U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tlr5 toll-like receptor 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289337, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
Tlr5provided by RGD
Official Full Name
toll-like receptor 5provided by RGD
Primary source
RGD:631351
See related
EnsemblRapid:ENSRNOG00000022067 AllianceGenome:RGD:631351
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable interleukin-1 receptor binding activity and signaling receptor activity. Involved in cellular response to lipopolysaccharide; male gonad development; and positive regulation of nitric oxide biosynthetic process. Located in membrane. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in Legionnaires' disease; cystic fibrosis; cystitis; melioidosis; and systemic lupus erythematosus. Orthologous to human TLR5 (toll like receptor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 54.3), Lung (RPKM 17.3) and 8 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tlr5 in Genome Data Viewer
Location:
13q26
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (97166430..97190642)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (94634778..94658992)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (101364784..101385764)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD113/SNORD114 family Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1, pseudogene 19 Neighboring gene dispatched RND transporter family member 1 Neighboring gene uncharacterized LOC108352652

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Bacterial flagellin triggers cardiac innate immune responses and acute contractile dysfunction. Rolli J, et al. PLoS One, 2010 Sep 13. PMID 20856884, Free PMC Article
  2. Effects of mannoprotein E1 in liquid diet on inflammatory response and TLR5 expression in the gut of rats infected by Salmonella typhimurium. Posadas SJ, et al. BMC Gastroenterol, 2010 Jun 8. PMID 20529359, Free PMC Article
  3. Toll-like receptor signaling stimulates cell cycle entry and progression in fibroblasts. Hasan UA, et al. J Biol Chem, 2005 May 27. PMID 15788393
  4. Gene expression of Toll-like receptors and associated molecules induced by inflammatory stimuli in the primary alveolar macrophage. Oshikawa K, et al. Biochem Biophys Res Commun, 2003 Jun 6. PMID 12763043
  5. Exosomal microRNA-150-5p from bone marrow mesenchymal stromal cells mitigates cerebral ischemia/reperfusion injury via targeting toll-like receptor 5. Li X, et al. Bioengineered, 2022 Feb. PMID 34898357, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exosomal microRNA-150-5p from bone marrow mesenchymal stromal cells mitigates cerebral ischemia/reperfusion injury via targeting toll-like receptor 5.
    Title: Exosomal microRNA-150-5p from bone marrow mesenchymal stromal cells mitigates cerebral ischemia/reperfusion injury via targeting toll-like receptor 5.
  2. Toll-like receptor 5 deficiency diminishes doxorubicin-induced acute cardiotoxicity in mice.
    Title: Toll-like receptor 5 deficiency diminishes doxorubicin-induced acute cardiotoxicity in mice.
  3. Cross-Talk of Toll-Like Receptor 5 and Mu-Opioid Receptor Attenuates Chronic Constriction Injury-Induced Mechanical Hyperalgesia through a Protein Kinase C Alpha-Dependent Signaling.
    Title: Cross-Talk of Toll-Like Receptor 5 and Mu-Opioid Receptor Attenuates Chronic Constriction Injury-Induced Mechanical Hyperalgesia through a Protein Kinase C Alpha-Dependent Signaling.
  4. Results suggest that TLR5 is a potential target gene of miR-150. TLR5 seems to negatively regulate miR-150 in vitro.
    Title: MiR-150 alleviates neuropathic pain via inhibiting toll-like receptor 5.
  5. These results suggest that HMGB1-modulated TLR5 signaling is responsible for pain hypersensitivity.
    Title: HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia.
  6. aortic angiogenesis is preceded by an immune reaction with overexpression of Toll-like receptors (TLRs) and TLR-inducible genes.
    Title: Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.
  7. study found glucose up-regulates TLR-5 in islet cells, and that TLR-5 activation reduces insulin secretion, increases the level of heat-shock protein and increases MHC class I transport for presentation.
    Title: Glucose activation of islets of Langerhans up-regulates Toll-like receptor 5: possible mechanism of protection.
  8. toll-like receptors and nucleotide-binding oligomerization domain 2 combinations are contributors to the signaling cascades resulting in purinergic microglial activation
    Title: Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression.
  9. PSCs expressed a variety of TLRs and responded to TLR ligands, leading to the activation of signaling pathways and proinflammatory responses.
    Title: Pancreatic stellate cells express Toll-like receptors.
  10. data provide evidence for a nonimmune and cell autonomous role of Toll-like receptor 5 (TLR5) signaling, whereby TLR5 stimulation provides a positive signal for cell division
    Title: Toll-like receptor signaling stimulates cell cycle entry and progression in fibroblasts.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables interleukin-1 receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables pattern recognition receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in male gonad development IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
  
