Poglut1 protein O-glucosyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Poglut1provided by RGD
Official Full Name: protein O-glucosyltransferase 1provided by RGD
Primary source: RGD:1306248
See related: EnsemblRapid:ENSRNOG00000003014 AllianceGenome:RGD:1306248
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ktelc1; RGD1306248
Summary: Predicted to enable UDP-glucosyltransferase activity and UDP-xylosyltransferase activity. Predicted to be involved in several processes, including positive regulation of Notch signaling pathway; protein O-linked glycosylation via serine; and regulation of gastrulation. Predicted to act upstream of or within several processes, including paraxial mesoderm development; regulation of Notch signaling pathway; and somitogenesis. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endomembrane system. Human ortholog(s) of this gene implicated in Dowling-Degos disease and autosomal recessive limb-girdle muscular dystrophy type 2Z. Orthologous to human POGLUT1 (protein O-glucosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 128.2), Brain (RPKM 117.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (75704119..75731964)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (62198600..62226446)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (64761493..64788210)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

RH141283 (e-PCR)
- UniSTS:223279

RH143536 (e-PCR)
- UniSTS:232782

Poglut1 (e-PCR), detects polymorphism
- UniSTS:547993

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables EGF-domain serine glucosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables EGF-domain serine xylosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables UDP-glucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-glucosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables UDP-glucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables UDP-glucosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables UDP-xylosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-xylosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables UDP-xylosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables UDP-xylosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glucosyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axial mesoderm development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axial mesoderm development	ISO Inferred from Sequence Orthology more info
involved_in circulatory system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within circulatory system development	ISO Inferred from Sequence Orthology more info
involved_in gastrulation	IEA Inferred from Electronic Annotation more info
involved_in muscle tissue development	IEA Inferred from Electronic Annotation more info
involved_in muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in muscle tissue development	ISS Inferred from Sequence or Structural Similarity more info
involved_in paraxial mesoderm development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within paraxial mesoderm development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein O-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein O-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked glycosylation via serine	IEA Inferred from Electronic Annotation more info
involved_in protein O-linked glycosylation via serine	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked glycosylation via serine	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of gastrulation	IEA Inferred from Electronic Annotation more info
involved_in regulation of gastrulation	ISO Inferred from Sequence Orthology more info
involved_in regulation of gastrulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in somitogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somitogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein O-glucosyltransferase 1

Names: KTEL (Lys-Tyr-Glu-Leu) containing 1; O-glucosyltransferase Rumi homolog; protein O-xylosyltransferase

NP_001094122.1

EC 2.4.1.376

EC 2.4.2.63

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.