PDYN prodynorphin [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PDYNprovided by VGNC
Official Full Name: prodynorphinprovided by VGNC
Primary source: VGNC:VGNC:32723
See related: BGD:BT17558; Ensembl:ENSBTAG00000045520
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 13

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	13	NC_037340.1 (53127708..53148824)

Chromosome 13 - NC_037340.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The investigation of Dyn A 1-17 metabolism at the blood-brain barrier (BBB) is important since the metabolites exhibit unique biological functions compared to the parent compound.
Title: The permeation of dynorphin A 1-6 across the blood brain barrier and its effect on bovine brain microvessel endothelial cell monolayer permeability.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables opioid receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in sensory perception	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in axon terminus	IEA Inferred from Electronic Annotation more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: proenkephalin-B

Names: beta-neoendorphin-dynorphin; preprodynorphin; proenkephalin-B preproprotein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174139.3 → NP_776564.2 proenkephalin-B preproprotein

Status: VALIDATED

Source sequence(s)

NKLS02000013

UniProtKB/TrEMBL

A0A3Q1MCT6, E1BDY2

Related

ENSBTAP00000055430.1, ENSBTAT00000064586.2

Conserved Domains (1) summary

pfam01160
Location:21 → 67

Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

Range

53127708..53148824

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015474113.3 → XP_015329599.1 proenkephalin-B isoform X1

UniProtKB/TrEMBL

A0A3Q1MCT6, E1BDY2

Conserved Domains (1) summary

pfam01160
Location:21 → 67

Opiods_neuropep; Vertebrate endogenous opioids neuropeptide