involved_in toll-like receptor 5 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
toll-like receptor 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145828.1 → NP_001139300.1  toll-like receptor 5

    See identical proteins and their annotated locations for NP_001139300.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473985
    UniProtKB/TrEMBL
    A6JGM7, G3V6F8
    Conserved Domains (6) summary
    TIGR00864
    Location:567 → 645
    PCC; polycystin cation channel protein
    PLN00113
    Location:108 → 384
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:314 → 578
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:302 → 325
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:706 → 856
    TIR; TIR domain
    pfam13855
    Location:326 → 384
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    97166430..97190642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272173.1 → XP_063128243.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    A6JGM7, G3V6F8
    Related
    ENSRNOP00000092561.1, ENSRNOT00000109851.2

  2. XM_039090570.2 → XP_038946498.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    A6JGM7, G3V6F8
    Related
    ENSRNOP00000107039.1, ENSRNOT00000127807.1
    Conserved Domains (6) summary
    TIGR00864
    Location:567 → 645
    PCC; polycystin cation channel protein
    PLN00113
    Location:108 → 384
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:314 → 578
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:302 → 325
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:706 → 856
    TIR; TIR domain
    pfam13855
    Location:326 → 384
    LRR_8; Leucine rich repeat

  3. XM_039090569.2 → XP_038946497.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    A6JGM7, G3V6F8
    Related
    ENSRNOP00000102645.1, ENSRNOT00000145129.1
    Conserved Domains (6) summary
    TIGR00864
    Location:567 → 645
    PCC; polycystin cation channel protein
    PLN00113
    Location:108 → 384
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:314 → 578
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:302 → 325
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:706 → 856
    TIR; TIR domain
    pfam13855
    Location:326 → 384
    LRR_8; Leucine rich repeat

  4. XM_039090571.2 → XP_038946499.1  toll-like receptor 5 isoform X2

    UniProtKB/TrEMBL
    C0LP03
    Related
    ENSRNOP00000086526.1, ENSRNOT00000107238.2
    Conserved Domains (6) summary
    TIGR00864
    Location:555 → 633
    PCC; polycystin cation channel protein
    PLN00113
    Location:96 → 372
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:302 → 566
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:290 → 313
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:694 → 844
    TIR; TIR domain
    pfam13855
    Location:314 → 372
    LRR_8; Leucine rich repeat

  5. XM_039090568.2 → XP_038946496.1  toll-like receptor 5 isoform X1

    UniProtKB/TrEMBL
    A6JGM7, G3V6F8
    Related
    ENSRNOP00000107919.1, ENSRNOT00000136113.1
    Conserved Domains (6) summary
    TIGR00864
    Location:567 → 645
    PCC; polycystin cation channel protein
    PLN00113
    Location:108 → 384
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:314 → 578
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:302 → 325
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:706 → 856
    TIR; TIR domain
    pfam13855
    Location:326 → 384
    LRR_8; Leucine rich repeat

  6. XM_039090572.2 → XP_038946500.1  toll-like receptor 5 isoform X2

    UniProtKB/TrEMBL
    C0LP03
    Conserved Domains (6) summary
    TIGR00864
    Location:555 → 633
    PCC; polycystin cation channel protein
    PLN00113
    Location:96 → 372
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    COG4886
    Location:302 → 566
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:290 → 313
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01582
    Location:694 → 844
    TIR; TIR domain
    pfam13855
    Location:314 → 372
    LRR_8; Leucine rich repeat

RNA

  1. XR_005492227.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools