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Adam28 ADAM metallopeptidase domain 28 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290344, updated on 2-Nov-2024

Summary

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Official Symbol
Adam28provided by RGD
Official Full Name
ADAM metallopeptidase domain 28provided by RGD
Primary source
RGD:727820
See related
EnsemblRapid:ENSRNOG00000014518 AllianceGenome:RGD:727820
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable immunoglobulin receptor binding activity and metalloendopeptidase activity. Predicted to be involved in proteolysis. Located in cell surface. Human ortholog(s) of this gene implicated in breast cancer; estrogen-receptor positive breast cancer; invasive ductal carcinoma; lung adenocarcinoma; and lung non-small cell carcinoma. Orthologous to human ADAM28 (ADAM metallopeptidase domain 28). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 9.8), Uterus (RPKM 7.9) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Adam28 in Genome Data Viewer
Location:
15p11
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (50184286..50250605, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (43774463..43840726, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (50356745..50425911, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribosome biogenesis regulator 1 homolog, pseudogene 13 Neighboring gene septin 2, pseudogene 1 Neighboring gene ribosomal protein L7a, pseudogene 3 Neighboring gene stanniocalcin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Selective Inhibition of ADAM28 Suppresses Lung Carcinoma Cell Growth and Metastasis. Mochizuki S, et al. Mol Cancer Ther, 2018 Nov. PMID 30190423
  2. Catalytic activity of ADAM28. Howard L, et al. FEBS Lett, 2001 Jun 1. PMID 11389903
  3. ADAM23 is a cell-surface glycoprotein expressed by central nervous system neurons. Goldsmith AP, et al. J Neurosci Res, 2004 Dec 1. PMID 15505805
  4. Baseline and decline of serum ADAM28 during chemotherapy of advanced non-small cell lung cancer: a probable predictive and prognostic factor. Lv YL, et al. Med Oncol, 2012 Dec. PMID 22354764
  5. The expression of ADAM23 and its correlation with promoter methylation in non-small-cell lung carcinoma. Hu C, et al. Int J Exp Pathol, 2011 Oct. PMID 21429053, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables immunoglobulin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 28
Names
a disintegrin and metallopeptidase domain 28
a disintegrin and metalloprotease domain 28
a disintegrin and metalloproteinase domain 28
NP_001381600.1
XP_017455117.1
XP_038949072.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394671.1 → NP_001381600.1  disintegrin and metalloproteinase domain-containing protein 28 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A8I6A4L8
    Related
    ENSRNOP00000076864.2, ENSRNOT00000095968.2
    Conserved Domains (3) summary
    smart00050
    Location:419 → 493
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:496 → 623
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:206 → 400
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

RNA

  1. NR_172143.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    50184286..50250605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093144.2 → XP_038949072.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A4L8
    Related
    ENSRNOP00000111009.1, ENSRNOT00000134510.1
    Conserved Domains (4) summary
    smart00050
    Location:419 → 493
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:496 → 623
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:206 → 400
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01562
    Location:31 → 158
    Pep_M12B_propep; Reprolysin family propeptide

  2. XM_017599628.3 → XP_017455117.1  disintegrin and metalloproteinase domain-containing protein 28 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A4L8, A6HTG5
    Conserved Domains (5) summary
    smart00050
    Location:419 → 493
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:496 → 623
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:206 → 400
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:206 → 402
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:42 → 156
    Pep_M12B_propep; Reprolysin family propeptide
Nucleotide Protein Strain
Heading Accession and Version

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