OXTR oxytocin receptor [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: OXTRprovided by VGNC
Official Full Name: oxytocin receptorprovided by VGNC
Primary source: VGNC:VGNC:32516
See related: BGD:BT11640
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	22	NC_037349.1 (17776079..17832707)

Chromosome 22 - NC_037349.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Up-regulation of endometrial oxytocin receptor is associated with the timing of luteolysis in heifers with two and three follicular wavesdagger.
Title: Up-regulation of endometrial oxytocin receptor is associated with the timing of luteolysis in heifers with two and three follicular waves†.
relationship between luteal concentrations of oxytocin (OT), noradrenaline (NA), progesterone (P4), oxytocin receptors (OT-R) and beta(2)-adrenoreceptors (beta(2)-R) gene expression and their protein level throughout the estrous cycle
Title: Relationship between concentrations of progesterone, oxytocin, noradrenaline, gene expression and protein level for their receptors in corpus luteum during estrous cycle in the cow.
Oxytocin receptor down-regulation is not necessary for reducing oxytocin-induced prostaglandin F(2alpha) accumulation by interferon-tau in a bovine endometrial epithelial cell line.
Title: Oxytocin receptor down-regulation is not necessary for reducing oxytocin-induced prostaglandin F(2alpha) accumulation by interferon-tau in a bovine endometrial epithelial cell line.
study demonstrated that bovine lymphocytes express oxytocin receptors and that this expression can be regulated in a steroid-dependent manner
Title: Expression and regulation of functional oxytocin receptors in bovine T lymphocytes.
These data show that E2 can stimulate PGF2 alpha secretion by increasing OXTR expression in bovine endometrial cells in vitro, but only after exposure to P4.
Title: Prolonged progesterone treatment of endometrial epithelial cells modifies the effect of estradiol on their sensitivity to oxytocin.
the presence of oxytocin receptors (OTR) in oviductal tissues is evident in the follicular phase cow
Title: The concentrations of catecholamines and oxytocin receptors in the oviduct and its contractile activity in cows during the estrous cycle.
Components of the interferon system are found to significantly influence the transcription of the bovine oxytocin receptor gene.
Title: Transcriptional regulation of the bovine oxytocin receptor gene.

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General gene information

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Markers

PMC170950P1 (e-PCR)
- UniSTS:271619

OXTR (e-PCR), detects polymorphism
- UniSTS:278874

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables oxytocin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables peptide binding	IEA Inferred from Electronic Annotation more info	PubMed
enables vasopressin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in female pregnancy	IEA Inferred from Electronic Annotation more info	PubMed
involved_in maternal process involved in parturition	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of systemic arterial blood pressure by vasopressin	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: oxytocin receptor

Names: OT-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174134.2 → NP_776559.1 oxytocin receptor

See identical proteins and their annotated locations for NP_776559.1

Status: PROVISIONAL

Source sequence(s)

AF101724

UniProtKB/Swiss-Prot

P56449

Conserved Domains (2) summary

pfam00001
Location:56 → 331

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:46 → 146

7tm_4; Olfactory receptor