U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GNAI1 G protein subunit alpha i1 [ Bos taurus (domestic cattle) ]

Gene ID: 281790, updated on 4-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
GNAI1provided by VGNC
Official Full Name
G protein subunit alpha i1provided by VGNC
Primary source
VGNC:VGNC:29449
See related
BGD:BT11073; Ensembl:ENSBTAG00000002714
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
HG1B
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GNAI1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (40955829..41061583, complement)

Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha transducin 3 Neighboring gene cullin-1-like Neighboring gene uncharacterized LOC100296900 Neighboring gene transcription factor BTF3-like Neighboring gene membrane associated guanylate kinase, WW and PDZ domain containing 2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Molecular cloning and characterization of cDNA encoding the GTP-binding protein alpha i and identification of a related protein, alpha h. Michel T, et al. Proc Natl Acad Sci U S A, 1986 Oct. PMID 3094012, Free PMC Article
  2. Primary structure of the alpha-subunit of bovine adenylate cyclase-inhibiting G-protein deduced from the cDNA sequence. Nukada T, et al. FEBS Lett, 1986 Mar 3. PMID 2419165
  3. NMR analysis of G-protein betagamma subunit complexes reveals a dynamic G(alpha)-Gbetagamma subunit interface and multiple protein recognition modes. Smrcka AV, et al. Proc Natl Acad Sci U S A, 2010 Jan 12. PMID 20018744, Free PMC Article
  4. Synteny mapping of five human chromosome 7 genes on bovine chromosomes 4 and 21. Antoniou E, et al. Cytogenet Cell Genet, 1999. PMID 10343125
  5. The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro. Parnell SC, et al. Biochem Biophys Res Commun, 1998 Oct 20. PMID 9792824

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC128528

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled serotonin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of heterotrimeric G-protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
guanine nucleotide-binding protein G(i) subunit alpha-1
Names
adenylate cyclase-inhibiting G alpha protein
guanine nucleotide-binding protein G(i), alpha-1 subunit
heterotrimeric guanine nucleotide-binding protein 1B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174324.2 → NP_776749.1  guanine nucleotide-binding protein G(i) subunit alpha-1

    See identical proteins and their annotated locations for NP_776749.1

    Status: PROVISIONAL

    Source sequence(s)
    X03642
    UniProtKB/Swiss-Prot
    P63097, Q2KJC0
    UniProtKB/TrEMBL
    A0AAA9T3M3
    Related
    ENSBTAP00000090292.1, ENSBTAT00000134892.1
    Conserved Domains (1) summary
    cd00066
    Location:34 → 348
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    40955829..41061583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005205328.5 → XP_005205385.1  guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1

    UniProtKB/TrEMBL
    A0AAF6YJV2
    Related
    ENSBTAP00000003515.5, ENSBTAT00000003515.6
    Conserved Domains (2) summary
    cd00066
    Location:97 → 411
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:77 → 415
    G_alpha; G protein alpha subunit

  2. XM_015468832.3 → XP_015324318.1  guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X2

    UniProtKB/Swiss-Prot
    P63097, Q2KJC0
    UniProtKB/TrEMBL
    A0AAA9T3M3
    Conserved Domains (1) summary
    cd00066
    Location:34 → 348
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63097.2 GenPept UniProtKB/Swiss-Prot:P63097

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.