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Trip13 thyroid hormone receptor interactor 13 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292206, updated on 2-Nov-2024

Summary

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Official Symbol
Trip13provided by RGD
Official Full Name
thyroid hormone receptor interactor 13provided by RGD
Primary source
RGD:1308516
See related
EnsemblRapid:ENSRNOG00000015810 AllianceGenome:RGD:1308516
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including double-strand break repair; meiosis I; and negative regulation of nuclear division. Predicted to act upstream of or within germ cell development and meiosis I. Predicted to be located in male germ cell nucleus. Predicted to be active in chromosome and nucleus. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome 3. Orthologous to human TRIP13 (thyroid hormone receptor interactor 13). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 60.3), Spleen (RPKM 40.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trip13 in Genome Data Viewer
Location:
1p11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (31185700..31230638)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (29357093..29402078)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (31967980..32012923)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene tubulin polymerization promoting protein Neighboring gene zinc finger, DHHC-type containing 11 Neighboring gene uncharacterized LOC134484978 Neighboring gene bromodomain containing 9 Neighboring gene small nucleolar RNA SNORA21 Neighboring gene NKD inhibitor of WNT signaling pathway 2 Neighboring gene solute carrier family 12 member 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation. Yost S, et al. Nat Genet, 2017 Jul. PMID 28553959, Free PMC Article
  2. Mouse TRIP13/PCH2 is required for recombination and normal higher-order chromosome structure during meiosis. Roig I, et al. PLoS Genet, 2010 Aug 12. PMID 20711356, Free PMC Article
  3. Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis. Li XC, et al. PLoS Genet, 2007 Aug. PMID 17696610, Free PMC Article
  4. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
  5. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within female meiosis I ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within male meiosis I ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic recombination checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within oocyte maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in oogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in oogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in oogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within reciprocal meiotic recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in reciprocal meiotic recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in reciprocal meiotic recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within spermatid development ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synaptonemal complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptonemal complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in male germ cell nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pachytene checkpoint protein 2 homolog
Names
TR-interacting protein 13
TRIP-13
thyroid receptor-interacting protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011930.1 → NP_001011930.1  pachytene checkpoint protein 2 homolog

    See identical proteins and their annotated locations for NP_001011930.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083900
    UniProtKB/Swiss-Prot
    Q5XHZ9
    UniProtKB/TrEMBL
    A0A8L2R3S2, A6JUW1
    Related
    ENSRNOP00000021532.3, ENSRNOT00000021532.6
    Conserved Domains (1) summary
    cd19508
    Location:121 → 319
    RecA-like_Pch2-like; ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    31185700..31230638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103353.2 → XP_038959281.1  pachytene checkpoint protein 2 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5XHZ9
    UniProtKB/TrEMBL
    A0A8L2R3S2, A6JUW1
    Conserved Domains (1) summary
    cd19508
    Location:121 → 319
    RecA-like_Pch2-like; ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains

  2. XM_008758681.3 → XP_008756903.1  pachytene checkpoint protein 2 homolog isoform X1

    See identical proteins and their annotated locations for XP_008756903.1

    UniProtKB/Swiss-Prot
    Q5XHZ9
    UniProtKB/TrEMBL
    A0A8L2R3S2, A6JUW1
    Conserved Domains (1) summary
    cd19508
    Location:121 → 319
    RecA-like_Pch2-like; ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XHZ9.1 GenPept UniProtKB/Swiss-Prot:Q5XHZ9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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