U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tspoap1 TSPO associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287609, updated on 10-Jul-2024

Summary

Go to the top of the page Help
Official Symbol
Tspoap1provided by RGD
Official Full Name
TSPO associated protein 1provided by RGD
Primary source
RGD:708563
See related
EnsemblRapid:ENSRNOG00000007957 AllianceGenome:RGD:708563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bzrap1; PRAX-1; RIM-BP1
Summary
Predicted to enable benzodiazepine receptor binding activity and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Predicted to be involved in regulation of presynaptic cytosolic calcium ion concentration. Located in mitochondrion. Orthologous to human TSPOAP1 (TSPO associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 128.8), Thymus (RPKM 22.9) and 4 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tspoap1 in Genome Data Viewer
Location:
10q26
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (73053414..73083640)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (72554220..72586402)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (75053956..75079615)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 43 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134480847 Neighboring gene SPT4 homolog, DSIF elongation factor subunit Neighboring gene microRNA 142 Neighboring gene myeloperoxidase Neighboring gene lactoperoxidase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Expression profile and up-regulation of PRAX-1 mRNA by antidepressant treatment in the rat brain. Chardenot P, et al. Mol Pharmacol, 2002 Dec. PMID 12435798
  2. Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor. Galiègue S, et al. J Biol Chem, 1999 Jan 29. PMID 9915832
  3. RIM-BPs Mediate Tight Coupling of Action Potentials to Ca(2+)-Triggered Neurotransmitter Release. Acuna C, et al. Neuron, 2015 Sep 23. PMID 26402606
  4. The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins. Wang Y, et al. J Biol Chem, 2000 Jun 30. PMID 10748113
  5. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables benzodiazepine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables benzodiazepine receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables benzodiazepine receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables benzodiazepine receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in neuromuscular synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neurotransmitter secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of presynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in calyx of Held IEA
Inferred from Electronic Annotation
more info
  
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
peripheral-type benzodiazepine receptor-associated protein 1
Names
RIM binding protein 1
RIMS-binding protein 1
benzodiazapine receptor (peripheral) associated protein 1
benzodiazapine receptor associated protein 1
benzodiazepine receptor (peripheral) associated protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419563.1 → NP_001406492.1  peripheral-type benzodiazepine receptor-associated protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q9JIQ9, Q9JIR0
    UniProtKB/TrEMBL
    A0A8I6AW95, A6HHV4
    Related
    ENSRNOP00000097355.1, ENSRNOT00000103171.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    73053414..73083640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597680.3 → XP_017453169.1  peripheral-type benzodiazepine receptor-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9JIQ9, Q9JIR0

  2. XM_017597684.3 → XP_017453173.1  peripheral-type benzodiazepine receptor-associated protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q9JIQ9, Q9JIR0
    Conserved Domains (9) summary
    cd12012
    Location:1619 → 1680
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:1777 → 1836
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:653 → 713
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:881 → 943
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:788 → 866
    fn3; Fibronectin type III domain
    pfam08614
    Location:37 → 183
    ATG16; Autophagy protein 16 (ATG16)
    pfam12718
    Location:346 → 503
    Tropomyosin_1; Tropomyosin like
    cl02488
    Location:332 → 518
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl23720
    Location:427 → 519
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  3. XM_017597682.3 → XP_017453171.1  peripheral-type benzodiazepine receptor-associated protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9JIQ9, Q9JIR0

  4. XM_213427.10 → XP_213427.5  peripheral-type benzodiazepine receptor-associated protein 1 isoform X4

    See identical proteins and their annotated locations for XP_213427.5

    UniProtKB/Swiss-Prot
    Q9JIQ9, Q9JIR0
    UniProtKB/TrEMBL
    A0A8I6AW95, A6HHV4
    Conserved Domains (9) summary
    cd12012
    Location:1619 → 1680
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:1759 → 1818
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:653 → 713
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:881 → 943
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:788 → 866
    fn3; Fibronectin type III domain
    pfam08614
    Location:37 → 183
    ATG16; Autophagy protein 16 (ATG16)
    pfam12718
    Location:346 → 503
    Tropomyosin_1; Tropomyosin like
    cl02488
    Location:332 → 518
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl23720
    Location:427 → 519
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  5. XM_017597685.3 → XP_017453174.1  peripheral-type benzodiazepine receptor-associated protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZZW2

  6. XM_017597686.3 → XP_017453175.1  peripheral-type benzodiazepine receptor-associated protein 1 isoform X6

    Conserved Domains (6) summary
    cd12012
    Location:1183 → 1244
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:1341 → 1400
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:217 → 277
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:445 → 507
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:352 → 430
    fn3; Fibronectin type III domain
    cl23720
    Location:2 → 88
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIR0.2 GenPept UniProtKB/Swiss-Prot:Q9JIR0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools