Fuca2 alpha-L-fucosidase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fuca2provided by RGD
Official Full Name: alpha-L-fucosidase 2provided by RGD
Primary source: RGD:1303053
See related: EnsemblRapid:ENSRNOG00000015551 AllianceGenome:RGD:1303053
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable alpha-L-fucosidase activity. Predicted to be involved in several processes, including fucose metabolic process; glycoside catabolic process; and regulation of entry of bacterium into host cell. Predicted to be located in extracellular space. Predicted to be active in lysosome. Orthologous to human FUCA2 (alpha-L-fucosidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 136.2), Kidney (RPKM 88.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (9706121..9720910)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (7885986..7900777)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (7658919..7673663)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-L-fucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-L-fucosidase activity	IEA Inferred from Electronic Annotation more info
enables alpha-L-fucosidase activity	ISO Inferred from Sequence Orthology more info
enables alpha-L-fucosidase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in fucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycoside catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycoside catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycoside catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of entry of bacterium into host cell	IEA Inferred from Electronic Annotation more info
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: plasma alpha-L-fucosidase

Names: alpha-L-fucoside fucohydrolase 2; fucosidase, alpha-L- 2, plasma

NP_001004218.1

EC 3.2.1.51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004218.1 → NP_001004218.1 plasma alpha-L-fucosidase precursor

See identical proteins and their annotated locations for NP_001004218.1

Status: PROVISIONAL

Source sequence(s)

BC078933

UniProtKB/Swiss-Prot

Q6AYS4

UniProtKB/TrEMBL

A6JP60

Related

ENSRNOP00000020946.5, ENSRNOT00000020946.6

Conserved Domains (3) summary

smart00812
Location:23 → 405

Alpha_L_fucos; Alpha-L-fucosidase

COG3669
Location:52 → 376

AfuC; Alpha-L-fucosidase [Carbohydrate transport and metabolism]

pfam16757
Location:368 → 456

Fucosidase_C; Alpha-L-fucosidase C-terminal domain