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Hs3st2 heparan sulfate-glucosamine 3-sulfotransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293451, updated on 17-Aug-2024

Summary

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Official Symbol
Hs3st2provided by RGD
Official Full Name
heparan sulfate-glucosamine 3-sulfotransferase 2provided by RGD
Primary source
RGD:727787
See related
EnsemblRapid:ENSRNOG00000017659 AllianceGenome:RGD:727787
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Involved in circadian rhythm. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in colon cancer; lung cancer; and pancreatic cancer. Orthologous to human HS3ST2 (heparan sulfate-glucosamine 3-sulfotransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 25.4) and Heart (RPKM 1.2) See more
Orthologs
human mouse all
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Genomic context

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See Hs3st2 in Genome Data Viewer
Location:
1q36
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (185387445..185508700)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (175956161..176077400)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (191344979..191474143)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349630 Neighboring gene uncharacterized LOC134483811 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 59 Neighboring gene uncharacterized LOC134483814 Neighboring gene uncharacterized LOC120099923 Neighboring gene ubiquitin specific peptidase 31

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Light-induced 3-O-sulfotransferase expression alters pineal heparan sulfate fine structure. A surprising link to circadian rhythm. Kuberan B, et al. J Biol Chem, 2004 Feb 13. PMID 14630922
  2. Diurnal pineal 3-O-sulphotransferase 2 expression controlled by beta-adrenergic repression. Borjigin J, et al. J Biol Chem, 2003 May 2. PMID 12601002
  3. Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers. Miyamoto K, et al. Oncogene, 2003 Jan 16. PMID 12527896
  4. Integrating DNA methylation and microRNA biomarkers in sputum for lung cancer detection. Su Y, et al. Clin Epigenetics, 2016. PMID 27777637, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 3-O sulfation catalyzed by HS 3-O-sulfotransferase (3-OST2) is predominantly restricted to daytime pineal glands in rats
    Title: Light-induced 3-O-sulfotransferase expression alters pineal heparan sulfate fine structure. A surprising link to circadian rhythm.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISO
Inferred from Sequence Orthology
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity TAS
Traceable Author Statement
more info
 PubMed 
enables [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in circadian rhythm IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycosaminoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosaminoglycan biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 2
Names
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
heparan sulfate 3-O-sulfotransferase 2
heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2
NP_852035.1
XP_063142029.1
XP_063142034.1
XP_063142038.1
XP_063142041.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181370.3 → NP_852035.1  heparan sulfate glucosamine 3-O-sulfotransferase 2

    See identical proteins and their annotated locations for NP_852035.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    A1A5M1, Q80W66
    UniProtKB/TrEMBL
    A6I8U4
    Related
    ENSRNOP00000023773.5, ENSRNOT00000023773.8
    Conserved Domains (1) summary
    pfam00685
    Location:114 → 351
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    185387445..185508700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285959.1 → XP_063142029.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X1

  2. XM_063285964.1 → XP_063142034.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X2

  3. XM_063285968.1 → XP_063142038.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X3

  4. XM_063285971.1 → XP_063142041.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80W66.1 GenPept UniProtKB/Swiss-Prot:Q80W66

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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