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Taok1 TAO kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 286993, updated on 2-Nov-2024

Summary

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Official Symbol
Taok1provided by RGD
Official Full Name
TAO kinase 1provided by RGD
Primary source
RGD:708455
See related
EnsemblRapid:ENSRNOG00000015692 AllianceGenome:RGD:708455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables several functions, including myosin V binding activity; protein kinase binding activity; and protein serine/threonine kinase activator activity. Involved in protein autophosphorylation; regulation of actin cytoskeleton organization; and regulation of microtubule cytoskeleton organization. Predicted to be located in microtubule cytoskeleton and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Orthologous to human TAOK1 (TAO kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 423.5), Adrenal (RPKM 405.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Taok1 in Genome Data Viewer
Location:
10q24
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (62871198..62989049, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (62373072..62465295, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (62542870..62630341)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene tumor protein p53 inducible protein 13 Neighboring gene abhydrolase domain containing 15 Neighboring gene cytochrome c oxidase subunit 7C, mitochondrial-like Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TAOK1-mediated regulation of the YAP/TEAD pathway as a potential therapeutic target in heart failure. Zhou J, et al. PLoS One, 2024. PMID 39121041, Free PMC Article
  2. Thousand and one kinase 1 protects MCAO-induced cerebral ischemic stroke in rats by decreasing apoptosis and pro-inflammatory factors. Li J, et al. Biosci Rep, 2019 Oct 30. PMID 31652447, Free PMC Article
  3. The miR-183/Taok1 target pair is implicated in cochlear responses to acoustic trauma. Patel M, et al. PLoS One, 2013. PMID 23472202, Free PMC Article
  4. Human TAO kinase 1 induces apoptosis in SH-SY5Y cells. Wu MF, et al. Cell Biol Int, 2008 Jan. PMID 17900936
  5. Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1. Zihni C, et al. J Biol Chem, 2006 Mar 17. PMID 16407310

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TAOK1-mediated regulation of the YAP/TEAD pathway as a potential therapeutic target in heart failure.
    Title: TAOK1-mediated regulation of the YAP/TEAD pathway as a potential therapeutic target in heart failure.
  2. Thousand and one kinase 1 protects MCAO-induced cerebral ischemic stroke in rats by decreasing apoptosis and pro-inflammatory factors.
    Title: Thousand and one kinase 1 protects MCAO-induced cerebral ischemic stroke in rats by decreasing apoptosis and pro-inflammatory factors.
  3. Inhibition of miR-183 in cochlear organotypic culture leads to upregulation of Taok1. Exposure to noise caused a significant upregulation of Taok1.
    Title: The miR-183/Taok1 target pair is implicated in cochlear responses to acoustic trauma.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables myosin V binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system neuron development IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system neuron development ISO
Inferred from Sequence Orthology
more info
  
involved_in central nervous system neuron development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
  
involved_in execution phase of apoptosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron cellular homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress-activated MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress-activated MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase TAO1
Names
thousand and one amino acid protein 1
NP_775449.2
XP_038941256.1
XP_038941257.1
XP_038941258.1
XP_038941260.1
XP_063124576.1
XP_063124577.1
XP_063124578.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173327.3 → NP_775449.2  serine/threonine-protein kinase TAO1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    O88664
    UniProtKB/TrEMBL
    A6HGY8
    Conserved Domains (2) summary
    COG0419
    Location:442 → 877
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06635
    Location:2 → 318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    62871198..62989049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268508.1 → XP_063124578.1  serine/threonine-protein kinase TAO1 isoform X1

    UniProtKB/TrEMBL
    A6HGY8

  2. XM_063268507.1 → XP_063124577.1  serine/threonine-protein kinase TAO1 isoform X1

    UniProtKB/TrEMBL
    A6HGY8

  3. XM_039085332.2 → XP_038941260.1  serine/threonine-protein kinase TAO1 isoform X1

    UniProtKB/Swiss-Prot
    O88664
    UniProtKB/TrEMBL
    A6HGY8
    Conserved Domains (2) summary
    COG0419
    Location:442 → 877
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06635
    Location:2 → 318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

  4. XM_039085330.2 → XP_038941258.1  serine/threonine-protein kinase TAO1 isoform X1

    UniProtKB/Swiss-Prot
    O88664
    UniProtKB/TrEMBL
    A6HGY8
    Related
    ENSRNOP00000021368.8, ENSRNOT00000021368.8
    Conserved Domains (2) summary
    COG0419
    Location:442 → 877
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06635
    Location:2 → 318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

  5. XM_039085328.2 → XP_038941256.1  serine/threonine-protein kinase TAO1 isoform X1

    UniProtKB/Swiss-Prot
    O88664
    UniProtKB/TrEMBL
    A6HGY8
    Conserved Domains (2) summary
    COG0419
    Location:442 → 877
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06635
    Location:2 → 318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

  6. XM_063268506.1 → XP_063124576.1  serine/threonine-protein kinase TAO1 isoform X1

    UniProtKB/TrEMBL
    A6HGY8

  7. XM_039085329.2 → XP_038941257.1  serine/threonine-protein kinase TAO1 isoform X1

    UniProtKB/Swiss-Prot
    O88664
    UniProtKB/TrEMBL
    A6HGY8
    Conserved Domains (2) summary
    COG0419
    Location:442 → 877
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06635
    Location:2 → 318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88664.1 GenPept UniProtKB/Swiss-Prot:O88664

Gene LinkOut

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