PDE6G phosphodiesterase 6G [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PDE6Gprovided by VGNC
Official Full Name: phosphodiesterase 6Gprovided by VGNC
Primary source: VGNC:VGNC:32683
See related: BGD:BT26787; Ensembl:ENSBTAG00000000354
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	19	NC_037346.1 (51157214..51160605)

Chromosome 19 - NC_037346.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analysis of the Rod PDE6 holoenzyme (subunit composition, alphabetagammagamma) reveals the mechanism of visual excitation
Title: The molecular architecture of photoreceptor phosphodiesterase 6 (PDE6) with activated G protein elucidates the mechanism of visual excitation.
a structural basis for interpreting how mutations in rod PDE6 subunits can lead to retinal diseases, is discussed.
Title: Allosteric Regulation of Rod Photoreceptor Phosphodiesterase 6 (PDE6) Elucidated by Chemical Cross-Linking and Quantitative Mass Spectrometry.
physiological differences between rod and cone photoreceptor light responsiveness can be partially ascribed to ancient, highly conserved amino acid differences in the N-terminal regions of Pgamma isoforms, demonstrating for the first time a functional role for this region of Pgamma in the differential activation of rod and cone PDE6 by transducin.
Title: The N termini of the inhibitory γ-subunits of phosphodiesterase-6 (PDE6) from rod and cone photoreceptors differentially regulate transducin-mediated PDE6 activation.
The approximately 11 A map revealed previously unseen features of PDE6, and each domain was readily fit with high resolution structures.
Title: Domain organization and conformational plasticity of the G protein effector, PDE6.
The 3D structure of the PDE6alphabetagamma complex was determined up to 18 A resolution from single-particle projections and was interpreted by model building to identify the probable location of isoprenylation, PDE6gamma subunits, and catalytic site
Title: Structural characterization of the rod cGMP phosphodiesterase 6.
Transducin activation of PDE6 appears to require interaction with both the C terminus and other regions of Pgamma to effectively relieve its inhibitory constraint.
Title: Structural requirements of the photoreceptor phosphodiesterase gamma-subunit for inhibition of rod PDE6 holoenzyme and for its activation by transducin.
although Pgamma-mediated regulation plays the dominant role in visual excitation, the direct, inter-domain allosteric regulation may play a feedback role in light adaptational processes during phototransduction
Title: Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.
Structural analysis of cGMP phosphodiesterase 6 alpha, beta and gamma interactions
Title: Three-dimensional structure of non-activated cGMP phosphodiesterase 6 and comparison of its image with those of activated forms.
the unique Palphabeta heterodimer contributes to the sophisticated regulation in visual transduction through interaction with Pgamma
Title: Asymmetric interaction between rod cyclic GMP phosphodiesterase gamma subunits and alphabeta subunits.
The Pgamma N-terminal Val16-Phe30 region was found to interact with the Palphabeta GAFa domain, whereas its C terminus (Phe73-Ile87) interacted with the Palphabeta catalytic domain.
Title: The inhibitory gamma subunit of the rod cGMP phosphodiesterase binds the catalytic subunits in an extended linear structure.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables cGMP binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in visual perception	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in photoreceptor outer segment membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Names: GMP-PDE gamma; phosphodiesterase 6G, cGMP-specific, rod, gamma; phosphodiesterase, cyclic GMP (rod receptor), gamma polypeptide

NP_776846.1

EC 3.1.4.35

XP_010814750.1

EC 3.1.4.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174421.2 → NP_776846.1 retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

See identical proteins and their annotated locations for NP_776846.1

Status: PROVISIONAL

Source sequence(s)

X04270

UniProtKB/Swiss-Prot

P04972

Related

ENSBTAP00000000459.1, ENSBTAT00000000459.3

Conserved Domains (1) summary

pfam04868
Location:5 → 87

PDE6_gamma; Retinal cGMP phosphodiesterase, gamma subunit

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

Range

51157214..51160605

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_010816448.4 → XP_010814750.1 retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X1

See identical proteins and their annotated locations for XP_010814750.1

UniProtKB/Swiss-Prot

P04972

Conserved Domains (1) summary

pfam04868
Location:5 → 87

PDE6_gamma; Retinal cGMP phosphodiesterase, gamma subunit