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Mcm7 minichromosome maintenance complex component 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288532, updated on 2-Nov-2024

Summary

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Official Symbol
Mcm7provided by RGD
Official Full Name
minichromosome maintenance complex component 7provided by RGD
Primary source
RGD:1303018
See related
EnsemblRapid:ENSRNOG00000001349 AllianceGenome:RGD:1303018
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Involved in cellular response to epidermal growth factor stimulus and response to xenobiotic stimulus. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of CMG complex and MCM complex. Predicted to be active in nucleus. Used to study hepatocellular carcinoma. Biomarker of hepatocellular carcinoma and hyperthyroidism. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MCM7 (minichromosome maintenance complex component 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 521.1), Spleen (RPKM 289.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mcm7 in Genome Data Viewer
Location:
12q11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (22155921..22163320, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (17042207..17049470, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (19306615..19313877, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 21 Neighboring gene zinc finger protein 3 Neighboring gene COP9 signalosome subunit 6 Neighboring gene microRNA 106b Neighboring gene microRNA 25 Neighboring gene microRNA 93 Neighboring gene adaptor related protein complex 4 subunit mu 1 Neighboring gene TATA-box binding protein associated factor 6 Neighboring gene canopy FGF signaling regulator 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Atorvastatin inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells. Bruemmer D, et al. Eur J Pharmacol, 2003 Feb 21. PMID 12591091
  2. Peroxisome proliferator-activated receptor gamma inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells. Bruemmer D, et al. Mol Endocrinol, 2003 Jun. PMID 12677008
  3. MCM7 expression is altered in rat after spinal cord injury. Chen J, et al. J Mol Neurosci, 2013 Sep. PMID 23526403
  4. Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays. Grützmann R, et al. Neoplasia, 2004 Sep-Oct. PMID 15548371, Free PMC Article
  5. Identification, molecular cloning, and cellular distribution of the rat homolog of minichromosome maintenance protein 7 (MCM7) in the rat testis. Com E, et al. Mol Reprod Dev, 2006 Jul. PMID 16557521

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MCM7 expression and distribution change in injured spinal cord tissue.
    Title: MCM7 expression is altered in rat after spinal cord injury.
  2. The study describes the cellular distribution of Minichromosome Maintenance Protein 7, MCM7 transcripts and protein, and their testicular ontogenetic expression.
    Title: Identification, molecular cloning, and cellular distribution of the rat homolog of minichromosome maintenance protein 7 (MCM7) in the rat testis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC93853

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding TAS
Traceable Author Statement
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA TAS
Traceable Author Statement
more info
 PubMed 
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
contributes_to DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication TAS
Traceable Author Statement
more info
 PubMed 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA strand elongation involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA unwinding involved in DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA unwinding involved in DNA replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to epidermal growth factor stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of CMG complex ISO
Inferred from Sequence Orthology
more info
  
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MCM complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA replication licensing factor MCM7
Names
minichromosome maintenance deficient 7
minichromosome maintenance protein 7
NP_001004203.3
XP_006249067.1
XP_006249068.1
XP_063127213.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004203.3 → NP_001004203.3  DNA replication licensing factor MCM7

    See identical proteins and their annotated locations for NP_001004203.3

    Status: PROVISIONAL

    Source sequence(s)
    BC078973
    UniProtKB/TrEMBL
    A0A8I5Y509, A6KSS8, Q1PS21, Q6AYN8
    Related
    ENSRNOP00000076814.1, ENSRNOT00000105826.2
    Conserved Domains (3) summary
    smart00350
    Location:145 → 641
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:12 → 165
    MCM_N; MCM N-terminal domain
    cl21455
    Location:376 → 515
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    22155921..22163320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249006.5 → XP_006249068.1  DNA replication licensing factor MCM7 isoform X2

    See identical proteins and their annotated locations for XP_006249068.1

    UniProtKB/TrEMBL
    A6KST0, F7F0X7
    Conserved Domains (1) summary
    smart00350
    Location:38 → 534
    MCM; minichromosome maintenance proteins

  2. XM_006249005.5 → XP_006249067.1  DNA replication licensing factor MCM7 isoform X2

    See identical proteins and their annotated locations for XP_006249067.1

    UniProtKB/TrEMBL
    A6KST0, F7F0X7
    Conserved Domains (1) summary
    smart00350
    Location:38 → 534
    MCM; minichromosome maintenance proteins

  3. XM_063271143.1 → XP_063127213.1  DNA replication licensing factor MCM7 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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