Akap13 A-kinase anchoring protein 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Akap13provided by RGD
Official Full Name: A-kinase anchoring protein 13provided by RGD
Primary source: RGD:727893
See related: EnsemblRapid:ENSRNOG00000010964 AllianceGenome:RGD:727893
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AKAP-13; AKAP-Lbc
Summary: Enables MAP-kinase scaffold activity. Involved in several processes, including adrenergic receptor signaling pathway; cell growth involved in cardiac muscle cell development; and positive regulation of intracellular signal transduction. Located in perinuclear region of cytoplasm. Orthologous to human AKAP13 (A-kinase anchoring protein 13). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 290.1), Spleen (RPKM 232.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q31

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (138722445..139029401)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (129313183..129619647)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (137089558..137315272)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings identify AKAP-Lbc as a key Rho-guanine nucleotide exchange factor modulating profibrotic responses in cardiac fibroblasts.
Title: A-kinase anchoring protein-Lbc promotes pro-fibrotic signaling in cardiac fibroblasts.
activation of IKKbeta within the AKAP-Lbc complex promotes NF-kappaB-dependent production of interleukin-6, which in turn enhances fetal gene expression and cardiomyocyte growth.
Title: A-kinase-anchoring protein-Lbc anchors IκB kinase β to support interleukin-6-mediated cardiomyocyte hypertrophy.

Submit: New GeneRIF Correction

General gene information

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Markers

D1Rat183 (e-PCR)
- UniSTS:118545

AU048734 (e-PCR)
- UniSTS:145184

AI406405 (e-PCR)
- UniSTS:249982

BE120782 (e-PCR)
- UniSTS:247443

BE118168 (e-PCR)
- UniSTS:248797

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MAP-kinase scaffold activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP-kinase scaffold activity	IEA Inferred from Electronic Annotation more info
enables MAP-kinase scaffold activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables MAP-kinase scaffold activity	ISO Inferred from Sequence Orthology more info
enables MAP-kinase scaffold activity	ISS Inferred from Sequence or Structural Similarity more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase A binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	ISO Inferred from Sequence Orthology more info
involved_in adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adrenergic receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adrenergic receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in bone development	ISO Inferred from Sequence Orthology more info
involved_in bone development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear export	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of glucocorticoid mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of sarcomere organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of sarcomere organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
colocalizes_with actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISS Inferred from Sequence or Structural Similarity more info
located_in cortical actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cortical actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: A-kinase anchor protein 13

Names: A kinase (PRKA) anchor protein 13; protein kinase A anchoring protein Rt31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106271.3 → NP_001099741.2 A-kinase anchor protein 13

See identical proteins and their annotated locations for NP_001099741.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

F1M3G7, Q8VHU6

UniProtKB/TrEMBL

A0A8I6GDR4

Related

ENSRNOP00000086170.1, ENSRNOT00000103755.2

Conserved Domains (5) summary

smart00109
Location:1754 → 1800

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

cd00160
Location:1957 → 2151

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam00169
Location:2227 → 2279

PH; PH domain

pfam06476
Location:2560 → 2617

DUF1090; Protein of unknown function (DUF1090)

cl17171
Location:2194 → 2281

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

138722445..139029401

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105531.2 → XP_038961459.1 A-kinase anchor protein 13 isoform X1

UniProtKB/TrEMBL

A0A8I5Y2J4, A0A8L2Q7A1

Related

ENSRNOP00000014802.7, ENSRNOT00000014802.8

Conserved Domains (5) summary

PHA03307
Location:545 → 837

PHA03307; transcriptional regulator ICP4; Provisional

cd00160
Location:1975 → 2169

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2509 → 2669

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2212 → 2314

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1769 → 1824

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
XM_039105543.2 → XP_038961471.1 A-kinase anchor protein 13 isoform X3

UniProtKB/TrEMBL

A0A8I5Y2J4

Conserved Domains (5) summary

PHA03307
Location:545 → 837

PHA03307; transcriptional regulator ICP4; Provisional

cd00160
Location:1975 → 2169

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2508 → 2668

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2212 → 2314

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1769 → 1824

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
XM_039105541.2 → XP_038961469.1 A-kinase anchor protein 13 isoform X2

UniProtKB/TrEMBL

A0A8I5Y2J4

Conserved Domains (5) summary

PHA03307
Location:545 → 837

PHA03307; transcriptional regulator ICP4; Provisional

cd00160
Location:1974 → 2168

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2508 → 2668

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2211 → 2313

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1769 → 1824

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
XM_063284528.1 → XP_063140598.1 A-kinase anchor protein 13 isoform X6
XM_039105548.2 → XP_038961476.1 A-kinase anchor protein 13 isoform X5

UniProtKB/TrEMBL

A0A8I5Y2J4

Conserved Domains (5) summary

PHA03307
Location:545 → 837

PHA03307; transcriptional regulator ICP4; Provisional

cd00160
Location:1973 → 2167

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2507 → 2667

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2210 → 2312

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1769 → 1824

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
XM_039105547.2 → XP_038961475.1 A-kinase anchor protein 13 isoform X4

