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Rlbp1 retinaldehyde binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293049, updated on 2-Nov-2024

Summary

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Official Symbol
Rlbp1provided by RGD
Official Full Name
retinaldehyde binding protein 1provided by RGD
Primary source
RGD:1309649
See related
EnsemblRapid:ENSRNOG00000016897 AllianceGenome:RGD:1309649
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 11-cis retinal binding activity and phosphatidylinositol bisphosphate binding activity. Located in cell body. Human ortholog(s) of this gene implicated in Bothnia retinal dystrophy; Newfoundland cone-rod dystrophy; fundus albipunctatus; night blindness; and retinitis pigmentosa. Orthologous to human RLBP1 (retinaldehyde binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 83.0) See more
Orthologs
human mouse all
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Genomic context

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See Rlbp1 in Genome Data Viewer
Location:
1q31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (142718262..142731621, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (133308920..133322296, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (141097789..141111375, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene abhydrolase domain containing 2, acylglycerol lipase Neighboring gene uncharacterized LOC134483740 Neighboring gene FA complementation group I Neighboring gene transfer RNA arginine (anticodon UCG) 1 Neighboring gene DNA polymerase gamma, catalytic subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. von Lintig J, et al. Trends Biochem Sci, 2010 Jul. PMID 20188572, Free PMC Article
  2. Fundus albipunctatus and retinitis punctata albescens in a pedigree with an R150Q mutation in RLBP1. Katsanis N, et al. Clin Genet, 2001 Jun. PMID 11453974
  3. Ocular phenotype of bothnia dystrophy, an autosomal recessive retinitis pigmentosa associated with an R234W mutation in the RLBP1 gene. Burstedt MS, et al. Arch Ophthalmol, 2001 Feb. PMID 11176989
  4. Mutation of the gene encoding cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa. Maw MA, et al. Nat Genet, 1997 Oct. PMID 9326942
  5. Localizations of visual cycle components in retinal pigment epithelium. Huang J, et al. Mol Vis, 2009. PMID 19180257, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 11-cis retinal binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
retinaldehyde-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106274.2 → NP_001099744.1  retinaldehyde-binding protein 1

    See identical proteins and their annotated locations for NP_001099744.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6JC48, D3Z956
    Related
    ENSRNOP00000022962.5, ENSRNOT00000022962.8
    Conserved Domains (2) summary
    smart01100
    Location:60 → 117
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam00650
    Location:143 → 292
    CRAL_TRIO; CRAL/TRIO domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    142718262..142731621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105632.2 → XP_038961560.1  retinaldehyde-binding protein 1 isoform X1

    Conserved Domains (1) summary
    pfam00650
    Location:11 → 160
    CRAL_TRIO; CRAL/TRIO domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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