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Olfm4 olfactomedin 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290409, updated on 17-Sep-2024

Summary

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Official Symbol
Olfm4provided by RGD
Official Full Name
olfactomedin 4provided by RGD
Primary source
RGD:1311708
See related
EnsemblRapid:ENSRNOG00000013280 AllianceGenome:RGD:1311708
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cadherin binding activity and structural molecule activity. Predicted to be involved in positive regulation of substrate adhesion-dependent cell spreading. Predicted to act upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling and negative regulation of immune response. Predicted to be located in several cellular components, including intercellular bridge; perinuclear region of cytoplasm; and specific granule. Predicted to be part of protein-containing complex. Orthologous to human OLFM4 (olfactomedin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 59.1), Spleen (RPKM 25.6) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Olfm4 in Genome Data Viewer
Location:
15q12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (61790889..61838773)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (55385100..55429687)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (62384263..62429450)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352947 Neighboring gene protocadherin 8 Neighboring gene ribosomal protein L14 like 1 Neighboring gene microRNA 1297

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The human neutrophil subsets defined by the presence or absence of OLFM4 both transmigrate into tissue in vivo and give rise to distinct NETs in vitro. Welin A, et al. PLoS One, 2013. PMID 23922742, Free PMC Article
  2. The glycoprotein hGC-1 binds to cadherin and lectins. Liu W, et al. Exp Cell Res, 2006 Jun 10. PMID 16566923
  3. pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1. Rosenbauer F, et al. Blood, 2004 Jun 1. PMID 14962908
  4. Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection. Liu W, et al. Proc Natl Acad Sci U S A, 2010 Jun 15. PMID 20534456, Free PMC Article
  5. Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Palmer DJ, et al. Proteomics, 2006 Apr. PMID 16502470

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of OLFM4 protects cardiomyocytes from sepsis by inhibiting apoptosis and inflammatory responses.
    Title: Knockdown of OLFM4 protects cardiomyocytes from sepsis by inhibiting apoptosis and inflammatory responses.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
  
enables structural molecule activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
NOT located_in azurophil granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
NOT located_in secretory granule ISO
Inferred from Sequence Orthology
more info
  
located_in specific granule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
olfactomedin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106052.1 → NP_001099522.1  olfactomedin-4 precursor

    See identical proteins and their annotated locations for NP_001099522.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473951
    UniProtKB/TrEMBL
    A6HU14, D3ZMI6
    Related
    ENSRNOP00000039120.3, ENSRNOT00000047572.5
    Conserved Domains (1) summary
    pfam02191
    Location:249 → 501
    OLF; Olfactomedin-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    61790889..61838773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008770863.4 → XP_008769085.1  olfactomedin-4 isoform X1

    Conserved Domains (1) summary
    pfam02191
    Location:191 → 443
    OLF; Olfactomedin-like domain

  2. XM_063274167.1 → XP_063130237.1  olfactomedin-4 isoform X2

  3. XM_039093182.2 → XP_038949110.1  olfactomedin-4 isoform X3

    Conserved Domains (1) summary
    pfam02191
    Location:58 → 310
    OLF; Olfactomedin-like domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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