UniProtKB/TrEMBL

A0A8I5Y2J4

Conserved Domains (5) summary

PHA03307
Location:545 → 837

PHA03307; transcriptional regulator ICP4; Provisional

cd00160
Location:1974 → 2168

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2508 → 2668

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2211 → 2313

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1769 → 1824

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
XM_063284529.1 → XP_063140599.1 A-kinase anchor protein 13 isoform X7
XM_039105554.2 → XP_038961482.1 A-kinase anchor protein 13 isoform X9

UniProtKB/TrEMBL

A0A8I5Y2J4

Related

ENSRNOP00000078206.1, ENSRNOT00000095963.2

Conserved Domains (5) summary

PHA03307
Location:545 → 837

PHA03307; transcriptional regulator ICP4; Provisional

cd00160
Location:1953 → 2147

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2487 → 2647

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2190 → 2292

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1747 → 1802

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
XM_039105549.2 → XP_038961477.1 A-kinase anchor protein 13 isoform X8

UniProtKB/TrEMBL

A0A8I5Y2J4, A0A8I6AJL6

Related

ENSRNOP00000088819.1, ENSRNOT00000101691.2

Conserved Domains (5) summary

PHA03307
Location:545 → 837

PHA03307; transcriptional regulator ICP4; Provisional

cd00160
Location:1957 → 2151

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2491 → 2651

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2194 → 2296

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1751 → 1806

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
XM_039105560.2 → XP_038961488.1 A-kinase anchor protein 13 isoform X10

UniProtKB/TrEMBL

A0A8I5XVJ8, A0A8I5Y2J4

Related

ENSRNOP00000076907.1, ENSRNOT00000108771.2

Conserved Domains (5) summary

PHA03307
Location:545 → 837

PHA03307; transcriptional regulator ICP4; Provisional

cd00160
Location:1935 → 2129

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2469 → 2629

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2172 → 2274

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1729 → 1784

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
XM_039105567.2 → XP_038961495.1 A-kinase anchor protein 13 isoform X11

UniProtKB/TrEMBL

A0A8I5Y2J4

Conserved Domains (5) summary

PHA03307
Location:545 → 837

PHA03307; transcriptional regulator ICP4; Provisional

cd00160
Location:1933 → 2127

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2467 → 2627

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2170 → 2272

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1729 → 1784

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
XM_039105573.2 → XP_038961501.1 A-kinase anchor protein 13 isoform X1

UniProtKB/TrEMBL

A0A8I5Y2J4, A0A8L2Q7A1

Related

ENSRNOP00000105310.1, ENSRNOT00000132269.1

Conserved Domains (5) summary

PHA03307
Location:545 → 837

PHA03307; transcriptional regulator ICP4; Provisional

cd00160
Location:1975 → 2169

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2509 → 2669

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2212 → 2314

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1769 → 1824

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
XM_039105585.2 → XP_038961513.1 A-kinase anchor protein 13 isoform X13

UniProtKB/TrEMBL

A0A8I5Y2J4

Conserved Domains (5) summary

PHA03307
Location:268 → 560

PHA03307; transcriptional regulator ICP4; Provisional

cd00160
Location:1698 → 1892

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2232 → 2392

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:1935 → 2037

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1492 → 1547

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
XM_039105578.2 → XP_038961506.1 A-kinase anchor protein 13 isoform X12

UniProtKB/TrEMBL

A0A8I5Y2J4

Conserved Domains (5) summary

PHA03307
Location:337 → 629

PHA03307; transcriptional regulator ICP4; Provisional

cd00160
Location:1767 → 1961

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2301 → 2461

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2004 → 2106

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1561 → 1616

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
XM_039105587.2 → XP_038961515.1 A-kinase anchor protein 13 isoform X14

Conserved Domains (4) summary

cd00160
Location:669 → 863

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13392
Location:906 → 1008

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

pfam17380
Location:1216 → 1359

DUF5401; Family of unknown function (DUF5401)

cd20878
Location:463 → 518

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
XM_063284555.1 → XP_063140625.1 A-kinase anchor protein 13 isoform X17
XM_063284552.1 → XP_063140622.1 A-kinase anchor protein 13 isoform X16
XM_063284561.1 → XP_063140631.1 A-kinase anchor protein 13 isoform X20
XM_039105588.2 → XP_038961516.1 A-kinase anchor protein 13 isoform X15

Conserved Domains (4) summary

cd00160
Location:654 → 848

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13392
Location:891 → 993

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

pfam17380
Location:1201 → 1344

DUF5401; Family of unknown function (DUF5401)

cd20878
Location:448 → 503

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
XM_039105591.2 → XP_038961519.1 A-kinase anchor protein 13 isoform X19

Conserved Domains (4) summary

cd00160
Location:613 → 807

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13392
Location:850 → 952

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

pfam17380
Location:1160 → 1303

DUF5401; Family of unknown function (DUF5401)

cd20878
Location:408 → 463

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
XM_063284557.1 → XP_063140627.1 A-kinase anchor protein 13 isoform X18
XM_063284569.1 → XP_063140639.1 A-kinase anchor protein 13 isoform X21
XM_063284572.1 → XP_063140642.1 A-kinase anchor protein 13 isoform X22