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Cdt1 chromatin licensing and DNA replication factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292071, updated on 17-Aug-2024

Summary

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Official Symbol
Cdt1provided by RGD
Official Full Name
chromatin licensing and DNA replication factor 1provided by RGD
Primary source
RGD:1309211
See related
EnsemblRapid:ENSRNOG00000013970 AllianceGenome:RGD:1309211
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ris2
Summary
Predicted to enable DNA binding activity; DNA polymerase binding activity; and chromatin binding activity. Predicted to be involved in several processes, including regulation of DNA-dependent DNA replication; regulation of cell cycle phase transition; and regulation of protein localization to kinetochore. Predicted to act upstream of or within regulation of nuclear cell cycle DNA replication. Predicted to be located in kinetochore and nuclear body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 4. Orthologous to human CDT1 (chromatin licensing and DNA replication factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 44.5), Spleen (RPKM 40.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19q12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (67529249..67534195)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (50620713..50625659)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (55381565..55386511)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene cytosolic thiouridylase subunit 2 Neighboring gene piezo-type mechanosensitive ion channel component 1 Neighboring gene uncharacterized LOC103694354 Neighboring gene adenine phosphoribosyl transferase Neighboring gene galactosamine (N-acetyl)-6-sulfatase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Oncogenic potential of the DNA replication licensing protein CDT1. Arentson E, et al. Oncogene, 2002 Feb 14. PMID 11850834
  2. The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells. Cook JG, et al. J Biol Chem, 2004 Mar 5. PMID 14672932
  3. Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity. Yanagi K, et al. J Biol Chem, 2002 Oct 25. PMID 12192004
  4. Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment. Varma D, et al. Nat Cell Biol, 2012 May 13. PMID 22581055, Free PMC Article
  5. Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. Sugimoto N, et al. J Biol Chem, 2004 May 7. PMID 14993212

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA polymerase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated DNA replication initiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of nuclear cell cycle DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in response to sorbitol ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA replication factor Cdt1
Names
retroviral integration site 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106192.1 → NP_001099662.1  DNA replication factor Cdt1

    See identical proteins and their annotated locations for NP_001099662.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473972
    UniProtKB/TrEMBL
    A6IZS7, D3ZKD4
    Related
    ENSRNOP00000018923.4, ENSRNOT00000018923.7
    Conserved Domains (2) summary
    cd08674
    Location:180 → 363
    Cdt1_m; The middle winged helix fold of replication licensing factor Cdt1 binds geminin to inhibit binding of the MCM complex to origins of replication and DNA
    cd08767
    Location:426 → 548
    Cdt1_c; The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    67529249..67534195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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