Lrp5 LDL receptor related protein 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrp5provided by RGD
Official Full Name: LDL receptor related protein 5provided by RGD
Primary source: RGD:1309329
See related: EnsemblRapid:ENSRNOG00000015911 AllianceGenome:RGD:1309329
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable Wnt receptor activity; Wnt-protein binding activity; and coreceptor activity. Involved in response to peptide hormone and retina vasculature morphogenesis in camera-type eye. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Used to study autosomal dominant polycystic kidney disease and polycystic liver disease 1. Biomarker of osteonecrosis; osteoporosis; and tendinitis. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease (multiple). Orthologous to several human genes including LRP5 (LDL receptor related protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 424.1), Liver (RPKM 180.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q42-q43

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (210243499..210346886, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (200814247..200917581, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (218816833..218920147, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure and function of the retina of low-density lipoprotein receptor-related protein 5 (Lrp5)-deficient rats.
Title: Structure and function of the retina of low-density lipoprotein receptor-related protein 5 (Lrp5)-deficient rats.
Low-Density Lipoprotein Receptor-Related Protein 5-Deficient Rats Have Reduced Bone Mass and Abnormal Development of the Retinal Vasculature.
Title: Low-Density Lipoprotein Receptor-Related Protein 5-Deficient Rats Have Reduced Bone Mass and Abnormal Development of the Retinal Vasculature.
LRP5 Regulates HIF-1alpha Stability via Interaction with PHD2 in Ischemic Myocardium.
Title: LRP5 Regulates HIF-1α Stability via Interaction with PHD2 in Ischemic Myocardium.
study demonstrates that LRP5/6 mediates pulmonary vascular remodeling and PH in hyperoxia-induced neonatal lung injury
Title: Inhibition of LRP5/6-mediated Wnt/β-catenin signaling by Mesd attenuates hyperoxia-induced pulmonary hypertension in neonatal rats.
Mechanotransduction in osteoblastic cells involves strain-regulated ESRalpha-mediated control of IGFI receptor sensitivity to Ambient IGF, leading to PI3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling
Title: Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling.
Modulation of sclerostin levels appears to be a finely tuned mechanism by which osteocytes coordinate regional and local osteogenesis in response to increased mechanical stimulation, perhaps via releasing the local inhibition of Wnt/Lrp5 signaling
Title: Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin.
1,25(OH)(2)D(3) can enhance the expression of a critical component of the Wnt signaling pathway which is known to impact osteogenesis
Title: 1,25-Dihydroxyvitamin D3 induces expression of the Wnt signaling co-regulator LRP5 via regulatory elements located significantly downstream of the gene's transcriptional start site.

Submit: New GeneRIF Correction

General gene information

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Markers

AF064984 (e-PCR)
- UniSTS:160771

Lrp5 (e-PCR), detects polymorphism
- UniSTS:516484

Lrp5 (e-PCR), detects polymorphism
- UniSTS:508399

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Wnt receptor activity	ISO Inferred from Sequence Orthology more info
enables Wnt-protein binding	ISO Inferred from Sequence Orthology more info
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
NOT enables toxin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Norrin signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adipose tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amino acid transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anatomical structure regression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in bone development	ISO Inferred from Sequence Orthology more info
involved_in bone marrow development	ISO Inferred from Sequence Orthology more info
involved_in bone morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell migration involved in gastrulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell signaling involved in mammary gland development	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of blood-brain barrier	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of blood-retinal barrier	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix-cell signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gastrulation with mouth forming second	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in glucose catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within limb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland duct morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesodermal cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within osteoblast development	ISO Inferred from Sequence Orthology more info
involved_in osteoblast development	ISO Inferred from Sequence Orthology more info
acts_upstream_of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
NOT involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in retina morphogenesis in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina vasculature development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in retina vasculature morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina vasculature morphogenesis in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in retinal blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculature development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: low-density lipoprotein receptor-related protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106321.2 → NP_001099791.2 low-density lipoprotein receptor-related protein 5 precursor

See identical proteins and their annotated locations for NP_001099791.2

Status: PROVISIONAL

Source sequence(s)

BC166786

UniProtKB/TrEMBL

A0A8I6G721, B2RYI1

Conserved Domains (6) summary

smart00135
Location:408 → 450

LY; Low-density lipoprotein-receptor YWTD domain

cd00112
Location:1321 → 1355

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd05819
Location:720 → 756

NHL; NHL repeat [structural motif]

cl18310
Location:685 → 878

NHL; NHL repeat unit of beta-propeller proteins

pfam00058
Location:163 → 203

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:299 → 336

FXa_inhibition; Coagulation Factor Xa inhibitory site