655.1

Conserved Domains (3) summary

smart00351
Location:16 → 140

PAX; Paired Box domain

pfam12403
Location:282 → 367

Pax2_C; Paired-box protein 2 C terminal

cl00084
Location:232 → 255

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.