U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PPARG peroxisome proliferator activated receptor gamma [ Bos taurus (domestic cattle) ]

Gene ID: 281993, updated on 4-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
PPARGprovided by VGNC
Official Full Name
peroxisome proliferator activated receptor gammaprovided by VGNC
Primary source
VGNC:VGNC:33183
See related
BGD:BT12230
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PPARG in Genome Data Viewer
Location:
chromosome: 22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (56710574..56775806, complement)

Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene PPARG-TSEN2 Neighboring gene MKRN2 opposite strand Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene microRNA mir-2373 Neighboring gene synapsin II Neighboring gene TIMP metallopeptidase inhibitor 4

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterisation of bovine peroxisome proliferator-activated receptors gamma 1 and gamma 2: genetic mapping and differential expression of the two isoforms. Sundvold H, et al. Biochem Biophys Res Commun, 1997 Oct 29. PMID 9367859
  2. mTORC2 Regulates Lipogenic Gene Expression through PPARγ to Control Lipid Synthesis in Bovine Mammary Epithelial Cells. Guo Z, et al. Biomed Res Int, 2019. PMID 31223619, Free PMC Article
  3. Gene network and pathway analysis of bovine mammary tissue challenged with Streptococcus uberis reveals induction of cell proliferation and inhibition of PPARgamma signaling as potential mechanism for the negative relationships between immune response and lipid metabolism. Moyes KM, et al. BMC Genomics, 2009 Nov 19. PMID 19925655, Free PMC Article
  4. Two Novel SNPs of PPARγ Significantly Affect Weaning Growth Traits of Nanyang Cattle. Huang J, et al. Anim Biotechnol, 2018 Jan 2. PMID 28481711
  5. An Asp7Gly substitution in PPARG is associated with decreased transcriptional activation activity. Hua L, et al. PLoS One, 2014. PMID 24466299, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myostatin site-directed mutation and simultaneous PPARgamma site-directed knockin in bovine genome.
    Title: Myostatin site-directed mutation and simultaneous PPARγ site-directed knockin in bovine genome.
  2. Bovine Stearoyl-CoA Desaturase 1 Promotes Adipogenesis by Activating the PPARgamma Receptor.
    Title: Bovine Stearoyl-CoA Desaturase 1 Promotes Adipogenesis by Activating the PPARγ Receptor.
  3. mTORC2 plays a critical role in regulating lipogenic gene expression, lipid synthesis, and secretion in bovine mammary epithelial cells, and this process probably is through PPARgamma.
    Title: mTORC2 Regulates Lipogenic Gene Expression through PPARγ to Control Lipid Synthesis in Bovine Mammary Epithelial Cells.
  4. This study shows that bta-miR-130a and bta-miR-130b play similar roles in the regulation of adipocyte differentiation in beef muscles by targeting the 3'UTR of PPARG and CYP2U1.
    Title: Bta-miR-130a/b regulates preadipocyte differentiation by targeting PPARG and CYP2U1 in beef cattle.
  5. Results found that PPAR-gamma expression is regulated by miR-454 in bovine mammary epithelial cells (BMECs). miR-454 directly targets the 3'UTR of PPAR-gamma to regulate triglyceride synthesis in BMECs.
    Title: miR-454 regulates triglyceride synthesis in bovine mammary epithelial cells by targeting PPAR-γ.
  6. Three novel SNPs of the bovine PPARgamma gene were identified in 514 individuals from six Chinese cattle breeds: SNP1 (AC_000179.1 g.57386668 C > G) in intron 2 and SNP2 (AC_000179.1 g.57431964 C > T) and SNP3 (AC_000179.1 g.57431994 T > C) in exon 7.
    Title: Two Novel SNPs of PPARγ Significantly Affect Weaning Growth Traits of Nanyang Cattle.
  7. These results indicated that docosahexaenoic acid may attenuate lipopolysaccharide-stimulated inflammatory response in bovine mammary epithelial cells by suppressing NF-kappaB activation through a mechanism partly dependent on PPARgamma activation.
    Title: Docosahexaenoic acid attenuates LPS-stimulated inflammatory response by regulating the PPARγ/NF-κB pathways in primary bovine mammary epithelial cells.
  8. PPARgamma is a positive regulator of milk fat synthesis in dairy cow mammary epithelial cells.
    Title: Regulation of peroxisome proliferator-activated receptor gamma on milk fat synthesis in dairy cow mammary epithelial cells.
  9. An Asp7Gly substitution in PPARG is associated with adiposity.
    Title: An Asp7Gly substitution in PPARG is associated with decreased transcriptional activation activity.
  10. upregulation of PPARgamma was observed in the backfat tissue of Lilu cattle with increasing age
    Title: Gene expression profiling of SIRT1, FoxO1, and PPARγ in backfat tissues and subcutaneous adipocytes of Lilu bulls.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Readthrough PPARG-TSEN2

Readthrough gene: PPARG-TSEN2, Included gene: TSEN2

Homology

Clone Names

  • MGC139055

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
peroxisome proliferator-activated receptor gamma
Names
PPAR-gamma
nuclear receptor subfamily 1 group C member 3
peroxisome proliferative activated receptor, gamma
peroxisome proliferator activated receptor gamma 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181024.2 → NP_851367.1  peroxisome proliferator-activated receptor gamma

    See identical proteins and their annotated locations for NP_851367.1

    Status: PROVISIONAL

    Source sequence(s)
    Y12420
    UniProtKB/Swiss-Prot
    O18971, Q1LZB7, Q8HY47
    Conserved Domains (3) summary
    cd06932
    Location:237 → 504
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:138 → 221
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:31 → 108
    PPARgamma_N; PPAR gamma N-terminal region

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    56710574..56775806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18971.1 GenPept UniProtKB/Swiss-Prot:O18971

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.